Aminophylline - 10mM in DMSO , Adenosine receptor antagonist, CAS No.317-34-0, Adenosine receptor antagonist

CAS: 317-34-0 Cat. No.: A408079 Peso molecular: 420.43 Número EC: 206-264-5

GRADE & PURITY 10mM in DMSO

Synonyms

Phyllocontin | 3,​9-​dihydro-​1,​3-​dimethyl-1H-​purine-​2,​6-​dione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Aminophylline Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.
In vitro

In vivo

Cell Data

cell lines：UMSCC10B, UMSCC14B, UMSCC17B, UMSCC22B, and UMSCC35, UMSCC38 cell lines

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

Phyllocontin | 3, ​9-​dihydro-​1, ​3-​dimethyl-1H-​purine-​2, ​6-​dione

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Mecanismo de acción

Adenosine receptor antagonist

Nombres e identificadores

• Isómeros SMILES: CN1C2=C(C(=O)N(C1=O)C)NC=N2.CN1C2=C(C(=O)N(C1=O)C)NC=N2.C(CN)N
• WGK Alemania: 3
• RTECS: XH5600000
• Número ONU: 2811
• Peso molecular: 420.43
• Reaxy-Rn: 5784418
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5784418&ln=

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 100 mg/mL Water: Insoluble; Ethanol: 100 mg/mL
• Punto de fusión (°C): 269-270°C

Referencias

1. Chaozhi Ma, Liyuan Zou, Yu Xia, Yijun Tu, Daquan Xue, Yanfang Yang, Dan Liu, Yanwen Liu, Hezhen Wu, Hanxiong Dan, Pengtao You.  (2018)  Extracts of Coleus forskohlii relieves cough and asthma symptoms via modulating inflammation and the extracellular matrix.  JOURNAL OF CELLULAR BIOCHEMISTRY,  120  (6): (9648-9655).  [PMID:30520122] [10.1002/jcb.28243]

2. Xingxing Duan, Bufan Yu, Guangrong Jin, Dengliang Zhang, Jiangshan Chen, Dongge Ma.  (2024)  Modification of mixed-halide quasi-2D perovskites by aminophylline towards efficient and spectrally stable blue light-emitting diodes with low efficiency roll-off.  Journal of Materials Chemistry C,      [PMID:] [10.1039/D4TC04214J]