Antalarmin hydrochloride - ≥99% , CAS No.220953-69-5

CAS: 220953-69-5 Cat. No.: A286834 Peso molecular: 415.01

GRADE & PURITY ≥99%

Synonyms

DTXSID00582018 | E98747 | Antalarmin hydrochloride, >=98% (HPLC), solid | HY-103377 | Butyl-ethyl-[2,5,6-trimethyl-7-(2,4,6-trimethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-amine hydrochloride | N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-

Storage

Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

Descripción general

Application：

Antalarmin hydrochloride has been used:

to study its effect on stress-induced tryptophan hydroxylase 2 activity

to study the anxiogenic effects of corticotropin-releasing factor 1 (CRF1) activation

to analyze the therapeutic effect of blocking corticotrophin-releasing hormone (CRH) signaling in treating social stress-induced depression

Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.

Specifications

Sinónimos

DTXSID00582018 | E98747 | Antalarmin hydrochloride, >=98% (HPLC), solid | HY-103377 | Butyl-ethyl-[2, 5, 6-trimethyl-7-(2, 4, 6-trimethyl-phenyl)-7H-pyrrolo[2, 3-d]pyrimidin-4-yl]-amine hydrochloride | N-Butyl-N-ethyl-2, 5, 6-trimethyl-7-(2, 4, 6-trimethylphenyl)-

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

Non-peptide corticotropin-releasing hormone receptor 1 (CRF1) antagonist (Ki= 1 nM). Suppresses CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety.Antalarmin serves as a non steroidal inhibitor of

Condiciones de almacenamiento de almacenamiento

Store at -20°C, Argon charged, Desiccated

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

ANTAGONIST

Pureza

≥99%

Nombres e identificadores

• Pubchem Sid: 504768031
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504768031
• Sonrisas canónicas: CCCCN(CC)C1=NC(=NC2=C1C(=C(N2C3=C(C=C(C=C3C)C)C)C)C)C.Cl
• IUPAC Name: N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine;hydrochloride
• InChIKey: CGDGXEDXEXACKQ-UHFFFAOYSA-N
• INCHI: 1S/C24H34N4.ClH/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5;/h13-14H,9-12H2,1-8H3;1H
• Isómeros SMILES: CCCCN(CC)C1=NC(=NC2=C1C(=C(N2C3=C(C=C(C=C3C)C)C)C)C)C.Cl
• Peso molecular: 415.01
• Reaxy-Rn: 8299718
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8299718&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Pyrroles
      • Subclass Substituted pyrroles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Pyrroles
• Subclass: Substituted pyrroles
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpyrroles
• Alternative Parents: Pyrrolo[2,3-d]pyrimidines Dialkylarylamines Aminopyrimidines and derivatives Imidolactams Benzene and substituted derivatives Heteroaromatic compounds Azacyclic compounds Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 1-phenylpyrrole - Pyrrolo[2,3-d]pyrimidine - Pyrrolopyrimidine - Dialkylarylamine - Aminopyrimidine - Monocyclic benzene moiety - Pyrimidine - Imidolactam - Benzenoid - Heteroaromatic compound - Azacycle - Amine - Organonitrogen compound - Hydrocarbon derivative - Organic nitrogen compound - Hydrochloride - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as phenylpyrroles. These are polycyclic aromatic compounds containing a benzene ring linked to a pyrrole ring through a CC or CN bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: Solvent:DMSO, Max Conc. mg/mL: 41.5, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 41.5, Max Conc. mM: 100
• Sensibilidad: Moisture sensitive
• Peso molecular: 415.000 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 414.255 Da
• Monoisotopic Mass: 414.255 Da
• Topological Polar Surface Area: 34.000 Ų
• Heavy Atom Count: 29
• Formal Charge: 0
• Complexity: 485.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

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