10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 5 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Aztreonam (SQ 26776) is a synthetic monocyclic beta-lactamantibiotic, used to treat Gram-negative aerobic bacteria infection.
In vitro
Aztreonam causes significant suppression of human colony forming unit-erythroid (cfu-e), burst forming unit-erythroid (bfu-e) and colony forming unit-granulocyte macrophage (cfu-gm) at both peak and trough serum concentrations in human bone marrow cells. Aztreonam is hydrolyzed at measurable rates by class A beta-lactamases, a TEM-2 type penicillinase and the Proteus vulgaris cephalosporinase with a broad substraterange. Aztreonam is extremely stable as to the typical class C cephalosporinase of Citrobacter freundii, and acts as a competitive and progressive inhibitor for the beta-lactamase. Aztreonam (AZT) combined with clindamycin (CLDM) has synergistic effects on Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, and Haemophilus influenzae, which are sensitive or quasi-sensitive to CLDM, in the presence of CLDM at MIC or sub-MIC. Aztreonam reduces the cfu of some strains by 1 log unit without preserving the integrity of cystic fibrosis airway cell monolayers, while decreasing the biofilms of other clinical isolates by 4 log units and protecting the monolayers from being compromised.
In vivo
Aztreonam (300 mg/kg) results in a significant decrease in the content of hepatic microsomal P450, while no significant change is observed in hepatic cytochrome b5 content and NADPH-cytochrome c (P450) reductase activity.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥98%
| Isómeros SMILES | C[C@H]1[C@@H](C(=O)N1S(=O)(=O)O)NC(=O)/C(=N\OC(C)(C)C(=O)O)/C2=CSC(=N2)N |
|---|---|
| WGK Alemania | 2 |
| RTECS | UA2451400 |
| Peso molecular | 435.43 |
| Reaxy-Rn | 30652625 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=30652625&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Rotación específica [α] | -28° (C=0.5,H2O) |
|---|---|
| Punto de fusión (°C) | 227°C(dec.)(lit.) |
| 1. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723] [10.1016/j.mcpro.2022.100248] |
| 2. Shuting Xie, Ri He, Qifan Zhu, Mingliang Jin, Ruizhi Yang, Shitao Shen, Jiayi Cui, Yiying Zou, Minmin Zhang, Lingling Shui. (2022) Label-free optical sensor based on liquid crystal sessile droplet array for penicillin G determination. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, [PMID:] [10.1016/j.colsurfa.2022.128728] |
| 3. Xicheng Xie, Lingyun Li, Lumei Wang, Chaoqiang Pan, Dongwei Zhang, Guoqing Shen, Xicheng Xie, Lingyun Li, Lumei Wang, Chaoqiang Pan, Dongwei Zhang, Guoqing Shen. (2021) Colourimetric Detection of Tebuconazole in Aqueous Solution Based on an Unmodified Aptamer and the Aggregation of Gold Nanoparticles. AUSTRALIAN JOURNAL OF CHEMISTRY, 74 (12): (838-846). [PMID:] [10.1071/CH21171] |
| 4. Pengcheng Xing, Di Wu, Jingshuai Chen, Jiming Song, Changjie Mao, Yuanhao Gao, Helin Niu. (2019) A Cd-MOF as a fluorescent probe for highly selective, sensitive and stable detection of antibiotics in water. ANALYST, 144 (8): (2656-2661). [PMID:30843538] [10.1039/C8AN02442A] |
| 5. Wenyuan Zhou, Xinhui Li, Lei Shi, Hua H. Wang, He Yan. (2018) Novel SCCmec type XII methicillin-resistant Staphylococcus aureus isolates identified from a swine production and processing chain. VETERINARY MICROBIOLOGY, [PMID:30322521] [10.1016/j.vetmic.2018.09.007] |
| 6. Ai Guo, Dianbao Zuo, Li Shi, Ming Guo, Jinquan Li, Caili Li, Puqing Wang, Xiaodong Sun, Ming Sang. (2025) Identification and preclinical efficacy evaluation of two lytic bacteriophages targeting highly virulent and multidrug-resistant Klebsiella pneumoniae. Annals of Clinical Microbiology and Antimicrobials, [PMID:40835923] [10.1186/s12941-025-00812-9] |
| 7. Jiansheng Lin, Chunyan Lin, Jingyang Zheng. (2025) LysR-type transcriptional regulator CARR represses the expression of blaCAR-2 and reduces P. diazotrophicus resistance to cefalothin, cefuroxime and cefotaxime. Frontiers in Cellular and Infection Microbiology, [PMID:40959139] [10.3389/fcimb.2025.1616646] |
