Amcasertib (BBI503) - Moligand™, 10mM in DMSO , CAS No.1129403-56-0

CAS: 1129403-56-0 Cat. No.: A420669 Peso molecular: 539.69

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

1H-Pyrrole-3-carboxamide | N-​[2-​(diethylamino)​ethyl]​-​5-​[[1,​2-​dihydro-​2-​oxo-​5-​(2-​phenyl-​4-​thiazolyl)​-​3H-​indol-​3-​ylidene]​methyl]​-​2,​4-​dimethyl-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Amcasertib (BBI503) Amcasertib (BBI503), a first-in-class cancer stemness kinase inhibitor, is claimed to inhibit Nanog and other CSC pathways by targeting kinases with potential anticancer activity.

Targets

Nanog

In vitro

BBI-503 is orally-administered compound, which is designed to target CSC pathways in multiple tumour types.

In vivo

BBI503 inhibits Nanog and other cancer stem cell pathways by targeting kinases, and shows encouraging early signs of anti-cancer activity for patients with advanced colorectal cancer.

Specifications

Sinónimos

1H-Pyrrole-3-carboxamide | N-​[2-​(diethylamino)​ethyl]​-​5-​[[1, ​2-​dihydro-​2-​oxo-​5-​(2-​phenyl-​4-​thiazolyl)​-​3H-​indol-​3-​ylidene]​methyl]​-​2, ​4-​dimethyl-

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Amcasertib (BBI503), a first-in-class cancer stemness kinase inhibitor, is claimed to inhibit Nanog and other CSC pathways by targeting kinases with potential anticancer activity.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Propiedades del producto

• ALogP: 5.119
• hba_count: 3
• Recuento HBD: 3
• Enlace rotable: 9

Nombres e identificadores

• Sonrisas canónicas: CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)C4=CSC(=N4)C5=CC=CC=C5)NC2=O)C
• IUPAC Name: N-[2-(diethylamino)ethyl]-2,4-dimethyl-5-[[2-oxo-5-(2-phenyl-1,3-thiazol-4-yl)-1H-indol-3-ylidene]methyl]-1H-pyrrole-3-carboxamide
• InChIKey: QDWKGEFGLQMDAM-UHFFFAOYSA-N
• INCHI: 1S/C31H33N5O2S/c1-5-36(6-2)15-14-32-30(38)28-19(3)26(33-20(28)4)17-24-23-16-22(12-13-25(23)34-29(24)37)27-18-39-31(35-27)21-10-8-7-9-11-21/h7-13,16-18,33H,5-6,14-15H2,1-4H3,(H,32,38)(H,34,37)
• Isómeros SMILES: CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)C4=CSC(=N4)C5=CC=CC=C5)NC2=O)C
• Peso molecular: 539.69
• Reaxy-Rn: 18996620
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18996620&ln=

Propiedades químicas y físicas

• DMSO (mg/ml) Solubilidad máxima: 14
• DMSO (mM) Solubilidad máxima: 25.94081788
• Agua (mg/ml) Solubilidad máxima: ＜1