technical grade Technical grade for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Room temperature Ships Normal Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 18 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
| Sonrisas canónicas | CCCCCCCCCCCCN1CCCCCC1=O |
|---|---|
| IUPAC Name | 1-dodecylazepan-2-one |
| InChIKey | AXTGDCSMTYGJND-UHFFFAOYSA-N |
| INCHI | 1S/C18H35NO/c1-2-3-4-5-6-7-8-9-10-13-16-19-17-14-11-12-15-18(19)20/h2-17H2,1H3 |
| Isómeros SMILES | CCCCCCCCCCCCN1CCCCCC1=O |
| RTECS | CM3995000 |
| Peso molecular | 281.48 |
| Reaxy-Rn | 167211 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=167211&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Clase | Lactams |
| Subclass | Caprolactams |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Caprolactams |
| Alternative Parents | Azepanes Tertiary carboxylic acid amides Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aliphatic heteromonocyclic compounds |
| Substituents | Caprolactam - Azepane - Tertiary carboxylic acid amide - Carboxamide group - Azacycle - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aliphatic heteromonocyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as caprolactams. These are cyclic amides of caproic acid. Caproic acid is the carboxylic acid derived from hexane with the general formula C5H11COOH. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 A2605130 | Certificate of Analysis | Apr 29, 2025 | A767487 |
| A2623040 | Certificate of Analysis | Apr 29, 2025 | A767487 |
| D2525115 | Certificate of Analysis | Apr 29, 2025 | A767487 |
| D2525116 | Certificate of Analysis | Apr 29, 2025 | A767487 |
| D2525118 | Certificate of Analysis | Apr 29, 2025 | A767487 |
| D2525119 | Certificate of Analysis | Apr 29, 2025 | A767487 |
| D2525144 | Certificate of Analysis | Apr 29, 2025 | A767487 |
| Índice de refracción | 1.460-1.473 |
|---|---|
| Punto de inflamación (°C) | 165 °C |
| Punto de ebullición (°C) | 160 °C/0.6 mmHg |
| Punto de fusión (°C) | -7°C(lit.) |
| Peso molecular | 281.500 g/mol |
| XLogP3 | 5.900 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 11 |
| Exact Mass | 281.272 Da |
| Monoisotopic Mass | 281.272 Da |
| Topological Polar Surface Area | 20.300 Ų |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 240.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Yi Chen, Yongfang Wang, Shasha Song, Xiaoli Zhang, Lili Wu, Jianbing Wu, Xinyu Li. (2023) Topical Application of Baicalin Combined with Echinacoside Ameliorates Psoriatic Skin Lesions by Suppressing the Inflammation-Related TNF Signaling Pathway and the Angiogenesis-Related VEGF Signaling Pathway. ACS Omega, [PMID:37929119] [10.1021/acsomega.3c04281] |
| 2. Ye Liu, Jiufeng Zhao, Xingrui Mu, Junyu Deng, Xingqian Wu, Wenjie He, Yiqiu Liu, Rifang Gu, Felicity Han, Xuqiang Nie. (2023) Asiaticoside-nitric oxide promoting diabetic wound healing through the miRNA-21-5p/TGF-β1/SMAD7/TIMP3 signaling pathway. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:37783408] [10.1016/j.jep.2023.117266] |
| 3. Nan Longyi, Song Haoyuan, Wang Haijun, Mi Ru, Wang Xiaoxu, Fang Liang. (2023) Design of a tulobuterol patch with improved mechanical properties: effect of transdermal permeation enhancers on the release process of metal ligand-based acrylic pressure-sensitive adhesives. Drug Delivery and Translational Research, [PMID:38082031] [10.1007/s13346-023-01435-3] |
| 4. Liuyu Gong, Mathias Bonmarin, Fabrizio Spano, Ya Shen, Lin Shen, Guocheng Han, Shanshan Wei, Qihan Zhang, Zhencheng Chen, Feijun Zhao. (2023) Integrated Device Based on a Sudomotor Nanomaterial for Sweat Detection. ACS Applied Materials & Interfaces, [PMID:37318096] [10.1021/acsami.3c03401] |
| 5. Jiuheng Ruan, Chao Liu, Jiaqi Wang, Ting Zhong, Peng Quan, Liang Fang. (2022) Efficacy and safety of permeation enhancers: A kinetic evaluation approach and molecular mechanism study in the skin. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:36049584] [10.1016/j.ijpharm.2022.122155] |
| 6. Yi-qiu Liu, Dandan Zhang, Junyu Deng, Ye Liu, Wei Li, Xuqiang Nie. (2022) Preparation and Safety Evaluation of Centella asiatica Total Glycosides Nitric Oxide Gel and Its Therapeutic Effect on Diabetic Cutaneous Ulcers. Evidence-based Complementary and Alternative Medicine, [PMID:35368764] [10.1155/2022/1419146] |
| 7. Ding Zhang, Boqi Chen, Qingke Mu, Wei Wang, Kaili Liang, Liyan Wang, Qing Wang. (2021) Topical delivery of gambogic acid assisted by the combination of low-frequency ultrasound and chemical enhancers for chemotherapy of cutaneous melanoma. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, [PMID:34391880] [10.1016/j.ejps.2021.105975] |
| 8. Ding Zhang, Wei Wang, Tao Hou, Yanjun Pang, Chao Wang, Shuai Wu, Qing Wang. (2020) New Delivery Route of Gambogic Acid Via Skin for Topical Targeted Therapy of Cutaneous Melanoma and Reduction of Systemic Toxicity. JOURNAL OF PHARMACEUTICAL SCIENCES, [PMID:33373608] [10.1016/j.xphs.2020.12.024] |
| 9. Su Yanping, Lu Wenxiang, Fu Xiaoling, Xu Ying, Ye Lixiang, Yang Jian, Huang Huihui, Yu Changxi. (2020) Formulation and Pharmacokinetic Evaluation of a Drug-in-Adhesive Patch for Transdermal Delivery of Koumine. AAPS PHARMSCITECH, 21 (8): (1-11). [PMID:33099696] [10.1208/s12249-020-01793-y] |
| 10. Dong Jiang, Huajin Tan, Rujiao Zhang, Kaikang Wang, Yujia Zhang, Xiaochuan Tan, Wensheng Zheng. (2020) Borneol-mediated vardenafil hydrochloride patch for pediatric pulmonary arterial hypertension: Preparation, characterization and in vivo study. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:32991961] [10.1016/j.ijpharm.2020.119864] |
| 11. Wei Wang, Chao Liu, Zheng Luo, Xiaocao Wan, Liang Fang. (2018) Investigation of molecular mobility of pressure-sensitive-adhesive in oxybutynin patch in vitro and in vivo: Effect of sorbitan monooleate on drug release and patch mechanical property. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, [PMID:29928984] [10.1016/j.ejps.2018.06.016] |
| 12. Ning Li, Peng Quan, XiaoCao Wan, Chao Liu, Xiaochang Liu, Liang Fang. (2017) Mechanistic insights of the enhancement effect of sorbitan monooleate on olanzapine transdermal patch both in release and percutaneous absorption processes. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, [PMID:28693956] [10.1016/j.ejps.2017.07.006] |
| 13. Zhao Qingliang, Dai Cuixia, Fan Shanhui, Lv Jing, Nie Liming. (2016) Synergistic efficacy of salicylic acid with a penetration enhancer on human skin monitored by OCT and diffuse reflectance spectroscopy. Scientific Reports, 6 (1): (1-11). [PMID:27721398] [10.1038/srep34954] |
| 14. Mu Xingrui, Chen Jitao, Zhu Huan, Deng Junyu, Wu Xingqian, He Wenjie, Ye Penghui, Gu Rifang, Wu Youzhi, Han Felicity, Nie Xuqiang. (2025) Asiaticoside-nitric oxide synergistically accelerate diabetic wound healing by regulating key metabolites and SRC/STAT3 signaling. Burns & Trauma, [PMID:40066291] [10.1093/burnst/tkaf009] |
| 15. Peng Sun, Hui Li, Kaihua Gong, Yang Zhang, Yu Cai, Chao Liu, Liang Fang. (2024) Deep eutectic solvent combined with permeation enhancer strategy to convert tandospirone from oral to transdermal formulations improving drug bioavailability. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, [PMID:39490429] [10.1016/j.ejpb.2024.114570] |
| 16. Yi Chen, Shasha Song, Yongfang Wang, Xiaoli Zhang, Jiafen Zhang, Lili Wu, Jianbing Wu, Xinyu Li. (2024) Topical application of berberine ameliorates imiquimod-induced psoriasis-like dermatitis in BALB/c mice via suppressing JAK1/STAT1 signaling pathway. Arabian Journal of Chemistry, [PMID:] [10.1016/j.arabjc.2024.105612] |
| 17. Yi Chen, Shasha Song, Yongfang Wang, Lili Wu, Jianbing Wu, Zhengmeng Jiang, Xinyu Li. (2024) Topical application of magnolol ameliorates psoriasis-like dermatitis by inhibiting NLRP3/Caspase-1 pathway and regulating tryptophan metabolism. BIOORGANIC CHEMISTRY, [PMID:39693920] [10.1016/j.bioorg.2024.108059] |
| 18. Jie Wang, Xuemei Gu, Xia Gao, Huifang Gao, Jing Chen, Zhiyang Lv, Lei Chen, Yunzhu Xu, Xialin Chen, Liang Cao, Zhenzhong Wang, Jinzhou Tian, Wei Xiao. (2025) Preparation and evaluation of gastrodin-ferulic acid co-loaded liposome gel patches for the treatment of migraine. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, [PMID:40439436] [10.1080/03639045.2025.2513408] |
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