Angiotensinogen from Human Plasma, CAS No.11002-13-4

CAS: 11002-13-4 Cat. No.: np001156 Peso molecular: 1645.9 PubChem CID: 131698192

GRADE & PURITY BioReagent, Native, PBS Only, ≥95%(SDS-PAGE), Pre-lyophilization Protein Concentration

Accession #

P01019

Descripción general

Angiotensinogen (AGT) is a glycoprotein found in plasma at a concentration of 2.8-7.1 mg per 100mL in healthy individuals. AGT is produced primarily by the liver but also is synthesized in the brain, large arteries, kidneys and adipose tissue. In plasma it exists as a monomeric form (55-65 kDa) as well as a high molecular mass form (200-550 kDa). In non-pregnant individuals with normal blood pressure, the high molecular mass form accounts for 3% of total circulating AGT. In the first half of pregnancy the total AGT increases by 4-fold and the high molecular mass form increases by 20-fold. Up to 80% of the total AGT in amniotic fluid is the high molecular mass form.
Angiotensinogen is an essential component of the renin-angiotensin system, a potent regulator of blood pressure, body fluid and electrolyte homeostasis. It functions as the substrate for human renin and is the precursor molecule for Angiotensins 1,2,3,4, 1-9, 1-7, 1-5 and 1-4. AGT is also a member of the SERPIN family but it is not known to possess protease-inhibitory activity. Levels in plasma are increased by plasma corticosteroid, estrogen, thyroid hormone and angiotensin-2 levels.
Extinction Coefficient: 0.92
Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

Specifications

Product Name

Angiotensinogen from Human Plasma, CAS No.11002-13-4

Sinónimos

Hypertensinogen, Renin substrate | AGT | ANHU | hFLT1 | SERPINA8

Grado

BioReagent, Native, PBS Only

Especificaciones y pureza

BioReagent, Native, PBS Only, ≥95%(SDS-PAGE), Pre-lyophilization Protein Concentration

Mecanismos bioquímicos y fisiológicos

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Angiotensin-2: Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and

Número de adhesión

P01019

Peso molecular previsto

55-65 kDa

CAS

11002-13-4

Tipo de molécula

Protein

Almacenamiento y envío

Forma

Lyophilized from 30 mM sodium phosphate, pH 6.8

Concentración

Pre-lyophilization Protein Concentration

Reconstitución

After centrifugation, we suggest addition of de-ionized H2O to the original volume (See COA), followed by gentle mixingto ensure adequate homogenization. If further dilution is required, please use the lyophilization buffer.

Condiciones de almacenamiento de almacenamiento

Store at -20°C,Avoid repeated freezing and thawing

Enviado en

Ice chest + Ice pads

Estabilidad y almacenamiento

Store at -20℃ long term (>1 year). Upon reconstitution, it is recommended to aliquot. Avoid freeze/thaw cycle.