Azvudine - ≥98% , Human immunodeficiency virus type 1 reverse transcriptase inhibitor, CAS No.1011529-10-4, Human immunodeficiency virus type 1 reverse transcriptase inhibitor

CAS: 1011529-10-4 Cat. No.: A648672 Fórmula: C₉H₁₁FN₆O₄ Peso molecular: 286.22 PubChem CID: 24769759

CALIDAD & PUREZA ≥98%

Synonyms

RO-0622 | F86375 | 1011529-10-4 | 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinocytidine | 4-amino-1-[(2R,3S,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one | Azvudine | FNCRO-0622 | A848947 | DTXSID901027757 | AKOS040741284 |

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Azvudine (FNC) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral strains.

Especificaciones

Sinónimos

RO-0622 | F86375 | 1011529-10-4 | 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinocytidine | 4-amino-1-[(2R,3S,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one | Azvudine | FNCRO-0622 | A848947 | DTXSID901027757 | AKOS040741284 |

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

Azvudine (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV , HBV and HCV . Azvudine exerts highly potent inhibition on HIV-1 (EC 50 s ranging from 0.03 to 6.92 nM) and HIV-2 (EC 50 s ranging from 0.018

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Mecanismo de acción

Human immunodeficiency virus type 1 reverse transcriptase inhibitor

Pureza

≥98%

Propiedades del producto

ALogP

-0.8

Nombres e identificadores

Pubchem Sid

528763354

Sonrisas canónicas

C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)F

IUPAC Name

4-amino-1-[(2R,3S,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

InChIKey

KTOLOIKYVCHRJW-XZMZPDFPSA-N

INCHI

1S/C9H11FN6O4/c10-5-6(18)9(3-17,14-15-12)20-7(5)16-2-1-4(11)13-8(16)19/h1-2,5-7,17-18H,3H2,(H2,11,13,19)/t5-,6-,7+,9+/m0/s1

Isómeros SMILES

C1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@](O2)(CO)N=[N+]=[N-])O)F

CAS alternativo

1011529-10-4

PubChem CID

24769759

Términos de entrada MeSH

2'-deoxy-2'-beta-fluoro-4'-azidocytidine;4'-azido-2'-deoxy-2'-fluorocytidine;4-amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-5-((imino-l,5-azanylidene)amino)tetrahydrofuran-2-yl)pyrimidin-2-one;4-amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(

Peso molecular

286.22

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Diazines
      • Subclass Pyrimidines and pyrimidine derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Diazines
• Subclass: Pyrimidines and pyrimidine derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyrimidones
• Alternative Parents: Aminopyrimidines and derivatives Primary aromatic amines Hydropyrimidines Imidolactams Oxolanes Heteroaromatic compounds Secondary alcohols Azo compounds Azo imides Fluorohydrins Azacyclic compounds Oxacyclic compounds Hydrocarbon derivatives Organic zwitterions Organofluorides Organopnictogen compounds Primary alcohols Alkyl fluorides Organic salts Organic oxides
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Aminopyrimidine - Pyrimidone - Hydropyrimidine - Imidolactam - Primary aromatic amine - Heteroaromatic compound - Oxolane - Azo compound - Azo imide - Fluorohydrin - Halohydrin - Secondary alcohol - Oxacycle - Azacycle - Organic zwitterion - Primary amine - Primary alcohol - Alkyl fluoride - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Alcohol - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Amine - Alkyl halide - Organic salt - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as pyrimidones. These are compounds that contain a pyrimidine ring, which bears a ketone. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

Homo sapiens (32628 Activities)

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MT2 (2907 Activities)

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MT4 (17854 Activities)

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HEK293 (82097 Activities)

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Objetivos asociados (no humanos)

Rattus norvegicus (775804 Activities)

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Hepatitis B virus (7925 Activities)

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Human immunodeficiency virus 1 (70413 Activities)

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Hepatitis C virus (23859 Activities)

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SARS-CoV-2 (38078 Activities)

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Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMSO : 125 mg/mL (436.73 mM; Need ultrasonic)
• Peso molecular: 286.220 g/mol
• XLogP3: -0.800
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 286.083 Da
• Monoisotopic Mass: 286.083 Da
• Topological Polar Surface Area: 123.000 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 533.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 1
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1