≥95%, ~5mM in dimethyl formamide for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 10 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
APF is a fluorescent reagent (λ|Ex|max|: 490nm; λ|Em|max|: 515nm) used in the detection of highly reactive oxygen species (hROS). Immediately reacts with hROS such as hydroxyl radical, peroxynitrite and hypochlorite, and the fluorescence intensity greatly increases. When using APF together with HPF, it also allows for specific detection of hypochlorite (|-|OCl) to elucidate reliable roles of|-|OCl in biological systems such as netrophils. Peroxynitrite can also be detected in distinction from nitric oxide and superoxide since APF does not react with nitric oxide, superoxide and hydrogen peroxide. APF is resistant to light-induced autooxidation
| Rangos de excitación y emisión | λex 490 nm, λem 515 nm |
|---|
| Sonrisas canónicas | C1=CC=C(C(=C1)C2=C3C=CC(=O)C=C3OC4=C2C=CC(=C4)OC5=CC=C(C=C5)N)C(=O)O |
|---|---|
| IUPAC Name | 2-[3-(4-aminophenoxy)-6-oxoxanthen-9-yl]benzoic acid |
| InChIKey | GIERQYKZWFLVGR-UHFFFAOYSA-N |
| INCHI | 1S/C26H17NO5/c27-15-5-8-17(9-6-15)31-18-10-12-22-24(14-18)32-23-13-16(28)7-11-21(23)25(22)19-3-1-2-4-20(19)26(29)30/h1-14H,27H2,(H,29,30) |
| Isómeros SMILES | C1=CC=C(C(=C1)C2=C3C=CC(=O)C=C3OC4=C2C=CC(=C4)OC5=CC=C(C=C5)N)C(=O)O |
| Peso molecular | 423.42 |
| Reaxy-Rn | 29522143 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29522143&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Clase | Benzopyrans |
| Subclass | 1-benzopyrans |
| Intermediate Tree Nodes | Dibenzopyrans |
| Direct Parent | Xanthenes |
| Alternative Parents | Diarylethers Benzoic acids Phenoxy compounds Phenol ethers Aniline and substituted anilines Benzoyl derivatives Primary aromatic amines Heteroaromatic compounds Amino acids Cyclic ketones Oxacyclic compounds Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Xanthene - Diaryl ether - Benzoic acid or derivatives - Benzoic acid - Phenoxy compound - Benzoyl - Aniline or substituted anilines - Phenol ether - Monocyclic benzene moiety - Benzenoid - Primary aromatic amine - Heteroaromatic compound - Amino acid or derivatives - Amino acid - Cyclic ketone - Carboxylic acid derivative - Carboxylic acid - Oxacycle - Ether - Monocarboxylic acid or derivatives - Organic nitrogen compound - Amine - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organopnictogen compound - Organonitrogen compound - Organooxygen compound - Primary amine - Aromatic heteropolycyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as xanthenes. These are polycyclic aromatic compounds containing a xanthene moiety, which consists of two benzene rings joined to each other by a pyran ring. |
| External Descriptors | Not available |
| Solubilidad | Insoluble in water. |
|---|---|
| Índice de refracción | n20D1.75 (Predicted) |
| Punto de ebullición (°C) | 153° C |
| Peso molecular | 423.400 g/mol |
| XLogP3 | 3.600 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 4 |
| Exact Mass | 423.111 Da |
| Monoisotopic Mass | 423.111 Da |
| Topological Polar Surface Area | 98.900 Ų |
| Heavy Atom Count | 32 |
| Formal Charge | 0 |
| Complexity | 850.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Guoting Su, Hui Xu, FangFang Zhou, Xiyu Gong, Songwen Tan, Yongju He. (2023) Boosting Reactive Oxygen Species Generation with a Dual-Catalytic Nanomedicine for Enhanced Tumor Nanocatalytic Therapy. ACS Applied Materials & Interfaces, [PMID:38095444] [10.1021/acsami.3c13882] |
| 2. Xingyu Fan, Xiyu Gong, Fangfang Zhou, Botao Chen, Songwen Tan, Hui Xu, Anqiang Pan, Shuquan Liang, Yongju He. (2022) Mesoporous peroxidase nanozyme for synergistic chemodynamic therapy and chemotherapy. COLLOIDS AND SURFACES B-BIOINTERFACES, [PMID:35653958] [10.1016/j.colsurfb.2022.112603] |
| 3. Linjie Shao, Taishun Hu, Xingyu Fan, Xiaozan Wu, Fangfang Zhou, Botao Chen, Songwen Tan, Hui Xu, Anqiang Pan, Shuquan Liang, Yongju He. (2022) Intelligent Nanoplatform with Multi Therapeutic Modalities for Synergistic Cancer Therapy. ACS Applied Materials & Interfaces, [PMID:35286061] [10.1021/acsami.2c01913] |
| 4. Li Cong, Lai Chaoyang, Qiu Qiujun, Luo Xiang, Hu Ling, Zheng Huangliang, Lu Yi, Liu Min, Zhang Hongxia, Liu Xinrong, Deng Yihui, Song Yanzhi. (2019) Dual-Ligand Modification of PEGylated Liposomes Used for Targeted Doxorubicin Delivery to Enhance Anticancer Efficacy. AAPS PHARMSCITECH, 20 (5): (1-13). [PMID:31093777] [10.1208/s12249-019-1385-0] |
| 5. Chaoyang Lai, Cong Li, Mengyang Liu, Qiujun Qiu, Xiang Luo, Xinrong Liu, Ling Hu, Yihui Deng, Yanzhi Song. (2018) Effect of Kupffer cells depletion on ABC phenomenon induced by Kupffer cells-targeted liposomes. Asian Journal of Pharmaceutical Sciences, [PMID:32104474] [10.1016/j.ajps.2018.07.004] |
| 6. Chaoyang Lai, Cong Li, Xiang Luo, Mengyang Liu, Xinrong Liu, Ling Hu, Le Kang, Qiujun Qiu, Yihui Deng, Yanzhi Song. (2018) Use of Dual-Ligand Modification in Kupffer Cell-Targeted Liposomes To Examine the Contribution of Kupffer Cells to Accelerated Blood Clearance Phenomenon. MOLECULAR PHARMACEUTICS, [PMID:29768009] [10.1021/acs.molpharmaceut.8b00042] |
| 7. Yongju He, Xiangjie Tian, Meiru Zhang, Hui Xu, Xiyu Gong, Binbin Yang, Fangfang Zhou. (2024) Fenton-like nanoparticles capable of H2O2 self-supply and glutathione consumption for chemodynamic and chemotherapy of cancer. Biomaterials Science, [PMID:39267609] [10.1039/D4BM00930D] |
| 8. Xiangjie Tian, Hui Xu, FangFang Zhou, Xiyu Gong, Songwen Tan, Yongju He. (2024) An Intelligent Cupreous Nanoplatform with Self-Supplied H2O2 and Cu2+/Cu+ Conversion to Boost Cuproptosis and Chemodynamic Combined Therapy. CHEMISTRY OF MATERIALS, [PMID:] [10.1021/acs.chemmater.3c02323] |
| 9. Meiru Zhang, Hui Xu, Xiaozan Wu, Botao Chen, Xiyu Gong, Yongju He. (2025) Engineering Dual-Responsive Nanoplatform Achieves Copper Metabolism Disruption and Glutathione Consumption to Provoke Cuproptosis/Ferroptosis/Apoptosis for Cancer Therapy. ACS Applied Materials & Interfaces, [PMID:40134095] [10.1021/acsami.4c22546] |
| 10. Jieming Zhang, Fangfang Zhou, Xin Du, Meiru Zhang, Suxiao Li, Songtao Niu, Qungang Chang, Yongju He. (2025) Tumor-Specific Activatable Nanopaltform Achieves Oxidative Stress Amplification and Reversal of Cisplatin Resistance to Provoke Enhanced Ferroptosis–Apoptosis Cancer Therapy. MOLECULAR PHARMACEUTICS, [PMID:40500911] [10.1021/acs.molpharmaceut.5c00406] |
