AMG-548 dihydrochloride - ≥99% , CAS No.A659023

CAS: A659023 Cat. No.: A659023 Peso molecular: 534.48

GRADE & PURITY ≥99%

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Descripción general

AMG-548 dihydrochloride, an orally active and selective p38α inhibitor ( K i =0.5 nM), shows slightly selective over p38β ( K i =36 nM) and >1000 fold selective against p38γ and p38δ . AMG-548 dihydrochloride is also extremely potent in the inhibition of

Appearance:Solid

IC50& Target:p38α|0.5 nM (Ki)|p38β|3.6 nM (Ki)|p38δ|2600 nM (Ki)|p38γ|4100 nM (Ki)|dog p38α|5.0 nM (Ki)|JNK 1|11480 nM (Ki)|JNK 2|39 nM (Ki)|JNK 3|61 nM (Ki)|CK1

In Vitro:AMG-548 dihydrochloride shows >1000 fold selective against p38γ (K i =2600 nM) and p38δ (k i =4100 nM). AMG-548 dihydrochloride has an modest selectivity against JNK2 (k i =39 nM) and JNK3 (k i =61 nM). AMG-548 dihydrochloride is also extremely potent in

In Vivo:AMG-548 dihydrochloride has rat F of 62% and dog F of 47%. The t 1/2 is 4.6 hours in rats and 7.3 hours in dogs. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Biological Activity:AMG-548 dihydrochloride, an orally active and selective p38α inhibitor ( K i =0.5 nM), shows slightly selective over p38β ( K i =36 nM) and >1000 fold selective against p38γ and p38δ . AMG-548 dihydrochloride is also extremely potent in the inhibition of

Specifications

Especificaciones y pureza

≥99%

Condiciones de almacenamiento de almacenamiento

Store at -20°C, Desiccated

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥99%

Nombres e identificadores

• Sonrisas canónicas: O=C1N(C)C(NCC(N)CC2=CC=CC=C2)=NC(C3=CC=NC=C3)=C1C4=CC=C5C=CC=CC5=C4.Cl.Cl
• Peso molecular: 534.48

Propiedades químicas y físicas

• Solubilidad: DMSO : 10 mg/mL (18.71 mM; ultrasonic and warming and heat to 60°C)