≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
🌡
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
📋
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
📚
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
AZ12672857 is an orally active inhibitor of EphB4 ( IC 50 =1.3 nM) and Src kinases . AZ12672857 shows good inhibition of proliferation of c-Src transfected 3T3 cells (IC 50 =2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC 50 =9 nM)
In Vitro
AZ12672857 shows only modest inhibition of CYP P450 (IC 50 =5 μM against 2C9 and 3A4, >10 μM against 1A4, 2D6 and 2C19). AZ12672857 inhibits p-KDR in HUVEC with an IC 50 of 240 nM and inhibits p-PDGFR-βin MG63 cell line with an IC 50 of 58 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:Src
Specifications
Especificaciones y pureza
≥98%
Mecanismos bioquímicos y fisiológicos
AZ12672857 is an orally active inhibitor of EphB4 ( IC 50 =1.3 nM) and Src kinases . AZ12672857 shows good inhibition of proliferation of c-Src transfected 3T3 cells (IC 50 =2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC 50
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
This compound belongs to the class of organic compounds known as phenylmorpholines. These are aromatic compounds containing a morpholine ring and a benzene ring linked to each other through a CC or a CN bond.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
We use cookies to ensure the website functions properly and, where permitted, to improve your experience. You can manage your preferences at any time in Settings. Learn more in our Cookie Policy.
Shall we send you a message when we have discounts available?
Remind me later
Thank you! Please check your email inbox to confirm.
Products are supplied to verified businesses, institutions, and qualified professionals for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
