Aladdin™ NHS-Biotin - ≥99% , CAS No.35013-72-0

CAS: 35013-72-0 Cat. No.: A638743 Peso molecular: 341.38 Beilstein Registry Number: 4720781 Número EC: 609-055-0

GRADE & PURITY ≥99%

Synonyms

(+)-Biotin N-succinimidyl ester | D-Biotin N-Succinimidyl Ester | Biotin-NHS ester | Biotin N-Hydroxysuccinimide Ester | Biotin-NHS | (+)-Biotin N-hydroxysuccinimide ester | Biotin-Osu | (+)-Biotin-NHS ester | N-Succinimidyl D-biotinate | N-Hydroxysuccini

Storage

Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

Descripción general

Product introduction：

The N-hydroxysuccinimide ester (NHS)-biotin modification helps in the biotinylation of the target lysine residue at its ε-amino group and identifies the surface lysine residues. It is used as a tool to identify the interaction of proteins with several biological molecules, like protein-polysaccharide interactions, protein-protein interactions, protein-nucleic acid interactions, and protein-ligand interactions. NHS-biotin may be used in the biotinylation of proteins and peptides. It is typically coupled to primary amine in the pH range of 6.5-8.5.

Specifications

Sinónimos

(+)-Biotin N-succinimidyl ester | D-Biotin N-Succinimidyl Ester | Biotin-NHS ester | Biotin N-Hydroxysuccinimide Ester | Biotin-NHS | (+)-Biotin N-hydroxysuccinimide ester | Biotin-Osu | (+)-Biotin-NHS ester | N-Succinimidyl D-biotinate | N-Hydroxysuccini

Especificaciones y pureza

≥99%

Condiciones de almacenamiento de almacenamiento

Store at -20°C, Argon charged, Desiccated

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥99%

Nombres e identificadores

• Sonrisas canónicas: C1CC(=O)N(C1=O)OC(=O)CCCCC2C3C(CS2)NC(=O)N3
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate
• InChIKey: YMXHPSHLTSZXKH-RVBZMBCESA-N
• INCHI: 1S/C14H19N3O5S/c18-10-5-6-11(19)17(10)22-12(20)4-2-1-3-9-13-8(7-23-9)15-14(21)16-13/h8-9,13H,1-7H2,(H2,15,16,21)/t8-,9-,13-/m0/s1
• Isómeros SMILES: C1CC(=O)N(C1=O)OC(=O)CCCC[C@H]2[C@@H]3[C@H](CS2)NC(=O)N3
• WGK Alemania: 3
• Peso molecular: 341.38
• Beilstein: 4720781
• Reaxy-Rn: 4720780
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4720780&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Biotin and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Biotin and derivatives
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Biotin and derivatives
• Alternative Parents: Thienoimidazolidines Imidazolidinones Pyrrolidine-2-ones Dicarboximides Thiophenes Thiolanes Lactams Ureas Carboxylic acid salts Monocarboxylic acids and derivatives Azacyclic compounds Dialkylthioethers Organonitrogen compounds Organic salts Organic oxides Hydrocarbon derivatives Organopnictogen compounds Carbonyl compounds
• Molecular Framework: Aliphatic heteropolycyclic compounds
• Substituents: Biotin_derivative - Biotin - Thienoimidazolidine - Imidazolidinone - Pyrrolidone - 2-pyrrolidone - Dicarboximide - Imidazolidine - Pyrrolidine - Thiolane - Thiophene - Urea - Carboxylic acid salt - Lactam - Carbonic acid derivative - Thioether - Azacycle - Dialkylthioether - Carboxylic acid derivative - Monocarboxylic acid or derivatives - Organic salt - Organonitrogen compound - Organopnictogen compound - Organic nitrogen compound - Organooxygen compound - Carbonyl group - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Aliphatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as biotin and derivatives. These are organic compounds containing a ureido (tetrahydroimidizalone) ring fused with a tetrahydrothiophene ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMF(Dimethylformamide),DMSO(Dimethylsulfoxide)
• Sensibilidad: Moisture sensitive；air sensitive；heat sensitive
• Punto de fusión (°C): 140°C
• Peso molecular: 341.380 g/mol
• XLogP3: -0.200
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 341.105 Da
• Monoisotopic Mass: 341.105 Da
• Topological Polar Surface Area: 130.000 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 525.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 3
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

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9. Fengchun Zhao, Guanqun Wang, Xinrui Cao, Wenxu Song, Min Guo, Huimin Wang, Zhengyou Yang.  (2025)  Non-competitive immunoassay for zearalenone based on phage display developed recombinant antibody and anti-immunocomplex peptide.  FOOD CHEMISTRY,      [PMID:39848053] [10.1016/j.foodchem.2025.142943]

10. Huinan Chen, Jingyao Song, Yuanyuan Li, Dongmei Deng, Yuchen Song, Xiaoli Zhu, Liqiang Luo.  (2024)  Cascade signal amplifying strategy for ultrasensitive detection of tumor biomarker by DNAzyme cleaving mediated HCR.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2024.136466]

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