GRADE & PURITY Moligand™, ≥99%

Synonyms

APDC | PDC | PDTC | 1-Pyrrolidinecarbodithioic acid, ammonuim salt | AC2534 | AKOS000121506 | apdc | MFCD00012720 | NCGC00261718-01 | SCHEMBL463334 | Q-200528 | Ammonium pyrrolidine-1-carbodithioate | BCP24770 | HMS3675D15 | CCG-222337 | HMS3266N09 | P 87

Storage

Store at 2-8°C,Protected from light,Argon charged

Shipped In

Wet ice

Descripción general

Ammonium pyrrolidinedithiocarbamate is a nuclear factor κB (NF-κB) inhibitor.It functions as a chelating agent, which allows the preconcentration of trace metals from solution.Pyrrolidinedithiocarbamate (PDTC) has antioxidant properties. It inhibits apoptosis in lymphocytes, neurons and vascular endothelial cells

Specifications

Sinónimos

APDC | PDC | PDTC | 1-Pyrrolidinecarbodithioic acid, ammonuim salt | AC2534 | AKOS000121506 | apdc | MFCD00012720 | NCGC00261718-01 | SCHEMBL463334 | Q-200528 | Ammonium pyrrolidine-1-carbodithioate | BCP24770 | HMS3675D15 | CCG-222337 | HMS3266N09 | P 87

Especificaciones y pureza

Moligand™, ≥99%

Mecanismos bioquímicos y fisiológicos

Pyrrolidinedithiocarbamic acid (PDTC) ammonium salt is a potent inhibitor of NF κB (Nuclear Factor κB). Experiments show that micromolar amounts of this compound suppress IL-1β and completely inhibit the increase of nitric oxide synthase mRNA in response

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C, Protected from light, Argon charged

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥99%

Nombres e identificadores

• Sonrisas canónicas: C1CCN(C1)C(=S)[S-].[NH4+]
• IUPAC Name: azanium;pyrrolidine-1-carbodithioate
• InChIKey: MDDIUTVUBYEEEM-UHFFFAOYSA-N
• INCHI: 1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3
• Isómeros SMILES: C1CCN(C1)C(=S)[S-].[NH4+]
• WGK Alemania: 3
• Peso molecular: 164.29
• Beilstein: 3730472
• Reaxy-Rn: 10782484
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10782484&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Pyrrolidines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Pyrrolidines
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyrrolidines
• Alternative Parents: Azacyclic compounds Organosulfur compounds Organopnictogen compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Pyrrolidine - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organosulfur compound - Organonitrogen compound - Aliphatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as pyrrolidines. These are compounds containing a pyrrolidine ring, which is a five-membered saturated aliphatic heterocycle with one nitrogen atom and four carbon atoms.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: Soluble in water (50 mg/ml), ethanol, chloroform, and DMSO (100 mM).
• Sensibilidad: Air sensitive，Heat sensitive，Hygroscopic，Light sensitive
• Punto de fusión (°C): 149-152°C
• Peso molecular: 164.300 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 164.044 Da
• Monoisotopic Mass: 164.044 Da
• Topological Polar Surface Area: 37.300 Ų
• Heavy Atom Count: 9
• Formal Charge: 0
• Complexity: 91.100
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Referencias

1. Yujing He, Jing Hu, Wei Zou, Hanjiao Chen, Xiaoming Jiang, Xiandeng Hou.  (2023)  Chemical vapor generation of tungsten for atomic spectrometric determination: Homogeneous sensitizer and mechanism study.  ANALYTICA CHIMICA ACTA,      [PMID:37709475] [10.1016/j.aca.2023.341746]

2. Shi Sun, Yifang Wang, Jinhu Li, Ailing Wu, Yan Xie, Zhao Wang, Xinjie Zhao, Dandan Wang, Xiaolong Wu, Xinguang Liu.  (2023)  Network Pharmacology-Based Approach to Investigate the Active Ingredients and Therapeutic Mechanisms of Jingu Tongxiao Pill against Osteoarthritis.  ACS Omega,      [PMID:37663478] [10.1021/acsomega.3c04724]

3. Jiancheng Zhang, Congcong Zhang, Yuyang Li, Jingjing Xiao, Yilun Zhang, Min Jia, Lixia Lu, Hongyan Zhang, Jun Zhou, Zhenguo Zhang, Xin Du.  (2023)  An electrochemical sensing platform for biomonitoring the potential toxicity of plastic particles by detecting NO.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.144797]

4. Haotian Zhang, Ziyun Wei, Yichen Tong, Xiuping Song, Siyue Li, Yuanfang Sun, Chun Liu, Fei Han, Jia Yu.  (2023)  Spectrum-effect relationship study to reveal the pharmacodynamic substances in Flos Puerariae-Semen Hoveniae medicine pair for the treatment of alcohol-induced liver damage.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:37196817] [10.1016/j.jep.2023.116628]

5. Yafei Zhen, Tao Lin, Hanjiao Chen, Jing Hu, Xiandeng Hou.  (2022)  Vapor Generation of Rare-Earth Elements via Reaction with Tetrahydroborate: Chemical Identities and Mechanisms of Formation.  ANALYTICAL CHEMISTRY,      [PMID:36301518] [10.1021/acs.analchem.2c01486]

6. Chao Li, Linna Duan, Mingchao Han, Hongwei He, Mengxiang Yuan, Hairong Wang.  (2022)  A Chelating Resin of EDTA-Type Modified Cross-Linking Polystyrene to Preconcentrate Trace Metals for Seawater Detection.  Journal of Analytical Methods in Chemistry,      [PMID:36275429] [10.1155/2022/2080600]

7. Wenjun Jiang, Xiaoying Wang, Siwei Su, Sen Du, Hongqiang Song.  (2022)  Identifying the shared genes and KEGG pathways of Resolvin D1-targeted network and osteoarthritis using bioinformatics.  Bioengineered,      [PMID:35436417] [10.1080/21655979.2022.2061288]

8. Haoyue Xue, Liyan Jia, Haijuan Jiang, Shu Qin, Yukun Yang, Junxue Wu, Xu Jing.  (2022)  A successive homogeneous liquid-liquid microextraction based on solidification of switchable hydrophilicity solvents and ionic liquids for the detection of pyrethroids and cadmium in drinks.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,      [PMID:] [10.1016/j.jfca.2022.104569]

9. Caizhen Liang, Xiaobao Xie, Dandan Zhang, Jin Feng, Shunying Lu, Qingshan Shi.  (2021)  Biomass carbon dots derived from Wedelia trilobata for the direct detection of glutathione and their imaging application in living cells.  Journal of Materials Chemistry B,  9  (28): (5670-5681).  [PMID:34195715] [10.1039/D0TB02979C]

10. Jingli Zhang, Lingling Zhu, Hong Shi, Huizhe Zheng.  (2021)  Protective effects of miR‑155‑5p silencing on IFN‑γ‑induced apoptosis and inflammation in salivary gland epithelial cells.  Experimental and Therapeutic Medicine,  22  (2): (1-11).  [PMID:34194560] [10.3892/etm.2021.10314]

11. Jia Qinghui, Zhang Haihua, Su Yongmei, Liu Xin, Bai Jiangsong, Lang Wuying, Shi Qiumei, Feng Minshan.  (2021)  Strictosamide alleviates the inflammation in an acute ulcerative colitis (UC) model.  JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY,  77  (2): (283-294).  [PMID:33595775] [10.1007/s13105-021-00796-y]

12. Wang Wanyue, Li Xin, Xu Ye, Guo Weikang, Yu Hui, Zhang Lu, Wang Yaoxian, Chen Xiuwei.  (2021)  Acetylation-stabilized chloride intracellular channel 1 exerts a tumor-promoting effect on cervical cancer cells by activating NF-κB.  CELLULAR ONCOLOGY,  44  (3): (557-568).  [PMID:33469837] [10.1007/s13402-020-00582-w]

13. Changrong Wang, Xiaoguang Shi, Huijuan Song, Chuangnian Zhang, Xiaoli Wang, Pingsheng Huang, Anjie Dong, Yumin Zhang, Deling Kong, Weiwei Wang.  (2020)  Polymer-lipid hybrid nanovesicle-enabled combination of immunogenic chemotherapy and RNAi-mediated PD-L1 knockdown elicits antitumor immunity against melanoma.  BIOMATERIALS,      [PMID:33278683] [10.1016/j.biomaterials.2020.120579]

14. Shiwei Yang, Yihuan Song, Qingfang Ma, Heyong Cheng, Yuanchao Wang, Jinhua Liu.  (2020)  Quantification of ultra-trace organolead species in environmental water by inductively coupled plasma mass spectrometry with online solid-phase extraction and high performance liquid chromatographic separation.  ANALYTICA CHIMICA ACTA,      [PMID:32993871] [10.1016/j.aca.2020.07.046]

15. Wei Zou, Chenghui Li, Jing Hu, Xiandeng Hou.  (2020)  Selective determination of Cr(Ⅵ) and non-chromatographic speciation analysis of inorganic chromium by chemical vapor generation-inductively coupled plasma mass spectrometry.  TALANTA,      [PMID:32797885] [10.1016/j.talanta.2020.121128]

16. Yuxi Lu, Xuelu Gao, Chen-Tung Arthur Chen.  (2019)  Separation and determination of colloidal trace metals in seawater by cross-flow ultrafiltration, liquid-liquid extraction and ICP-MS.  MARINE CHEMISTRY,      [PMID:] [10.1016/j.marchem.2019.103685]

17. Jinrong Lu, Xiaonan Wu, Yao Li, Wenquan Cui, Yinghua Liang.  (2018)  Modified silica gel surface with chelating ligand for effective mercury ions adsorption.  Surfaces and Interfaces,      [PMID:] [10.1016/j.surfin.2018.04.005]

18. Linlin Lu, Chongchong Feng, Jie Xu, Fengyang Wang, Haijun Yu, Zhiai Xu, Wen Zhang.  (2017)  Hydrophobic-carbon-dot-based dual-emission micelle for ratiometric fluorescence biosensing and imaging of Cu2+ in liver cells.  BIOSENSORS & BIOELECTRONICS,      [PMID:28193561] [10.1016/j.bios.2017.01.066]

19. Xiaojun Wang, Guoliang Xu, Peng Chen, Xueying Liu, Ye Fang, Siyu Yang, Guozhen Wang.  (2016)  Arsenic speciation analysis in environmental water, sediment and soil samples by magnetic ionic liquid-based air-assisted liquid–liquid microextraction.  RSC Advances,  6  (111): (110247-110254).  [PMID:] [10.1039/C6RA21199B]

20. Xiaojun Wang, Long Wu, Jiaqi Cao, Xincheng Hong, Rui Ye, Weiji Chen, Ting Yuan.  (2016)  Magnetic effervescent tablet-assisted ionic liquid dispersive liquid–liquid microextraction of selenium for speciation in foods and beverages.  Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment,      [PMID:27181611] [10.1080/19440049.2016.1189807]

21. Zhiyuan Dai, Yang Yang, Zhiyu Fang, Lei Li, Xiongkai Tang, Shuyuan Wan, Lingfeng Chao, Zhe Liu, Ruihao Chen, Hongqiang Wang.  (2026)  Bifacial carbodithioate-lead chelating for efficient and robust inverted perovskite solar cells.  Science Advances,  12  (1):   [PMID:41477860] [10.1126/sciadv.adz2113]

22. Siyan Cao, Runzhi Cai, Shuhua Xi, Yue Wang.  (2026)  Subchronic arsenic exposure induced intestinal microbiota dysbiosis and intestinal inflammation via activating the NF-κB signaling pathway.  FOOD AND CHEMICAL TOXICOLOGY,      [PMID:41653980] [10.1016/j.fct.2026.115991]