Anastrozole (ZD-1033) - Moligand™, 10mM in DMSO , Cytochrome P450 19A1 inhibitor, CAS No.120511-73-1, Cytochrome P450 19A1 inhibitor

CAS: 120511-73-1 Cat. No.: A409166 Peso molecular: 293.37 Número EC: 601-715-6

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

α1,​α1,​α3,​α3-​tetramethyl-​5-​(1H-​1,​2,​4-​triazol-​1-​ylmethyl)​- 1,​3-​benzenediacetonitril​e

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Anastrozole (ZD-1033) Anastrozole (ZD-1033) is a third-generation nonsteroidal selective aromatase inhibitor. It may offer greater selectivity compared with other aromatase inhibitors, being without any intrinsic endocrine effects and with no apparent e
In vitro

Anastrozole has high intrinsic potency in vitro and inhibits human placental aromatase with an IC50 of 15 nM. Anastrozole it is 200 times as potent as AG, twice as potent as 4-OHA and one third as potent as fadrozole. . Anastrozole inhibits aromatase by binding competitively to the hem group of the CYP unit of the enzyme thereby reducing estrogen biosynthesis in the periphery and the breast. Anastrozole has little or no effect on other steroid hormones.

In vivo

Anastrozole (0.1 mg/kg) given orally to mature rats on Day 2 or 3 of the estrous cycle, blocked ovulation in mature females; in pubertal rats, the same dose given for 3 days completely blocks androstenedione-stimulated uterine development. These effects may be attributes to inhibition of the normal preovulatory rise in ovarian follicular estrogen synthesis in mature females and to inhibition of metabolism of the exogenous androstenedione by the immature ovary in prepubertal females. Twice-daily administration of >9.1 mg/kg of Anastrozole given orally to male pigtailed monkeys inhibits peripheral aromatase, thereby reducing circulating estradiol concentrations by 50% to 60%.
Cell Data

cell lines：Neurons

Concentrations：

Incubation Time：

Powder Purity:≥97%

Specifications

Sinónimos

α1, ​α1, ​α3, ​α3-​tetramethyl-​5-​(1H-​1, ​2, ​4-​triazol-​1-​ylmethyl)​- 1, ​3-​benzenediacetonitril​e

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Anastrozole (ZD-1033) is a third-generation nonsteroidal selective aromatase inhibitor. It may offer greater selectivity compared with other aromatase inhibitors, being without any intrinsic endocrine effects and with no apparent effect on the synthesis o

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Cytochrome P450 19A1 inhibitor

Propiedades del producto

• ALogP: 2.1

Nombres e identificadores

• Isómeros SMILES: CC(C)(C#N)C1=CC(=CC(=C1)CN2C=NC=N2)C(C)(C)C#N
• WGK Alemania: 3
• RTECS: CZ1465000
• Peso molecular: 293.37
• Reaxy-Rn: 8005958
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8005958&ln=

Objetivos asociados (humanos)

CYP19A1 Tclin Aromatase (12 Activities)

Discover Target: CYP19A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Referencias

1. Luo Yu-Wei, Zhou Jiang-Peng, Ji Hongyu, Xu Doudou, Zheng Anqi, Wang Xin, Dai Zhizheng, Luo Zhicheng, Cao Fang, Wang Xing-Yue, Bai Yunfang, Chen Di, Chen Yueming, Wang Qi, Yang Yaying, Zhang Xinghai, Chiu Sandra, Peng Xiaozhong, Huang Ai-Long, Tang Kai-Fu.  (2024)  SARS-CoV-2 N protein-induced Dicer, XPO5, SRSF3, and hnRNPA3 downregulation causes pneumonia.  Nature Communications,  15  (1): (1-23).  [PMID:39138195] [10.1038/s41467-024-51192-1]

2. Tiantian Fu, Bingyi Yao, Yuanqing Guo, Yujia Yang, Junze Huang, Chenmeizi Liang, Yuanjin Zhang, Xin Wang.  (2025)  Metabolism of nifedipine by placental CYP19A1 and competitive inhibition by chlorpromazine.  BIOCHEMICAL PHARMACOLOGY,      [PMID:41110490] [10.1016/j.bcp.2025.117425]

3. Le-hao Jin, Zhe-yan Zhang, Xiao-yu Xu, Zhong-xi Chen, Jing Chen, Yu-bin Lan, Liu-liu Pan, Xiao-dan Zhang.  (2026)  The Inhibitory Effect of Anastrozole on the Metabolism of Abemaciclib In Vitro and In Vivo.  ACS Omega,      [PMID:] [10.1021/acsomega.6c00144]