Astaxanthin - ≥98%(HPLC), mixture of cis and trans , Antioxidant, anti-inflammatory and antiapoptotic activities, CAS No.472-61-7, Antioxidant, anti-inflammatory and antiapoptotic activities

CAS: 472-61-7 Cat. No.: A114383 Peso molecular: 596.84 Número EC: 207-451-4

GRADE & PURITY ≥98%(HPLC), mixture of cis and trans

Synonyms

DTXSID00893777 | Natupink | UNII-8XPW32PR7I | .beta.-Carotene-4,4'-dione, 3,3'-dihydroxy-, all-trans- | BCP05821 | CHEBI:40968 | LMPR01070263 | NSC-635689 | ASTAXANTHIN [WHO-DD] | 3S,3'S-Astaxanthin | Astaxanthin | SCHEMBL20047 | M01303 | trans-Astaxanthi

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

Astaxanthin (AST) is a red dietary carotenoid. It is mainly found in aquatic animals and microalgae, such as Haematococcus pluvialis and Chlorella zofingiensis.
Astaxanthin is a potent carotenoid antioxidant found in marine algae, red yeast and many other plant and animal sources. Animal studies indicate that it reduces blood glucose and ameliorates several parameters of the diabetic metabolic syndrome. It improves blood flow and vascular tone in models of hypertension. In vitro studies indicate that it upregulates connexin 43 and thus, may be chemopreventive against cancer.

Specifications

Sinónimos

DTXSID00893777 | Natupink | UNII-8XPW32PR7I | .beta.-Carotene-4, 4'-dione, 3, 3'-dihydroxy-, all-trans- | BCP05821 | CHEBI:40968 | LMPR01070263 | NSC-635689 | ASTAXANTHIN [WHO-DD] | 3S, 3'S-Astaxanthin | Astaxanthin | SCHEMBL20047 | M01303 | trans-Astaxanthi

Especificaciones y pureza

≥98%(HPLC), mixture of cis and trans

Mecanismos bioquímicos y fisiológicos

Astaxanthin is a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity. Astaxanthin protects against oxidative stress, inhibiting NF-KB, suppressing pro-inflammatory genes and suppressing production of pro-inflammatory

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Mecanismo de acción

Antioxidant, anti-inflammatory and antiapoptotic activities

Pureza

≥98%(HPLC)

Propiedades del producto

• ALogP: 10.3

Nombres e identificadores

• Sonrisas canónicas: CC1=C(C(CC(C1=O)O)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2=C(C(=O)C(CC2(C)C)O)C)C)C
• IUPAC Name: (6S)-6-hydroxy-3-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(4S)-4-hydroxy-2,6,6-trimethyl-3-oxocyclohexen-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-2,4,4-trimethylcyclohex-2-en-1-one
• InChIKey: MQZIGYBFDRPAKN-UWFIBFSHSA-N
• INCHI: 1S/C40H52O4/c1-27(17-13-19-29(3)21-23-33-31(5)37(43)35(41)25-39(33,7)8)15-11-12-16-28(2)18-14-20-30(4)22-24-34-32(6)38(44)36(42)26-40(34,9)10/h11-24,35-36,41-42H,25-26H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,27-15+,28-16+,29-19+,30-20+/t35-,36-/m0/s1
• Isómeros SMILES: CC1=C(C(C[C@@H](C1=O)O)(C)C)/C=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C2=C(C(=O)[C@H](CC2(C)C)O)C)\C)\C)/C)/C
• WGK Alemania: 3
• CAS alternativo: 7542-45-2
• Peso molecular: 596.84
• Reaxy-Rn: 11489489
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11489489&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Clase Prenol lipids
      • Subclass Tetraterpenoids
        • Level5 Carotenoids
          • Level6 Xanthophylls

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Clase: Prenol lipids
• Subclass: Tetraterpenoids
• Intermediate Tree Nodes: Carotenoids
• Direct Parent: Xanthophylls
• Alternative Parents: Cyclohexenones Secondary alcohols Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aliphatic homomonocyclic compounds
• Substituents: Xanthophyll - Cyclohexenone - Cyclic ketone - Secondary alcohol - Ketone - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Alcohol - Aliphatic homomonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as xanthophylls. These are carotenoids containing an oxygenated carotene backbone. Carotenes are characterized by the presence of two end-groups (mostly cyclohexene rings, but also cyclopentene rings or acyclic groups) linked by a long branched alkyl chain. Carotenes belonging form a subgroup of the carotenoids family. Xanthophylls arise by oxygenation of the carotene backbone.
• External Descriptors: C40 isoprenoids (tetraterpenes)

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

Discover Target: SLCO1B3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• Sensibilidad: light and air sensitive
• Punto de fusión (°C): 215-216°C
• Peso molecular: 596.800 g/mol
• XLogP3: 10.300
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 10
• Exact Mass: 596.387 Da
• Monoisotopic Mass: 596.387 Da
• Topological Polar Surface Area: 74.600 Ų
• Heavy Atom Count: 44
• Formal Charge: 0
• Complexity: 1340.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 9
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 9
• Covalently-Bonded Unit Count: 1

Referencias

1. Lei Diao, Wenjie Liu, Yawei Xu, Bin Zhang, Lingnan Meng, Rui Yin, Huijie Chen.  (2023)  New insights into micro-algal astaxanthin's effect on deoxynivalenol-induced spleen lymphocytes pyroptosis in Cyprinus carpio: Involving mitophagy and mtROS-NF-κB-dependent NLRP3 inflammasome.  FISH & SHELLFISH IMMUNOLOGY,      [PMID:38040132] [10.1016/j.fsi.2023.109259]

2. Pengjing Zhang, Yuanda Sun, Yitong Hou, Haitao Wang, Mingqian Tan.  (2023)  Fabrication of novel W/O/W emulsion gels using beeswax stabilized W/O: Preparation, characterization and co-delivery of phycocyanin and astaxanthin.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2023.103536]

3. Zi-Xu Zhang, Lu-Wei Xu, Ying-Shuang Xu, Jin Li, Wang Ma, Xiao-Man Sun, He Huang.  (2023)  Integration of genetic engineering and multi-factor fermentation optimization for co-production of carotenoid and DHA in Schizochytrium sp.  BIORESOURCE TECHNOLOGY,      [PMID:38154734] [10.1016/j.biortech.2023.130250]

4. Lei Diao, Meiqi Ding, Hongzhen Sun, Yawei Xu, Rui Yin, Huijie Chen.  (2023)  Micro-algal astaxanthin ameliorates polystyrene microplastics-triggered necroptosis and inflammation by mediating mitochondrial Ca2+ homeostasis in carp’s head kidney lymphocytes (Cyprinus carpio L.).  FISH & SHELLFISH IMMUNOLOGY,      [PMID:37918582] [10.1016/j.fsi.2023.109205]

5. Swagata Dutta, S.P. Jeevan Kumar, Rintu Banerjee.  (2023)  A comprehensive review on astaxanthin sources, structure, biochemistry and applications in the cosmetic industry.  Algal Research-Biomass Biofuels and Bioproducts,      [PMID:] [10.1016/j.algal.2023.103168]

6. Dong Su, Junkui Miao, Xiaofang Liu, Xixi Wang, Yuan Yu, Kailiang Leng, Yueqin Yu.  (2023)  Separation and concentration of phospholipids and glycerides from ethanol extraction of krill by hydration and solvent partitioning.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2023.123900]

7. Yingyuan Zhao, Zhaoxuan Wang, Shuxian Liu, Shiying Xie, Yinchun Xie, Ruifang Li, Hiroaki Oda.  (2023)  Lyoprotectant Formulation and Optimization of the J-Aggregates Astaxanthin/BSA/Chitosan Nanosuspension.  Biomolecules,  13  (3): (496).  [PMID:36979431] [10.3390/biom13030496]

8. Xin-Nan Teng, Shu-Chang Wang, Liaqat Zeb, Yue-Sheng Dong, Zhi-Long Xiu.  (2023)  Two-Step Enzymolysis of Antarctic Krill for Simultaneous Preparation of Value-Added Oil and Enzymolysate.  Marine Drugs,  21  (1): (47).  [PMID:36662220] [10.3390/md21010047]

9. Yu Fei, Chen Jiaxin, Wei Zizhan, Zhu Pingchuan, Qing Qing, Li Bangda, Chen Huimin, Lin Weiying, Yang Hua, Qi Zhongquan, Hong Xuehui, Chen Xiao Dong.  (2022)  Preparation of carrier-free astaxanthin nanoparticles with improved antioxidant capacity.  Frontiers in Nutrition,      [PMID:36245512] [10.3389/fnut.2022.1022323]

10. Sun Xixi, Yuan Yujie, Chen Qitong, Nie Shiqi, Guo Jiaxuan, Ou Zutian, Huang Min, Deng Zixin, Liu Tiangang, Ma Tian.  (2022)  Metabolic pathway assembly using docking domains from type I cis-AT polyketide synthases.  Nature Communications,  13  (1): (1-12).  [PMID:36130947] [10.1038/s41467-022-33272-2]

11. Zhi-Ang Liu, Ya-Nan Zuo, Yinghui Xia, Jing Sun, Shuyun Zhu.  (2022)  Enhanced detection of ascorbic acid with cascaded fluorescence recovery of a dual-nanoquencher system.  Analytical Methods,  14  (37): (3632-3637).  [PMID:36052693] [10.1039/D2AY01019D]

12. Yan Li, Kun Hu, Chao Huang, Yong Hu, Hongwu Ji, Shucheng Liu, Jing Gao.  (2022)  Improvement of solubility, stability and antioxidant activity of carotenoids using deep eutectic solvent-based microemulsions.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:35679734] [10.1016/j.colsurfb.2022.112591]

13. Shi Zhihui, He Xiaoxian, Zhang Hailiang, Guo Xuena, Cheng Yanfei, Liu Xuelian, Wang Zhaoyue, He Xiuping.  (2022)  Whole Genome Sequencing and RNA-seq-Driven Discovery of New Targets That Affect Carotenoid Synthesis in Phaffia rhodozyma.  Frontiers in Microbiology,      [PMID:35387079] [10.3389/fmicb.2022.837894]

14. Hang-Zhi Zhu, Shan Jiang, Jun-Jie Wu, Xue-Rong Zhou, Peng-Yang Liu, Feng-Hong Huang, Xia Wan.  (2022)  Production of High Levels of 3S,3′S-Astaxanthin in Yarrowia lipolytica via Iterative Metabolic Engineering.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:35191700] [10.1021/acs.jafc.1c08072]

15. Lijun Ding, Jie Yang, Kangrui Yin, Hao Cheng, Jing Li, Changhu Xue.  (2022)  The spatial arrangement of astaxanthin in bilayers greatly influenced the structural stability of DPPC liposomes.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:35131712] [10.1016/j.colsurfb.2022.112383]

16. Shujie Wang, Kefei Chen, Guoqin Liu.  (2021)  Monoglyceride oleogels for lipophilic bioactive delivery – Influence of self-assembled structures on stability and in vitro bioaccessibility of astaxanthin.  FOOD CHEMISTRY,      [PMID:34952389] [10.1016/j.foodchem.2021.131880]

17. Zhipeng Qi, Xianyu Fan, Chunyi Zhu, Dongsheng Chang, Jianjun Pei, Linguo Zhao.  (2021)  Overexpression and Characterization of a Novel Plant Carotenoid Cleavage Dioxygenase 1 from Morus notabilis.  CHEMISTRY & BIODIVERSITY,  19  (2): (e202100735).  [PMID:34821468] [10.1002/cbdv.202100735]

18. Ru Song, Yu Qi, Zhe Jia, Xinyan Liu, Rongbian Wei.  (2020)  Astaxanthin-loaded zein/calcium alginate composite microparticles: Characterization, molecular interaction and release kinetics in fatty food simulant system.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2020.110146]

19. Jianfeng Mei, Xiaoyun Zhao, Yu Yi, Yanlu Zhang, Xudong Wang, Guoqing Ying.  (2020)  Preparation of astaxanthin by lipase-catalyzed hydrolysis from its esters in a slug-flow microchannel reactor.  PROCESS BIOCHEMISTRY,      [PMID:] [10.1016/j.procbio.2020.06.017]

20. Xujian Qiu, Yumeng Wu, Shengjun Chen, Lechang Sun, Guangming Liu, Hong Lin.  (2020)  Oxidative Stability and Browning Development of Semi-dried Shrimp (Acetes chinensis) with Different Salt Contents and Packaging Methods Stored at Refrigerated Temperature.  FOOD SCIENCE AND TECHNOLOGY RESEARCH,      [PMID:] [10.3136/fstr.26.239]

21. Yunchang Fan, Zeyu Niu, Chen Xu, Lei Yang, Feiyang Chen, He Zhang.  (2019)  Biocompatible protic ionic liquids-based microwave-assisted liquid-solid extraction of astaxanthin from Haematococcus pluvialis.  INDUSTRIAL CROPS AND PRODUCTS,      [PMID:] [10.1016/j.indcrop.2019.111809]

22. Yanbin Wang, Yao Liu, Yuchen Li, Binbing Liu, Pei Wu, Shancai Xu, Huaizhang Shi.  (2018)  Protective effects of astaxanthin on subarachnoid hemorrhage-induced early brain injury: Reduction of cerebral vasospasm and improvement of neuron survival and mitochondrial function.  ACTA HISTOCHEMICA,      [PMID:30392635] [10.1016/j.acthis.2018.10.014]

23. Zhi-Wei Liu, Xin-An Zeng, Jun-Hu Cheng, De-Bao Liu, Rana Muhammad Aadil.  (2018)  The efficiency and comparison of novel techniques for cell wall disruption in astaxanthin extraction from Haematococcus pluvialis.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  53  (9): (2212-2219).  [PMID:] [10.1111/ijfs.13810]

24. Dan Xie, Hongyan Mu, Tianpei Tang, Xiaosan Wang, Wei Wei, Jun Jin, Xingguo Wang, Qingzhe Jin.  (2017)  Production of three types of krill oils from krill meal by a three-step solvent extraction procedure.  FOOD CHEMISTRY,      [PMID:29329855] [10.1016/j.foodchem.2017.12.068]

25. Tian Ma, Yuanjie Zhou, Xiaowei Li, Fayin Zhu, Yongbo Cheng, Yi Liu, Zixin Deng, Tiangang Liu.  (2015)  Genome mining of astaxanthin biosynthetic genes from Sphingomonas sp. ATCC 55669 for heterologous overproduction in Escherichia coli.  Biotechnology Journal,  11  (2): (228-237).  [PMID:26580858] [10.1002/biot.201400827]

26. Jingwen Han, Jiamin Ye, Jiacheng Shi, Yueyue Fan, Xue Yuan, Ruiyan Li, Gaoli Niu, Muhammad Abubakar, Yong Kang, Xiaoyuan Ji.  (2024)  A Programmable Oral Nanomotor Microcapsule for the Treatment of Inflammatory Bowel Disease.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202413261]

27. Shujie Cheng, Shimin Wu.  (2024)  A shelf life prediction method for butter based on the effects of β-carotene on colour and oxidative stability.  INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY,  77  (3): (961-972).  [PMID:] [10.1111/1471-0307.13078]

28. Xiuping Lin, Chang-sheng Shao, Shereen M. Elsherbiny, Qing Huang.  (2024)  Astaxanthin attenuates UV-irradiation aging process via activating JNK-1/DAF-16 in Caenorhabditis elegans.  PHOTOCHEMISTRY AND PHOTOBIOLOGY,      [PMID:38695248] [10.1111/php.13958]

29. Yahui Wu, Mona Alrasheed Bashir, Changsheng Shao, Han Wang, Jianxia Zhu, Qing Huang.  (2024)  Astaxanthin targets IL-6 and alleviates the LPS-induced adverse inflammatory response of macrophages.  Food & Function,      [PMID:38512055] [10.1039/D4FO00610K]

30. Shujie Cheng, Shimin Wu, Jianqiang Lan.  (2024)  Beta-carotene and astaxanthin inhibit the formation of polycyclic aromatic hydrocarbons and oxygenated polycyclic aromatic hydrocarbons in butter during heat treatment.  INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY,      [PMID:] [10.1111/1471-0307.13158]

31. Shujie Wang, Yuyue Qin, Yaping Liu, Guoqin Liu, Guiguang Cheng, Thanapop Soteyome.  (2024)  Controlling release of astaxanthin in β-sitosterol oleogel-based emulsions via different self-assembled mechanisms and composition of the oleogelators.  FOOD RESEARCH INTERNATIONAL,      [PMID:38729698] [10.1016/j.foodres.2024.114350]

32. Na Li, Yefan Wang, Zhifeng Tan, Yunpeng Xu, Xiaoyang Liu, Yuxin Liu, Dayong Zhou, Deyang Li.  (2024)  Effect of ultra-high pressure heat-assisted technology combined with L-cysteine on the color of ready-to-eat shrimp during storage.  FOOD CHEMISTRY,      [PMID:39079355] [10.1016/j.foodchem.2024.140634]

33. Xiaorong Huang, Ru Tan, Zhi Geng, Tao Zhang, Guangpeng Feng, Gang Yang, Feng Zhao, Ping Zhuang.  (2024)  Effects of Antarctic Krill Meal in Diet on Reproductive Performance and Embryo Quality of Eriocheir sinensis.  AQUACULTURE NUTRITION,      [PMID:38328024] [10.1155/2024/9936529]

34. Xue Qin, Menghao Yang, Xiaolin Wang, Haoqi Xiao, Chaoyue Cao, Jiawen Chai, Weijun Pang.  (2024)  Effects of Astaxanthin on oxidative stress of sows and piglet growth performances.  Livestock Science,      [PMID:] [10.1016/j.livsci.2024.105500]

35. Yuanzhao Wu, Ye'anlun Zhu, An Cheng, Weixuan Yao, Binjie Wang, Ruonan Zheng, Jiye Wang.  (2025)  Effects of tefluthrin exposure on early life stages in zebrafish: Insights into cardiac and skeletal development, oxidative stress and apoptosis.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:39978106] [10.1016/j.ecoenv.2025.117931]

36. Jiayan Du, Youtong Bao, Jingyuan Zhu, Xueqing Pang, Depeng Ren, Xinjian Yin, Pingping Zhou.  (2025)  Engineering of β-carotene hydroxylase for enhanced astaxanthin production in Saccharomyces cerevisiae.  BIOCHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.bej.2025.109722]

37. Chao Wang, Wang Ma, Luwei Xu, Zhiyun Wei, Ke Tang, Jingwen Zhou, Jian Chen.  (2024)  Integrative metabolic engineering and cellular organelle engineering for improving biosynthesis of flavonoid compounds in saccharomyces cerevisiae.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2024.103996]

38. Na Li, Xin Fan, Yefan Wang, Kexin Zhang, Rong Liu, Yunpeng Xu, Zhifeng Tan, Wensi Xu, Dayong Zhou, Deyang Li.  (2024)  Investigation of isomerization and oxidation of astaxanthin in ready-to-eat Litopenaeus vannamei during accelerated storage.  FOOD RESEARCH INTERNATIONAL,      [PMID:39277244] [10.1016/j.foodres.2024.114983]

39. Liu Kangjing, Tian Xueying, Fei Siyuan, Song Yukun, Abd El-Aty A. M., Tan Mingqian.  (2025)  Macrophage and mitochondrion dual-targeting astaxanthin nanoparticles prepared by Maillard reaction for colonic inflammation alleviation.  Marine Life Science & Technology,      [PMID:40417255] [10.1007/s42995-024-00255-9]

40. Kaixuan Ke, Ling Guo, Zhipeng Qi, Dou Dou, Han Ma, Xianying Fang, Linguo Zhao.  (2024)  Molecular cloning, expression, and biochemical characterization of carotenoid cleavage dioxygenase 1 (LbCCD1) from Lycium barbarum.  Molecular Catalysis,      [PMID:] [10.1016/j.mcat.2024.114561]

41. Lijuan Zhang, Shan Sun, Wentao Su, Mingqian Tan.  (2024)  Preventive effect of sea bass protein-based high internal phase Pickering emulsion loaded with astaxanthin on DEHP-induced liver lipid metabolism disorder.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39732256] [10.1016/j.ijbiomac.2024.139190]

42. Wenxuan Jiang, Xiangrong Deng, Lanxian Qin, Dahai Jiang, Mengqi Lu, Kai Chen, Manqi Yang, Liangliang Zhang, Jianchun Jiang, Liming Lu.  (2024)  Research on the Cell Wall Breaking and Subcritical Extraction of Astaxanthin from Phaffia rhodozyma.  MOLECULES,  29  (17): (4201).  [PMID:39275049] [10.3390/molecules29174201]

43. Xiaoting Yu, Yannan Chen, Mingqian Tan.  (2024)  ROS-responsive carboxymethyl chitosan nanoparticles loaded with astaxanthin for alleviating oxidative damage in intestinal cells.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:38744080] [10.1016/j.colsurfb.2024.113960]

44. Yafang Li, Jia Wei, Xiaofang Liang, Jiangping Wang, Sisi Yan, Lemei Zhu, Zhen Ding, Chunhua Zhan, Xiaoya Ren, Fei Yang.  (2025)  Sphingopyxis sp. YF1 and metabolite astaxanthin alleviate MC-LR-induced kidney injury.  PROCESS SAFETY AND ENVIRONMENTAL PROTECTION,      [PMID:] [10.1016/j.psep.2025.106982]

45. Jia Jianping, Chen Zhitao, Li Qingqing, Li Feifei, Liu Siru, Bao Guoliang.  (2024)  The enhancement of astaxanthin production in Phaffia rhodozyma through a synergistic melatonin treatment and zinc finger transcription factor gene overexpression.  Frontiers in Microbiology,      [PMID:38666259] [10.3389/fmicb.2024.1367084]

46. Shiji Xue, Yu Qiao, Hetian Jia, Yi Yang, Linge Shi, Zijie Zhang, Yue’e Peng, Wei Guo.  (2025)  Discrimination of Microalgal Cellular Metabolic Heterogeneity and 13C Metabolic Flux Analysis via Micro Label-Free Mass Cytometry.  ANALYTICAL CHEMISTRY,      [PMID:40808317] [10.1021/acs.analchem.5c03905]

47. Jianping Jia, Chenxi Ye, Sainan Jin, Qingqing Li, Zhengyi Pan, Wen Wen, Guoliang Bao.  (2025)  A transcriptome-guided genetic engineering strategy to balance cell growth with astaxanthin production in Phaffia rhodozyma.  Frontiers in Microbiology,      [PMID:41048484] [10.3389/fmicb.2025.1636554]

48. Xiumin Zhang, Mahwish Shaukat, Ronggang Liu, Liyang Peng, Yuxiao Wang, Wentao Su, Yukun Song, Mingqian Tan.  (2024)  Orally administered dual-targeted astaxanthin nanoparticles as novel dietary supplements for alleviating hepatocyte oxidative stress.  Food & Function,      [PMID:38305460] [10.1039/D3FO05319A]

49. Xiaoting Yu, Xunyu Song, Yannan Chen, Yueqi Lv, Mingqian Tan.  (2025)  Mitochondria-targeted astaxanthin prevents oxidative stress in intestinal crypt epithelial cells by regulating redox balance and mitophagy.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2025.106537]

50. Xiumin Zhang, Ronggang Liu, Yannan Chen, Huihui Wang, Wentao Su, Yukun Song, Mingqian Tan.  (2025)  Dual-Targeted Nanoparticles Hitchhiking on Lactobacillus rhamnosus Bacterial Ghosts to Alleviate Nonalcoholic Steatohepatitis.  ACS Nano,      [PMID:40179362] [10.1021/acsnano.4c18280]

51. Chunran Han, Xintong Zhang, Chenchen Li, Jiaqi Sui, Xin Wang, Diaomei Ma, Jingyang Wang, Qi An.  (2025)  High-cis astaxanthin nano lipid carrier: Preparation and bioavailability analysis.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2025.106780]

52. Ma Xue-Ke, Shao Xin, Xu Tian, Yan Hong, Teng Hui, Chen Zhe-Xin, Hu Meng-Xin.  (2025)  New Horizons of Astaxanthin-loaded Akkermansia muciniphila as an Integrated Dietary Supplement: Physicochemical Structures and Gastrointestinal Fate.  Probiotics and Antimicrobial Proteins,      [PMID:40369398] [10.1007/s12602-025-10572-9]

53. Xie Dan, Wang Taiwei, Yang Yunyun, Luo Jingru, Zheng Liyou, Zhang Yu, Ke Jiawei, Xie Liangliang, Jin Jun.  (2025)  Exploring the effect of Antarctic krill oil composition on its oxidation behavior based on three different lipid fractions.  EUROPEAN FOOD RESEARCH AND TECHNOLOGY,      [PMID:] [10.1007/s00217-025-04766-2]

54. Xuehan Jin, Shengfu Liu, Jiaqi Fang, Feng Chen, Bo Xu, Liping Nan, Shihong Zhao, Zhong Wu, Zhiyuan Guan, Kun Tao, Junjian Liu.  (2025)  Optimally Aligned Nerve Scaffolds with Sustained Astaxanthin Release Improve the Inflammatory Microenvironment through Mitophagy Activation.  Small,      [PMID:40370272] [10.1002/smll.202502939]

55. Xuedi Zhang, Yangyang, Meng Jiao, Dongmei Li.  (2025)  Astaxanthin-loaded high internal phase Pickering emulsion prepared using water-soluble protein complex from Antarctic krill: Construction and primary application in 3D printing.  FOOD RESEARCH INTERNATIONAL,      [PMID:40597495] [10.1016/j.foodres.2025.116773]

56. Shuo Diao, Guanrong Feng, Yixuan Wang, Jingming Ma, Zhihua Lv, Mingming Yu, Yue Sun.  (2025)  Development of an LC-MS/MS method for astaxanthin quantification in shrimp tissues and its application to detect astaxanthin variations during ovary development stages.  Frontiers in Nutrition,      [PMID:40621424] [10.3389/fnut.2025.1586625]

57. Xueyuan Li, Yaru Du, Niqian Du, Shanshan Du, Tianxiao Liu, Kaikai Liu, Zhiyong Liu.  (2025)  Improved ultraviolet resistant through the natural antioxidants in efficient perovskite photovoltaics.  CURRENT APPLIED PHYSICS,      [PMID:] [10.1016/j.cap.2025.05.014]

58. Kaixuan Ke, Yufeng Zhang, Xinyi Wang, Zhaoyan Luo, Yangyang Chen, Xianying Fang, Linguo Zhao.  (2025)  Identification, Cloning, and Functional Characterization of Carotenoid Cleavage Dioxygenase (CCD) from Olea europaea and Ipomoea nil.  Biology-Basel,  14  (7): (752).  [PMID:40723313] [10.3390/biology14070752]

59. Haibin Lai, Qi'’an Yu, Yuya Liu, Zhiwei Liang, Yating Li, Jinheng Pan, Jing Gao.  (2025)  Three-phase systems for simultaneous extraction and separation of bioactives from Haematococcus pluvialis: Role of thermo-switchable phase behavior.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2025.135755]

60. Moyu Zhong, Xinxin Huang, Xinyue Zhang, Zahid Hussain, Zhaohui Zan, Qi Wang, Xiulan Xie, Maozhi Ren.  (2025)  Synergistic Effects of Dysmorphococcus globosus on Selenium Enrichment and Astaxanthin Accumulation.  Foods,  14  (18): (3249).  [PMID:41008220] [10.3390/foods14183249]

61. Chenchen Li, Xintong Zhang, Weiye Xiu, Mingfu Yuan, Jingyang Wang, Diaomei Ma, Chunran Han.  (2025)  pH/glutathione dual-responsive magnetic carboxymethyl chitosan nanoparticles for the controlled release of astaxanthin.  Innovative Food Science & Emerging Technologies,      [PMID:] [10.1016/j.ifset.2025.104351]

62. Xin Wenyuan, Zhou Yunbing, Liu Daixi, Wang Cong, Sherwin K. B. Sy.  (2025)  1H NMR Quantification of Astaxanthin and Vitamin E in Nutritional Supplement.  Journal of Ocean University of China,  24  (6): (1827-1833).  [PMID:] [10.1007/s11802-025-6161-z]

63. Cheng Shun, Chi Mei-Li, Jiang Wen-Ping, Zheng Jian-Bo, Liu Shi-Li, Zhu Chao, Hang Xiao-Ying, Peng Miao, Li Fei.  (2025)  Research on the Application of Green Ecological Additive Combinations During the Breeding Period of Redclaw Crayfish.  Aquaculture, Fish and Fisheries,  5  (5): (e70124).  [PMID:] [10.1002/aff2.70124]

64. Yahui Wu, Qing Huang.  (2025)  Astaxanthin mitigates the inflammatory toxicity of microcystin-LR on zebrafish embryos.  COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,      [PMID:41270878] [10.1016/j.cbpc.2025.110399]

65. Hu Jiayao, Liu Hao, Wu Yizhou, Dong Xiaoyan, Tang Dongying, Yan Wei, Liu Bin, Zhou Hongyan.  (2025)  Astaxanthin and Dihydroartemisinin loaded PLGA NPs for atherosclerosis therapy via regulating lipid metabolism and immune microenvironment.  JOURNAL OF NANOBIOTECHNOLOGY,      [PMID:41327214] [10.1186/s12951-025-03830-z]

66. Honglin Jiang, Xinwen Wang, Junzhe Shang, Yiwen Bao, Jiaxin Li, Yifan Guo, Dongnan Li, Bin Li, Xu Si, Jinyan Zhu.  (2025)  Trehalose Coating for the Improved Raw Food Quality of Salmon under Ultra-High-Pressure Treatment: Texture, Flavor and Safety.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2025.118929]

67. Zhong Huichang, Chen Liyi, Liu Weifeng, Tao Yong.  (2025)  Screening and characterization of a high-astaxanthin-producing Xanthophyllomyces dendrorhous strain TP-4 via an efficient evolutionary-enrichment system.  ARCHIVES OF MICROBIOLOGY,  208  (1): (1).  [PMID:41191067] [10.1007/s00203-025-04534-6]

68. Jiamin Wang, Qifa Huang, Zihao Huang, Haoyue Hou, Jiawei Hou, Kaihui Xu, Hao Yuan, Sa Zeng, Tao Meng.  (2026)  UV filter-loaded mesoporous silica nanoparticles-stabilized Pickering emulsions with improved UV protection and ROS inhibition.  JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY,      [PMID:] [10.1016/j.jiec.2025.11.045]

69. Feng Cai, Wenting Lin, Jianqin Chen, Xiaoxu Zhao, Minghua Liu, Guotao Chen, Acong Chen, Yidi Chen, Jianhui Huang.  (2026)  Mechanistic insights into developmental neurotoxicity in zebrafish induced by environmental-level risperidone exposure: An integrated transcriptomic and metabolomic study.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:41534353] [10.1016/j.ecoenv.2026.119736]

70. Tianyi Chen, Fengjun Fan, An Cheng, Yumei Xia, Haoze Chen, Jiakai Fang, Yangyu Chen, Tianjia Li, Anli Wang, Binjie Wang, Weixuan Yao, Yuanzhao Wu.  (2026)  Flocoumafen exposure induces skeletal developmental toxicity and neurotoxicity in zebrafish (Danio rerio).  TOXICOLOGY LETTERS,      [PMID:41643754] [10.1016/j.toxlet.2026.111852]

71. Jian Ma, Feihong Jia, Jiangfeng Song, Dajing Li, Wuyang Huang, Ning Jiang, Haiyan Liu, Yanhong Ma.  (2026)  Astaxanthin Encapsulation in Zein/Chito-Oligosaccharide Composite Nanoparticles: Characterization, Stability, Antioxidant Efficacy and Bioaccessibility.  JOURNAL OF FOOD SCIENCE,  91  (2): (e70894).  [PMID:41618745] [10.1111/1750-3841.70894]

72. Yangcheng Ge, Yingcong Yang, Zhen Xu, Gongshuai Song, Mengna Zhang, Jinyan Gong.  (2026)  Glycation regulation between dual-natural milk-derived proteins and fucoidan by dielectric barrier discharge-cold plasma and its potential for delivery of astaxanthin.  Innovative Food Science & Emerging Technologies,      [PMID:] [10.1016/j.ifset.2026.104481]

73. Qinglin Qu, Fan Liu, Huajing Gao, Xiangrui Kong, Xue Gao, Yukun Song, Mingqian Tan, Yannan Chen, Dapeng Li, Xintong Tan.  (2026)  Orally engineered liver-targeted garlic exosome-like nanovesicles for astaxanthin precise delivery against alcoholic liver disease in mice.  FOOD RESEARCH INTERNATIONAL,      [PMID:] [10.1016/j.foodres.2026.119022]

74. Xiaoqing Hao, Xiaoxuan Tan, Xinyi Feng, Jing Li, Changhu Xue.  (2026)  Interaction of astaxanthin with bovine serum albumin: Role of aggregation state.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:] [10.1016/j.saa.2026.127656]

75. Xiumin Zhang, Dian Yu, Hongshan Shen, Wei Gao, Huihui Wang, Xunyu Song, Yuxiao Wang, Yukun Song, Mingqian Tan.  (2026)  Size-controlled and antioxidant proanthocyanidin nanoparticle-stabilized high internal phase Pickering emulsions for astaxanthin delivery.  FOOD CHEMISTRY,      [PMID:] [10.1016/j.foodchem.2026.148801]