Aloin - 10mM in DMSO , CAS No.1415-73-2

CAS: 1415-73-2 Cat. No.: A408967 Fórmula: C₂₁H₂₂O₉ Peso molecular: 418.39 Beilstein Registry Number: 6077558 Número EC: 215-808-0

GRADE & PURITY 10mM in DMSO

Synonyms

Barbaloin, Barbalin | 9(10H)-Anthracenone, 10-β-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-, (10S)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Aloin Aloin (Barbaloin, Barbalin), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.
In vitro

Aloin, a natural anthracycline from Aloe vera, is a tyrosinase inhibitor with inhibitory rates of 2mM. Aloin shows a pronounced antiproliferative effect at physiological concentration (IC50 = 97 μM), causes cell cycle arrest in the S phase and markedly increases HeLaS3 cell apoptosis (to 24%). Aloin causes a reduction in the proportion of cells undergoing mitosis by induction of apoptosis, inhibition of topo II alpha protein expression and downregulation of cyclin B1 protein expression in MCF-7 cell line.

In vivo

Cell Data

cell lines：HF1A3, HF4.9 and HF28RA cells

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Sinónimos

Barbaloin, Barbalin | 9(10H)-Anthracenone, 10-β-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-, (10S)-

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Aloin (Barbaloin, Barbalin), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nombres e identificadores

Isómeros SMILES

C1=CC2=C(C(=C1)O)C(=O)C3=C([C@H]2[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)C=C(C=C3O)CO

WGK Alemania

3

RTECS

LZ6520000

Peso molecular

418.39

Beilstein

6077558

Reaxy-Rn

25113924

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25113924&ln=

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 177 mg/mL (199.94 mM); Water: 177 mg/mL (199.94 mM); Ethanol: 177 mg/mL (199.94 mM)
• Punto de fusión (°C): 148-149°C

Preguntas frecuentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1415-73-2, the molecular formula is C21H22O9, and the molecular weight is 418.39 g/mol.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.