Atglistatina - ≥98% , CAS No.1469924-27-3

CAS: 1469924-27-3 Cat. No.: A302918 Peso molecular: 283.37 Número EC: 809-205-7

GRADE & PURITY ≥98%

Synonyms

AKOS026750242 | HY-15859 | FT-0700208 | SW220102-1 | AC-35213 | EN300-172737 | 3-(4'-(dimetilamino)bifenil-3-il)-1,1-dimetilurea | s7364 | AWOPBSAJHCUSAS-UHFFFAOYSA-N | NCGC00261484-01 | 1-[4'-(DIMETILAMINO)-[1,1'-BIFENIL]-3-YL]-3,3-DIMETILUREA | 3-

Storage

Conservar a -20°C

Shipped In

Hielera + almohadillas de hielo

Specifications

Sinónimos

AKOS026750242 | HY-15859 | FT-0700208 | SW220102-1 | AC-35213 | EN300-172737 | 3-(4'-(dimetilamino)bifenil-3-il)-1, 1-dimetilurea | s7364 | AWOPBSAJHCUSAS-UHFFFAOYSA-N | NCGC00261484-01 | 1-[4'-(DIMETILAMINO)-[1, 1'-BIFENIL]-3-YL]-3, 3-DIMETILUREA | 3-

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

La atglistatina es el primer fármaco que inhibe selectivamente la adipotriglicérido lipasa (ATGL), una enzima limitante de la velocidad de movilización de los ácidos grasos de las reservas celulares de triglicéridos. La IC50 de la atglistatina fue de 0, 7

Condiciones de almacenamiento de almacenamiento

Conservar a -20°C

Enviado en

Hielera + almohadillas de hielo

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 504772197
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504772197
• Sonrisas canónicas: CN(C)C1=CC=C(C=C1)C2=CC(=CC=C2)NC(=O)N(C)C
• IUPAC Name: 3-[3-[4-(dimethylamino)phenyl]phenyl]-1,1-dimethylurea
• InChIKey: AWOPBSAJHCUSAS-UHFFFAOYSA-N
• INCHI: 1S/C17H21N3O/c1-19(2)16-10-8-13(9-11-16)14-6-5-7-15(12-14)18-17(21)20(3)4/h5-12H,1-4H3,(H,18,21)
• Isómeros SMILES: CN(C)C1=CC=C(C=C1)C2=CC(=CC=C2)NC(=O)N(C)C
• Peso molecular: 283.37
• Reaxy-Rn: 29267490
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29267490&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Clase Benzene and substituted derivatives
      • Subclass Biphenyls and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Clase: Benzene and substituted derivatives
• Subclass: Biphenyls and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Biphenyls and derivatives
• Alternative Parents: N-phenylureas Dialkylarylamines Aniline and substituted anilines Ureas Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Biphenyl - N-phenylurea - Tertiary aliphatic/aromatic amine - Dialkylarylamine - Aniline or substituted anilines - Tertiary amine - Urea - Amine - Organic oxide - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Hydrocarbon derivative - Aromatic homomonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

PNPLA2 Tchem Patatin-like phospholipase domain-containing protein 2 (1 Activities)

Discover Target: PNPLA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Objetivos asociados (no humanos)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pnpla2 Patatin-like phospholipase domain-containing protein 2 (302 Activities)

Discover Target: Pnpla2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMSO: 20 mg/mL, clear
• Peso molecular: 283.370 g/mol
• XLogP3: 3.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 283.168 Da
• Monoisotopic Mass: 283.168 Da
• Topological Polar Surface Area: 35.600 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 335.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Jian Chen, Zhixiang Wei, Zixuan Song, Sitong Meng, Jiaqi An, Zhenqun Zhang, Yaning Biao, Muqing Zhang, Yixin Zhang.  (2026)  Atractylodin ameliorates obesity-associated hepatic steatosis by regulating the PLIN2-ATGL/CPT1A axis-mediated lipid droplet-mitochondria interactions.  PHYTOMEDICINE,      [PMID:] [10.1016/j.phymed.2026.158134]