Amisulpride - Moligand™, 10mM in DMSO , Dopamine receptors; D2 & D3 antagonist, CAS No.71675-85-9, Dopamine receptors; D2 & D3 antagonist

CAS: 71675-85-9 Cat. No.: A408070 Peso molecular: 369.48 Número EC: 275-831-7

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

DAN-2163 | 4-amino-N-((1-ethylpyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Amisulpride (DAN-2163) is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

DAN-2163 | 4-amino-N-((1-ethylpyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Amisulpride (DAN-2163) is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

ANTAGONIST

Mecanismo de acción

Dopamine receptors; D2 & D3 antagonist

Propiedades del producto

• ALogP: 1.5

Nombres e identificadores

• Isómeros SMILES: CCN1CCCC1CNC(=O)C2=CC(=C(C=C2OC)N)S(=O)(=O)CC
• WGK Alemania: 3
• RTECS: CV2308701
• Peso molecular: 369.48
• Reaxy-Rn: 6876191
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6876191&ln=

Objetivos asociados (humanos)

DRD2 Tclin D(2) dopamine receptor (3 Activities)

Discover Target: DRD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD3 Tclin D(3) dopamine receptor (2 Activities)

Discover Target: DRD3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR7 Tclin 5-hydroxytryptamine receptor 7 (1 Activities)

Discover Target: HTR7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro Water: 36 mg/mL (200.84 mM); DMSO: Insoluble; Ethanol: Insoluble
• Punto de fusión (°C): 127 °C

Referencias

1. Huanhuan Yang, Cong Liu, Chuanhong Zhu, Yan Zheng, Juan Li, Qianyun Zhu, Hao Wang, Xiangming Fang, Quan Liu, Man Liang, Zilong Liu.  (2023)  Determination of ten antipsychotics in blood, hair and nails: Validation of a LC–MS/MS method and forensic application of keratinized matrix analysis.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:37406464] [10.1016/j.jpba.2023.115557]

2. Junlei He, Jiahao Yuan, Juan Du, Xiaoguang Chen, Xinguo Zhang, Ande Ma, Jialiang Pan.  (2018)  Automated on-line SPE determination of amisulpride in human plasma using LC coupled with restricted-access media column.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2018.10.029]

3. Wen-Peng Zhang, Dong-Ying Chen.  (2017)  Crystal structures and physicochemical properties of amisulpride polymorphs.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:28371719] [10.1016/j.jpba.2017.03.030]