Amfebutamone (Bupropion) HCl - 10mM in DMSO , Norepinephrine transporter inhibitor, CAS No.31677-93-7, Norepinephrine transporter inhibitor

CAS: 31677-93-7 Cat. No.: A409254 Peso molecular: 276.2 Número EC: 250-759-9

GRADE & PURITY 10mM in DMSO

Synonyms

1-​(3-​chlorophenyl)​-​2-​[(1,​1-​dimethylethyl)​amino]​-1-​propanone,hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Amfebutamone (Bupropion) HCl is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

1-​(3-​chlorophenyl)​-​2-​[(1, ​1-​dimethylethyl)​amino]​-1-​propanone, hydrochloride (1:1)

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Amfebutamone (Bupropion) HCl is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Mecanismo de acción

Norepinephrine transporter inhibitor

Nombres e identificadores

• Isómeros SMILES: CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C.Cl
• CAS alternativo: 34911-55-2
• Peso molecular: 276.2
• Reaxy-Rn: 6161273
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6161273&ln=

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 36 mg/mL (200.36 mM); Water: 36 mg/mL (200.36 mM); Ethanol: 21 mg/mL (116.88 mM)
• Punto de fusión (°C): 233-234°C

Referencias

1. Qiaoyuan Cheng, Linjun Shou, Cen Chen, Shi Shi, Minghao Zhou.  (2017)  Application of ultra-high-performance liquid chromatography coupled with LTQ-Orbitrap mass spectrometry for identification, confirmation and quantitation of illegal adulterated weight-loss drugs in plant dietary supplements.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,      [PMID:28917128] [10.1016/j.jchromb.2017.09.009]

2. Sun Zhi, Wang Fangfang, Li Wenxuan, Ren Ruobing, Zhou Peipei, Jia Qingquan, Zhao Lingguo, Chen Di, Zuo Lihua.  (2024)  Pipette-tip solid-phase extraction coupled with matrix-assisted laser desorption/ionization mass spectrometry enables rapid and high-throughput analysis of antidepressants in rat serum.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,      [PMID:38997460] [10.1007/s00216-024-05439-x]