Azithromycin Dihydrate - 10mM in DMSO , CAS No.117772-70-0

CAS: 117772-70-0 Cat. No.: A420787 Peso molecular: 785.02 Número EC: 641-134-5

GRADE & PURITY 10mM in DMSO

Synonyms

AZITHROMYCIN DIHYDRATE|117772-70-0|Ribotrex|Zenstavion|Azadose|Azatek|Azitro|Ultreon|Vinzam|Odaz|Toraseptol|Azithromycin (hydrate)|Aciphar|Acitrocin|Azidromic|Azitral|Azitrix|Azitrom|Azitrox|Azitroxil|Azimix|Azitrona Klonal|UNII-5FD1131I7S|5FD1131I7S|Azit

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

An azalide antimicrobial agent active in vitro against various pathogens.

Specifications

Sinónimos

AZITHROMYCIN DIHYDRATE | 117772-70-0 | Ribotrex | Zenstavion | Azadose | Azatek | Azitro | Ultreon | Vinzam | Odaz | Toraseptol | Azithromycin (hydrate) | Aciphar | Acitrocin | Azidromic | Azitral | Azitrix | Azitrom | Azitrox | Azitroxil | Azimix | Azitrona Klonal | UNII-5FD1131I7S | 5FD1131I7S | Azit

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Macrolide antibiotic. Bacterial 50S ribosomal inhibitor. Inhibits translation, cell viability and growth rate of bacterial cells (IC 50 = 0.4 μg/ml). Orally active against gram-negative and gram-positive bacteria.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nombres e identificadores

• Sonrisas canónicas: CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O.O.O
• IUPAC Name: (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one;dihydrate
• InChIKey: SRMPHJKQVUDLQE-KUJJYQHYSA-N
• INCHI: 1S/C38H72N2O12.2H2O/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28;;/h20-33,35,41-43,45-46H,15-19H2,1-14H3;2*1H2/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29-,30+,31-,32+,33-,35+,36-,37-,38-;;/m1../s1
• Isómeros SMILES: CC[C@@H]1[C@@]([C@@H]([C@H](N(C[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O.O.O
• WGK Alemania: 3
• RTECS: RN6960000
• Peso molecular: 785.02
• Reaxy-Rn: 24867571
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24867571&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • Clase Organooxygen compounds
      • Subclass Carbohydrates and carbohydrate conjugates
        • Level5 Aminosaccharides
          • Level6 Aminoglycosides

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• Clase: Organooxygen compounds
• Subclass: Carbohydrates and carbohydrate conjugates
• Intermediate Tree Nodes: Aminosaccharides
• Direct Parent: Aminoglycosides
• Alternative Parents: Macrolides and analogues O-glycosyl compounds Oxanes Monosaccharides Tertiary alcohols Trialkylamines Secondary alcohols 1,2-aminoalcohols Amino acids and derivatives Carboxylic acid esters Lactones Polyols Acetals Oxacyclic compounds Azacyclic compounds Monocarboxylic acids and derivatives Dialkyl ethers Carbonyl compounds Hydrocarbon derivatives Organic oxides Organopnictogen compounds
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Aminoglycoside core - Macrolide - Glycosyl compound - O-glycosyl compound - Monosaccharide - Oxane - Tertiary alcohol - 1,2-aminoalcohol - Amino acid or derivatives - Carboxylic acid ester - Lactone - Secondary alcohol - Tertiary amine - Tertiary aliphatic amine - Oxacycle - Acetal - Monocarboxylic acid or derivatives - Organoheterocyclic compound - Polyol - Azacycle - Ether - Dialkyl ether - Carboxylic acid derivative - Organic nitrogen compound - Alcohol - Carbonyl group - Organonitrogen compound - Organopnictogen compound - Amine - Organic oxide - Hydrocarbon derivative - Aliphatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as aminoglycosides. These are molecules or a portion of a molecule composed of amino-modified sugars.
• External Descriptors: hydrate

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Rotación específica [α]: -47° (C=2,EtOH)
• Punto de ebullición (°C): 717℃
• Punto de fusión (°C): 126℃
• Peso molecular: 785.000 g/mol
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 16
• Rotatable Bond Count: 7
• Exact Mass: 784.53 Da
• Monoisotopic Mass: 784.53 Da
• Topological Polar Surface Area: 182.000 Ų
• Heavy Atom Count: 54
• Formal Charge: 0
• Complexity: 1150.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 18
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

Referencias

1. Jun Yao.  (2023)  A multiple signal amplification photoelectrochemical biosensor based on biotin-avidin system for kanamycin sensing in fish and milk via synergism of g-C3N4 and Ru@SiO2.  ANALYTICA CHIMICA ACTA,      [PMID:38220276] [10.1016/j.aca.2023.342141]

2. Lei Han, Yu Zhu Fan, Min Qing, Shi Gang Liu, Yu Zhu Yang, Nian Bing Li, Hong Qun Luo.  (2020)  Smartphones and Test Paper-Assisted Ratiometric Fluorescent Sensors for Semi-Quantitative and Visual Assay of Tetracycline Based on the Target-Induced Synergistic Effect of Antenna Effect and Inner Filter Effect.  ACS Applied Materials & Interfaces,      [PMID:33003698] [10.1021/acsami.0c15482]

3. Xiaoqi Jiang, Jingcheng Huang, Mengting Li, Linjin Li, Yinuo Chen, Jiangfei Chen, Junlun Zhu, Xuedong Wang, He Mei.  (2025)  A novel reversible-responsive ratiometric fluorometry based on an anthracene-based imidazolium ionic liquid and Eu3+-based lanthanide coordination polymers for selective sensing tetracycline in foods and waters.  FOOD CHEMISTRY,      [PMID:41045862] [10.1016/j.foodchem.2025.146551]