GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Benzaldehyde, 3-​methyl-​, 2-​[6-​(4-​morpholinyl)​-​2-​[2-​(2-​pyridinyl)​ethoxy]​-​4-​pyrimidinyl]​hydrazone

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Apilimod (STA-5326) Apilimod (STA-5326) is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod (STA-5326) inhibits
In vitro

Apilimod selectively inhibits TLR-induced cytokine expression. It selectively inhibits the production of IL12p40, whereas it has little effect on IL8 production in THP-1 cells. Apilimod reduces not only PtdIns(3,5)P₂ production but also that of PtdIns5P in intact cells.

In vivo

Cell Data

cell lines：

Concentrations：10 nM and 1 μM

Incubation Time：120 min

Powder Purity:≥99%

Specifications

Sinónimos

Benzaldehyde, 3-​methyl-​, 2-​[6-​(4-​morpholinyl)​-​2-​[2-​(2-​pyridinyl)​ethoxy]​-​4-​pyrimidinyl]​hydrazone

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Apilimod (STA-5326) is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod (STA-5326) inhibits IL-12 with IC50 of 1 n

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

1-phosphatidylinositol 3-phosphate 5-kinase inhibitor

Propiedades del producto

• ALogP: 3.8

Nombres e identificadores

• Isómeros SMILES: CC1=CC(=CC=C1)/C=N/NC2=CC(=NC(=N2)OCCC3=CC=CC=N3)N4CCOCC4
• Peso molecular: 418.49
• Reaxy-Rn: 18539732
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18539732&ln=

Objetivos asociados (humanos)

PIKFYVE Tchem 1-phosphatidylinositol 3-phosphate 5-kinase (2 Activities)

Discover Target: PIKFYVE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Punto de fusión (°C): 70-80° C