Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Protected from light,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 6 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Arecoline, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor . Arecoline exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline also can induce oxidative stress .
| pKa | pKa: 6.84 |
|---|---|
| Datos Ki | Muscarinic acetylcholine receptor M1: Ki= 3.33 nM (Mus musculus); Muscarinic acetylcholine receptor: Ki= 5.3 nM (rat); Muscarinic acetylcholine receptor M3: Ki= 7.4 nM (rat); Muscarinic acetylcholine receptor M4: Ki= 7.4 nM (rat) |
| Isómeros SMILES | CN1CCC=C(C1)C(=O)OC |
|---|---|
| CAS alternativo | 300-08-3 |
| Peso molecular | 155.19 |
| Reaxy-Rn | 123045 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=123045&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Índice de refracción | n20D1.48 (Predicted) |
|---|---|
| Punto de ebullición (°C) | 209° C |
| Punto de fusión (°C) | 27.46° C (Predicted) |
| 1. Ying Lu, Jianna Yu, Wen Liu, Guoxing Jing, Wenshan Li, Wenjie Liu. (2022) Quantitative determination of major alkaloids in areca nut products by high-performance liquid chromatography coupled with ion mobility spectrometry. JOURNAL OF SEPARATION SCIENCE, 45 (24): (4469-4477). [PMID:36250424] [10.1002/jssc.202200361] |
| 2. Yin Lifen, Wang Xiao. (2024) Curcumin Alleviates Arecoline-induced Oral Submucous Fibrosis via the FOSL1/MAPK8 Axis. CELL BIOCHEMISTRY AND BIOPHYSICS, [PMID:39674970] [10.1007/s12013-024-01633-x] |
| 3. Kaiping Xiang, Bing Wang, Lanying Wang, Yunfei Zhang, Hanzeng Li, Yanping Luo. (2024) Oxidative Stress, Oxidative Damage, and Cell Apoptosis: Toxicity Induced by Arecoline in Caenorhabditis elegans and Screening of Mitigating Agents. Toxins, 16 (8): (352). [PMID:39195762] [10.3390/toxins16080352] |
| 4. Sun Honglan, Yang Chao, Yin Xiaoyunqing, Chen Shizhao, Huang Yuqi, Kuang Huifang, Luo Wen. (2025) VHL ameliorates arecoline-induced oral submucosal fibrosis by promoting HDAC6 ubiquitination and blocking NF-κB pathway. Scientific Reports, 15 (1): (1-12). [PMID:40038412] [10.1038/s41598-025-91207-5] |
| 5. Yuejie Wu, Fei Wang, Longxiang Gao, Yunfei Zhang, Lanying Wang, Yanping Luo. (2025) Evaluation of the Intergenerational Effects of Arecoline on Aedes aegypti via Acute Exposure and Its Role in Inducing the Leg Deformities Involved in Chitin Synthesis Inhibition. ENVIRONMENTAL TOXICOLOGY, [PMID:41427474] [10.1002/tox.70013] |
| 6. Ting-Syuan Lin, Jingting Wan, Jingjin He, Shidong Cui, Yun Huang, Bojian Zhang, Hsi-Yuan Huang, Kexin Zhu, Jihang Chen, Tao Zhang, Shangfu Li, Liao Hu, Yongfei Wang, Hsien-Da Huang, Ping Tang, Yang-Chi-Dung Lin. (2026) Arecoline as a Novel Scaffold Targeting the ATAD2 Bromodomain for Cell Cycle Modulation. Pharmaceutics, 18 (3): (324). [PMID:] [10.3390/pharmaceutics18030324] |
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