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Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 44 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Artesunate (WR-256283) is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor ofSTAT-3and exhibits selective cytotoxicity of cancer cells over normal cells in vitro; A p
In vitro
ART could alter the biomechanical properties of the glioma cells to inhibit cell proliferation, migration and invasion .The ART significantly suppresses the cell proliferation, induces the apoptosis and promoted cell cycle arrest at G0/G1 phase in SKM-1 cells. The mechanisms of ART anti-MDS is associated with the increase of intracellular calciumion concentration and ROS levels. In addition, the pro-apoptotic activity of ART may be involved in the regulation of BCL-2 /BAX ratio and the expressions of P-bad and survivin. ART treatment demethylates CDH1, which, in turn recovers the E-cadherin activation in SKM-1 cells.
In vivo
Artesunate is a medication used to treat malaria. Artesunate can induce radiosensitivity of HeLa cells in vivo using Xenograft model of nude mice. Artesunate had a relatively high immunosuppressive activity with low toxicity, and could inhibit T lymphocyte proliferation induced by mitogen and alloantigen.
Cell Data
cell lines:
Concentrations:0, 12.5, 25, 50 µg/mL
Incubation Time:0, 24, 48, and 72 h
Powder Purity:≥97%
| ALogP | 2.5 |
|---|
| Isómeros SMILES | C[C@@H]1CC[C@H]2[C@H]([C@@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)OC(=O)CCC(=O)O)C |
|---|---|
| Peso molecular | 384.42 |
| Reaxy-Rn | 7496318 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7496318&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Solubilidad | Solubility (25°C) In vitro DMSO: 12 mg/mL (38.42 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|---|
| Rotación específica [α] | 5.5° (C=1,CH2Cl2) |
| Punto de fusión (°C) | 133°C |
| 1. Chenyu Zhao, Rong Wang, Siyuan Luo, Ya Wang, Zhenhai Gan, Jingran Di, Daocheng Wu. (2025) Molecular Stacking@Infinite Coordination Polymer Nanocomposites for Tumor Continuous High-Intensity Photothermal–Thermodynamic Alternate Cycle Therapy and Chemotherapy. ACS Nano, [PMID:40719356] [10.1021/acsnano.5c07772] |
| 2. Shichen Zhang, Lei Guo, Yixin Tang, Yixing Wang, Heshi Liu, Chang Liu, Xiuzhang Yan, Congcong Duan, Huanyan Dai, Bing Han, Caina Xu. (2025) Self-reinforced nanoreactor for apoptosis/ferroptosis synergistic therapy of head and neck squamous cell carcinoma. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2025.166941] |
| 3. Jingjing Zhen, Faguang Ma, Rongxin Lin, Ming Yan, Yilin Wu. (2023) Porous MOFs-based self-assembled membrane with specific rebinding nanocages for selective recognition and separation at molecular level. DESALINATION, [PMID:] [10.1016/j.desal.2023.117124] |
| 4. Weibai Bian, Ruixuan Zhang, Xiaohui Chen, Chuanxun Zhang, Minjia Meng. (2023) Three-Dimensional Porous PVDF Foam Imprinted Membranes with High Flux and Selectivity toward Artemisinin/Artemether. MOLECULES, 28 (21): (7452). [PMID:37959871] [10.3390/molecules28217452] |
| 5. Kaicheng Zhang, Rongxin Lin, Ming Yan, Yilin Wu. (2023) Click-chemistry synergic MXene-functionalized flexible skeleton membranes for accurate recognition and separation. JOURNAL OF COLLOID AND INTERFACE SCIENCE, [PMID:37690308] [10.1016/j.jcis.2023.09.028] |
| 6. Li Yuan-Ce, Zhang Qi, Zhang Hong-Yang, Wang Yan-Wen, Sun Yu-Mei, Yang Bi-Juan, Yin Jun-Lin. (2023) Artesunate, as an Hsp90 inhibitor, inhibits the proliferation of Burkitt’s lymphoma cells by inhibiting AKT and ERK. Frontiers in Pharmacology, [PMID:37719860] [10.3389/fphar.2023.1218467] |
| 7. Jing Yan, Faguang Ma, Yilin Wu. (2023) Permselective and transparent wooden membrane with artemisinin-imprinted nanocages based on a MOFs@C3N4 self-assembly design. Materials Today Nano, [PMID:] [10.1016/j.mtnano.2023.100369] |
| 8. Xin Zhang, Zhifang Liang, Ying Zhou, Fang Wang, Shan Wei, Bing Tan, Yujie Guo. (2023) Artesunate Inhibits Apoptosis and Promotes Survival in Schwann Cells via the PI3K/AKT/mTOR Axis in Diabetic Peripheral Neuropathy. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 46 (6): (764-772). [PMID:37258141] [10.1248/bpb.b22-00619] |
| 9. Minjia Meng, Yi Li, Hui Peng, Binrong Li, Chuanxun Zhang, Jiajia Ren, Qingluola Ren, Yan Liu, Jianming Pan. (2023) Hydrophilic imprinted MnO2 nanowires “coating” membrane with ultrahigh adsorption capacity for highly selective separation of Artemisinin/Artemether. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2023.143020] |
| 10. Jie Lv, Xiaoyu Wang, Xue Zhang, Runpei Xu, Shuyang Hu, Shuangling Wang, Meng Li. (2023) Tumor microenvironment-responsive artesunate loaded Z-scheme heterostructures for synergistic photo-chemodynamic therapy of hypoxic tumor. Asian Journal of Pharmaceutical Sciences, [PMID:37252037] [10.1016/j.ajps.2023.100798] |
| 11. Jing Yan, Kaicheng Zhang, Faguang Ma, Hang Cui, Yilin Wu. (2023) Scalable basswood-based PDA/GO-embedded self-assembly membrane within multilayered artemisinin-imprinted nanocage for high-selectivity cascading adsorption and transport. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2023.142277] |
| 12. Zhong Wenzhao, Guo Feng, Chen Fangman, Law Man-Kay, Lu Jun, Shao Dan, Yu Hua, Chan Ging, Chen Meiwan. (2022) A multifunctional oxidative stress nanoamplifier with ROS amplification and GSH exhaustion for enhanced chemodynamic therapy. Frontiers in Pharmacology, [PMID:36438812] [10.3389/fphar.2022.1044083] |
| 13. Peng Ji, Xianglong Wang, Jiabing Yin, Yansheng Yao, Wangqi Du. (2022) Amplification of ferroptosis with a liposomal nanoreactor cooperates with low-toxicity doxorubicin apoptosis for enhanced tumor chemotherapy. Biomaterials Science, 10 (6): (1544-1553). [PMID:35171184] [10.1039/D2BM00079B] |
| 14. Sennan Qiao, Hansi Zhang, Fei Sun, Zhenyan Jiang. (2021) Molecular Basis of Artemisinin Derivatives Inhibition of Myeloid Differentiation Protein 2 by Combined in Silico and Experimental Study. MOLECULES, 26 (18): (5698). [PMID:34577169] [10.3390/molecules26185698] |
| 15. Miaomiao Long, Jiamin Xu, Wenjie Fang, Jing Mao, Jie Zhang, Shenhuan Liu, Lipeng Qiu. (2021) Enhanced delivery of artesunate by stimuli-responsive polymeric micelles for lung tumor therapy. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, [PMID:] [10.1016/j.jddst.2021.102812] |
| 16. Fereja Shemsu Ligani, Fang Zhongying, Li Ping, Guo Jinhan, Fereja Tadesse Haile, Chen Wei. (2021) “Turn-off” sensing probe based on fluorescent gold nanoclusters for the sensitive detection of hemin. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 413 (6): (1639-1649). [PMID:33483839] [10.1007/s00216-020-03126-1] |
| 17. Mengqi Bai, Li Qiang, Minjia Meng, Binrong Li, Suao Wang, Yilin Wu, Li Chen, Jiangdong Dai, Yan Liu, Jianming Pan. (2020) Upper surface imprinted membrane prepared by magnetic guidance phase inversion method for highly efficient and selective separation of Artemisinin. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2020.126899] |
| 18. Huang Ming-Zhi, Zhuang Yong, Ning Xu, Zhang Hao, Shen Zhi-Min, Shang Xian-Wen. (2020) Artesunate inhibits osteoclastogenesis through the miR-503/RANK axis. BIOSCIENCE REPORTS, 40 (7): [PMID:32542308] [10.1042/BSR20194387] |
| 19. Yilin Wu, Wendong Xing, Minjia Meng, Jian Lu, Faguang Ma, Jia Gao, Xinyu Lin, Chao Yu. (2020) Multiple-functional molecularly imprinted nanocomposite membranes for high-efficiency selective separation applications: An imitated core-shell TiO2@PDA-based MIMs design. COMPOSITES PART B-ENGINEERING, [PMID:] [10.1016/j.compositesb.2020.108123] |
| 20. Zhu Wang, Qianqian Wang, Tao He, Wen Li, Yan Liu, Yuan Fan, Yanping Wang, Qi Wang, Jie Chen. (2020) The combination of artesunate and carboplatin exerts a synergistic anti-tumour effect on non-small cell lung cancer. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 47 (6): (1083-1091). [PMID:32072678] [10.1111/1440-1681.13287] |
| 21. Peng Ji, Haiqin Huang, Shirui Yuan, Le Wang, Siqi Wang, Yiwei Chen, Na Feng, Hanitrarimalala Veroniaina, Ziheng Wu, Zhenghong Wu, Xiaole Qi. (2019) ROS-Mediated Apoptosis and Anticancer Effect Achieved by Artesunate and Auxiliary Fe(II) Released from Ferriferous Oxide-Containing Recombinant Apoferritin. Advanced Healthcare Materials, 8 (23): (1900911). [PMID:31701665] [10.1002/adhm.201900911] |
| 22. Renjie Xu, Ting Han, Li Shen, Jianguo Zhao, Xiang’an Lu. (2019) Solubility Determination and Modeling for Artesunate in Binary Solvent Mixtures of Methanol, Ethanol, Isopropanol, and Propylene Glycol + Water. JOURNAL OF CHEMICAL AND ENGINEERING DATA, [PMID:] [10.1021/acs.jced.8b00988] |
| 23. Yao Yuyuan, Guo Qinglong, Cao Yue, Qiu Yangmin, Tan Renxiang, Yu Zhou, Zhou Yuxin, Lu Na. (2018) Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 37 (1): (1-14). [PMID:30477536] [10.1186/s13046-018-0960-7] |
| 24. Ting Li, Qingwen Zeng, Xingming Chen, Guojiang Wang, Haiqing Zhang, Aihua Yu, Hairui Wang, Yang Hu. (2018) The therapeutic effect of artesunate on rosacea through the inhibition of the JAK/STAT signaling pathway. Molecular Medicine Reports, 17 (6): (8385-8390). [PMID:29693177] [10.3892/mmr.2018.8887] |
| 25. Hailong Huang, Xianghui Wang, Hao Ge, Min Xu. (2016) Multifunctional Magnetic Cellulose Surface-Imprinted Microspheres for Highly Selective Adsorption of Artesunate. ACS Sustainable Chemistry & Engineering, [PMID:] [10.1021/acssuschemeng.6b00386] |
| 26. Hongqiao Wei, Yongxin Chen, Zhenmin Qin, Honglei Wang, Yujia Liu, Tang Song, Yong Wu, Wanxiang Hu, Xiaowei Huang, Guodong Lu, Jing Zhou. (2025) Artesunate demonstrates neuroprotective effect through activation of lysosomal function and inhibition of cGAS-STING pathway. NEUROPHARMACOLOGY, [PMID:40118208] [10.1016/j.neuropharm.2025.110426] |
| 27. Lirong Zhang, Beibei Yu, Zijian Zhuang, Zhengzou Fang, Mengke Lu, Huijun Yu, Xiao Xu, Xin Sun, Fengyi Du, Miaomiao Zhang. (2024) Autocatalytic Artesunate Coordinated ZIF-8 Nanoplatforms with Metal-Polyphenol Network Coating for Targeted Tumor Chemodynamic Therapy. ACS Applied Nano Materials, [PMID:] [10.1021/acsanm.4c00403] |
| 28. Wang Yun, Li Zhongrui, Li Renshi, Han Chao, Wang Lei. (2024) Berberine-based self-assembly agents with enhanced synergistic antitumor efficacy. Frontiers in Pharmacology, [PMID:38545553] [10.3389/fphar.2024.1333087] |
| 29. Wang Da, Bai Yunfei, Cheng Guogang, Shen Shengqiang, Xiao Gengwu, Ma Demei, Zhao Ganggang, Chen Wei, Li Tianshi, Zhang Litao, Ge Xiaohu. (2024) Exosome-drug conjugates delivery: a promising strategy for ameliorating the pharmacokinetic profile of artesunate. Frontiers in Bioengineering and Biotechnology, [PMID:39188369] [10.3389/fbioe.2024.1437787] |
| 30. Xiaoyu Wang, Chunzhe Xu, Hantao Tian, Yu Pang, Jie Lv, Meng Li. (2025) FeS embedded bioreactor collaborate with artesunate for cascade-catalytic tumor ferroptosis. JOURNAL OF COLLOID AND INTERFACE SCIENCE, [PMID:40184656] [10.1016/j.jcis.2025.137479] |
| 31. Yiqun Zhang, Ni Zhang, Jianghao Xing, Yiwei Sun, Xu Jin, Cailiang Shen, Liang Cheng, Yuanyin Wang, Xianwen Wang. (2024) In situ hydrogel based on Cu–Fe3O4 nanoclusters exploits oxidative stress and the ferroptosis/cuproptosis pathway for chemodynamic therapy. BIOMATERIALS, [PMID:38943822] [10.1016/j.biomaterials.2024.122675] |
| 32. Meiting Li, Zhuoyin Liu, Dan Peng, Yadong Liu, Lili Cheng, Baizhu Chen, Jie Liu. (2025) Multifunctional porous organic polymer-based hybrid nanoparticles for sonodynamically enhanced cuproptosis and synergistic tumor therapy. Acta Biomaterialia, [PMID:39993518] [10.1016/j.actbio.2025.02.045] |
| 33. Cijun Shuai, Gao Pan, Tiantian He, Xiong Shuai, Ping Wu, Qi Zhong. (2024) Photothermal effect of graphene oxide accelerate singlet oxygen release from artesunate to endow the scaffold with antibacterial properties. Materials Today Communications, [PMID:] [10.1016/j.mtcomm.2024.109058] |
| 34. Minjia Meng, Jiajia Ren, Chuanxun Zhang, Wanqi Du, Jixiang Wang. (2024) Polyvinylidene Fluoride-Based Nanowire-Imprinted Membranes with High Flux for Efficient and Selective Separation of Artemisinin/Artemether. MOLECULES, 29 (16): (3868). [PMID:39202947] [10.3390/molecules29163868] |
| 35. Jiahe Chen, Yingying Zhang, Xin Guo, Yiyang Qiao, Ping Yu. (2024) Three-dimensional porous imprinted UiO-66-D@loofah membrane for targeted separation of Artemisinin by smart situ deposition method. SEPARATION AND PURIFICATION TECHNOLOGY, [PMID:] [10.1016/j.seppur.2024.126523] |
| 36. Han-Xiao Tang, Zhi-Hang He, Chen-Guang Liu, Xiao-Ke Zheng, Zhi-Juan Zhang. (2024) Tumor Microenvironment-Responsive Biodegradable Nanomedicine for Self-Enhanced Synergistic Chemo-, Photothermal, and Chemodynamic Therapy. ACS Applied Materials & Interfaces, [PMID:39303011] [10.1021/acsami.4c09671] |
| 37. Jingru Cui, Zhonghui Xue, Zhengxian Zhang, Huanhuan Zhu, Mingsan Miao, Yagang Song, Xiaofang Li, Huahui Zeng, Xiangxiang Wu. (2025) GSH-Triggered Self-Cascading Nanoreactor Integrates Efficient ICD Induction and Immune Checkpoint Blockade for Pancreatic Cancer Therapy. ADVANCED FUNCTIONAL MATERIALS, [PMID:] [10.1002/adfm.202520855] |
| 38. Zhaoyang Gan, Chang Liu, Shaopeng Li, Chengda Ju, Sixuan Huo, Jing Wang, Yulong Lin. (2025) Artesunate loaded core-shell nanoplatform for the chemo-chemodynamic-photothermal synergistic cancer therapy. COLLOIDS AND SURFACES B-BIOINTERFACES, [PMID:40393095] [10.1016/j.colsurfb.2025.114810] |
| 39. Ji Hongyan, Huang Yutao, Tian Jingxuan, Bo Ruonan, Heng Xin, Yang Junyi, Huang Yifan, Wang Xiangyu, Tan Qingfeng, Gao Hua, Chen Linwei, Chen Jing. (2025) Chrysosplenetin acts as a homeostasis stabilizer with dual-function in shattering Plasmodium berghei K173 resistance to artemisinin driven by both ABC transporters and heme-ROS/GSH axis. Parasites & Vectors, 18 (1): (1-22). [PMID:41068871] [10.1186/s13071-025-07018-0] |
| 40. Chen Chen, Xinlu Li, Weixia Zhu, Yu Chen, Jie Tang, Shun Yao. (2025) The suppository containing a complex of active pharmaceutical ingredient-ionic liquid (API-IL) derived from mefloquine and artesunate with Zeolitic imidazolate framework-8. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2025.169534] |
| 41. Yijie Wang, Xinyu Yu, Xinyu Zhang, Xiaohui He, Yongxin Tang, Ling Fang, Richard Culleton, Qingfeng Zhang, Weifu Dong, Jun Cao. (2026) Development and evaluation of novel zein-based artemisinin sustained-release formulation for treating drug-resistant malaria. mBio, [PMID:41524404] [10.1128/mbio.03696-25] |
| 42. Xifan Zheng, Bo Yu, Yuansong Song, Yeping Chen, Zeming Li, Jun Yao. (2026) Artemisinin exerts anti-inflammatory effects in osteoarthritis through the inhibition of TGF-β1 signaling. Frontiers in Immunology, [PMID:41694337] [10.3389/fimmu.2026.1717045] |
| 43. Haonan Wu, Xuan Zhang, Xiaomei Shu, Hongyuan Zhang, Wenhu Zhou, Shenwu Zhang, Cong Luo. (2026) Molecularly Tailored Artesunate Nanomedicine with Well-Balanced Nanoassembly and Anticancer Performance. Pharmaceutics, 18 (2): (240). [PMID:41754981] [10.3390/pharmaceutics18020240] |
| 44. Enkang Tong, Xiaofei Dong, Yifan Ren, Lingxue Gong, Cuicui Zhao, Rongrong Nie, Xiangfeng Meng. (2026) Artesunate ameliorates Staphylococcus aureus-induced mandibular osteomyelitis and promotes osteogenic differentiation via NOD2/p65 signaling pathway. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:] [10.1016/j.intimp.2026.116472] |
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