Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the therapy of cardiovascular diseases.
| Sonrisas canónicas | CC1(C(CCC23C1C(CC4C2(C3)CCC5(C4(CC(C5C6(CCC(O6)C(C)(C)O)C)O)C)C)OC7C(C(C(C(O7)CO)O)O)O)OC8C(C(C(CO8)O)O)O)C |
|---|---|
| IUPAC Name | (2R,3R,4S,5S,6R)-2-[[(1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-14-hydroxy-15-[(2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7,7,12,16-tetramethyl-6-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxy-9-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol |
| InChIKey | QMNWISYXSJWHRY-AUJDEUPOSA-N |
| INCHI | 1S/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24-,25+,26-,27+,28-,29+,30+,31-,32-,33-,34+,37+,38-,39-,40-,41+/m0/s1 |
| Isómeros SMILES | C[C@]12CC[C@@]34C[C@@]35CC[C@@H](C([C@@H]5[C@H](C[C@H]4[C@@]1(C[C@@H]([C@@H]2[C@@]6(CC[C@@H](O6)C(C)(C)O)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)(C)C)O[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O |
| Peso molecular | 784.98 |
| Reaxy-Rn | 57087797 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=57087797&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Lipids and lipid-like molecules |
| Clase | Steroids and steroid derivatives |
| Subclass | Steroidal glycosides |
| Intermediate Tree Nodes | Steroidal saponins |
| Direct Parent | Cucurbitacin glycosides |
| Alternative Parents | Triterpene saponins Triterpenoids Cycloartanols and derivatives 16-beta-hydroxysteroids O-glycosyl compounds Oxanes Monosaccharides Tetrahydrofurans Tertiary alcohols Secondary alcohols Cyclic alcohols and derivatives Acetals Polyols Dialkyl ethers Oxacyclic compounds Primary alcohols Hydrocarbon derivatives |
| Molecular Framework | Aliphatic heteropolycyclic compounds |
| Substituents | Cucurbitacin glycoside skeleton - Triterpene saponin - Triterpene glycoside - Cycloartanol-skeleton - 9b,19-cyclo-lanostane-skeleton - Cycloartane-skeleton - Triterpenoid - 16-hydroxysteroid - 16-beta-hydroxysteroid - Hydroxysteroid - Glycosyl compound - O-glycosyl compound - Oxane - Monosaccharide - Tetrahydrofuran - Tertiary alcohol - Cyclic alcohol - Secondary alcohol - Organoheterocyclic compound - Oxacycle - Acetal - Dialkyl ether - Ether - Polyol - Alcohol - Organic oxygen compound - Primary alcohol - Hydrocarbon derivative - Organooxygen compound - Aliphatic heteropolycyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as cucurbitacin glycosides. These are polycyclic compounds containing a carbohydrate derivative glycosidically linked to a curcubitane nucleus. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 E2422008 | Certificate of Analysis | Apr 29, 2026 | A426153 |
| Peso molecular | 785.000 g/mol |
|---|---|
| XLogP3 | 1.300 |
| Hydrogen Bond Donor Count | 9 |
| Hydrogen Bond Acceptor Count | 14 |
| Rotatable Bond Count | 7 |
| Exact Mass | 784.461 Da |
| Monoisotopic Mass | 784.461 Da |
| Topological Polar Surface Area | 228.000 Ų |
| Heavy Atom Count | 55 |
| Formal Charge | 0 |
| Complexity | 1460.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 21 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Xiulian Zhang, Xueliang Li, Wei Ma, Fangying Liu, Pinxian Huang, Lei Wei, Li Li, Yechang Qian. (2023) Astragaloside IV restores Th17/Treg balance via inhibiting CXCR4 to improve chronic obstructive pulmonary disease. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, [PMID:37417915] [10.1080/08923973.2023.2228479] |
| 2. Huaxian Chen, Xingyang Wan, Qiulan He, Guozhong Xiao, Yihui Zheng, Minyi Luo, Chaoxin Yang, Donglin Ren, Li Lu, Hui Peng, Hongcheng Lin. (2024) Single-cell RNA sequencing reveals cellular dynamics and therapeutic effects of astragaloside IV in slow transit constipation. Biomolecules and Biomedicine, [PMID:38289380] [10.17305/bb.2024.10187] |
| 3. Qifang Wu, Yingna Li, Yunyun Zhao, Ruifen Zhang, Jingyang Tong, Chunlei Ji, Yiming Zhao, Mingjiang Wu, Xiaosheng Jin, Dandan Wang, Haibin Tong, Liwei Sun, Fangbing Liu. (2025) Astragaloside IV Alleviates Fructose-Induced Intestinal Metabolic Senescence by Targeting Ketohexokinase Asn261/Ala226 to Preserve Intestinal Stem Cell Homeostasis. ACS Central Science, [PMID:41019116] [10.1021/acscentsci.5c00726] |
| 4. Lanxi Xu, Yan Feng, Xintian Zheng, Meiyu Wang, Yan Fang, Lin Li, Jiadong Xu, Yani Zhang, Weiru Jiang, Lisheng Chu. (2025) Astragaloside IV-preconditioned neural stem cell transplantation promotes neurogenesis and functional recovery via the miR-199a-5p/Caveolin-1 pathway in a rat model of ischemic stroke. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:41275829] [10.1016/j.intimp.2025.115898] |
| 5. Hui Meng Law, Alieta Eyles, Dugald C. Close. (2025) Effects of pruning with flower removal on the growth, starch reserves and secondary metabolites of a medicinal herb, Astragalus mongholicus. SOUTH AFRICAN JOURNAL OF BOTANY, [PMID:] [10.1016/j.sajb.2025.11.041] |
