Bafilomycin C1 - ≥98% , CAS No.88979-61-7

CAS: 88979-61-7 Cat. No.: B275381 Peso molecular: 720.89

GRADE & PURITY ≥98%

Synonyms

(E)-4-[(2R,4R,5S,6R)-2-hydroxy-2-[(2S,3R,4S)-3-hydroxy-4-[(3S,4Z,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-5-methyl-6-propan-2-yloxan-4-yl]oxy-4-oxobut-2-enoic acid

Storage

Protected from light,Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Descripción general

Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H+-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi. Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC).

Specifications

Sinónimos

(E)-4-[(2R, 4R, 5S, 6R)-2-hydroxy-2-[(2S, 3R, 4S)-3-hydroxy-4-[(3S, 4Z, 6E, 9S, 10S, 11R, 12E, 14Z)-10-hydroxy-3, 15-dimethoxy-7, 9, 11, 13-tetramethyl-16-oxo-1-oxacyclohexadeca-4, 6, 12, 14-tetraen-2-yl]pentan-2-yl]-5-methyl-6-propan-2-yloxan-4-yl]oxy-4-oxobut-2-enoic acid

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

Selective vacuolar-type H + -ATPase inhibitor. Na + , K + -ATPase inhibitor. Macrolide antibiotic agent. Shows bacteriostatic effects against Gram-positive bacteria. Shows antifungal effects.

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Desiccated

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)OC(=O)C=CC(=O)O)O)O)OC)C
• IUPAC Name: (E)-4-[2-hydroxy-2-[3-hydroxy-4-[(4E,6E,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-5-methyl-6-propan-2-yloxan-4-yl]oxy-4-oxobut-2-enoic acid
• InChIKey: WUDBXVQNMOTFEE-FUGNQFJWSA-N
• INCHI: 1S/C39H60O12/c1-21(2)36-26(7)31(49-33(42)16-15-32(40)41)20-39(46,51-36)28(9)35(44)27(8)37-29(47-10)14-12-13-22(3)17-24(5)34(43)25(6)18-23(4)19-30(48-11)38(45)50-37/h12-16,18-19,21,24-29,31,34-37,43-44,46H,17,20H2,1-11H3,(H,40,41)/b14-12+,16-15+,22-13+,23-18+,30-19-
• Isómeros SMILES: CC1C/C(=C/C=C/C(C(OC(=O)/C(=C/C(=C/C(C1O)C)/C)/OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)OC(=O)/C=C/C(=O)O)O)O)OC)/C
• Peso molecular: 720.89
• Reaxy-Rn: 4632457
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4632457&ln=

Propiedades químicas y físicas

• Solubilidad: Soluble in ethanol and in DMSO
• Sensibilidad: Moisture sensitive;light sensitive