Asimilobine , CAS No.6871-21-2

CAS: 6871-21-2 Cat. No.: A647685 Peso molecular: 267.32 Número EC: 881-576-8 PubChem CID: 160875

Synonyms

CHEBI:70637 | 6abeta-Noraporphin-2-ol, 1-methoxy- | DTXSID00988410 | Q4H26TGS8S | R-(-)-asimilobine | FS-8822 | UNII-Q4H26TGS8S | (6AR)-5,6,6A,7-TETRAHYDRO-1-METHOXY-4H-DIBENZO(DE,G)QUINOLIN-2-OL | 4H-Dibenzo(de,g)quinolin-2-ol, 5,6,6a,7-tetrahydro-1-meth

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity

In Vitro

Asimilobine (0.05-0.2 μM; for 24 h) shows a significant inhibition of intracellular dopamine levels in a concentration-dependent manner with an IC 50 value of 0.13 μM. Asimilobine (0.15 μM) inhibits tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) activities at 24 h. Asimilobine also decreases TH mRNA levels and intracellular cyclic AMP levels. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Plasmodium|Dopamine Receptor|serotonergic receptor

Specifications

Sinónimos

CHEBI:70637 | 6abeta-Noraporphin-2-ol, 1-methoxy- | DTXSID00988410 | Q4H26TGS8S | R-(-)-asimilobine | FS-8822 | UNII-Q4H26TGS8S | (6AR)-5, 6, 6A, 7-TETRAHYDRO-1-METHOXY-4H-DIBENZO(DE, G)QUINOLIN-2-OL | 4H-Dibenzo(de, g)quinolin-2-ol, 5, 6, 6a, 7-tetrahydro-1-meth

Mecanismos bioquímicos y fisiológicos

Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Nombres e identificadores

• Sonrisas canónicas: COC1=C(C=C2CCNC3C2=C1C4=CC=CC=C4C3)O
• IUPAC Name: (6aR)-1-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-2-ol
• InChIKey: NBDNEUOVIJYCGZ-CYBMUJFWSA-N
• INCHI: 1S/C17H17NO2/c1-20-17-14(19)9-11-6-7-18-13-8-10-4-2-3-5-12(10)16(17)15(11)13/h2-5,9,13,18-19H,6-8H2,1H3/t13-/m1/s1
• Isómeros SMILES: COC1=C(C=C2CCN[C@H]3C2=C1C4=CC=CC=C4C3)O
• PubChem CID: 160875
• Peso molecular: 267.32

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Alkaloids and derivatives
    • Clase Aporphines

• Kingdom: Organic compounds
• Superclass: Alkaloids and derivatives
• Clase: Aporphines
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Aporphines
• Alternative Parents: Phenanthrenes and derivatives Benzoquinolines Naphthols and derivatives Tetrahydroisoquinolines Anisoles Aralkylamines Alkyl aryl ethers 1-hydroxy-2-unsubstituted benzenoids Dialkylamines Azacyclic compounds Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Aporphine - Benzoquinoline - Phenanthrene - 2-naphthol - Naphthalene - Quinoline - Tetrahydroisoquinoline - Anisole - Alkyl aryl ether - 1-hydroxy-2-unsubstituted benzenoid - Aralkylamine - Benzenoid - Azacycle - Ether - Secondary aliphatic amine - Secondary amine - Organoheterocyclic compound - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Organic oxygen compound - Amine - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as aporphines. These are quinoline alkaloids containing the dibenzo[de,g]quinoline ring system or a dehydrogenated derivative thereof.
• External Descriptors: isoquinoline alkaloid

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HT-1080 (3966 Activities)

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SK-MEL-2 (46422 Activities)

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ZR-75-1 (953 Activities)

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A-431 (6446 Activities)

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KB (17409 Activities)

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LNCaP (8286 Activities)

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Objetivos asociados (no humanos)

Plasmodium falciparum (966862 Activities)

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P388 (20296 Activities)

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Mecanismos de acción

Propiedades químicas y físicas

• Peso molecular: 267.320 g/mol
• XLogP3: 2.600
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 267.126 Da
• Monoisotopic Mass: 267.126 Da
• Topological Polar Surface Area: 41.500 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 361.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1