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BAY-0069 - ≥98% , CAS No.420826-65-9
Disponible para pedir
GRADE & PURITY ≥98%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
BAY-0069 is a potent and selective PPARγ inverse agonist with an IC 50 value of 6.3 nM and 24 nM for human PPARγ and mouse PPARγ . BAY-0069 can be used to research cancer
In Vitro
BAY-0069 inhibits CYP2C8 with an IC 50 of 4.3 μM. BAY-0069 (0.1 nM-1 μM; 7 days) leads to antiproliferative effects in the PPARγ-amplified cell line UM-UC-9. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: PPARγ-amplified cell line UM-UC-9 Concentration: 0.0001, 0.001, 0.01, 0.01 and 1 μM Incubation Time: 7 days Result: Inhibited PPARγ-amplified cell line UM-UC-9 with an IC 50 of 2.54 nM.
In Vivo
BAY-0069 (1 μM; 1 h) exhibits excellent microsomal stability with CL b,hmic of 0.47 L/h/kg in human liver microsomes and CL b,rhep of 3.9 L/h/kg in rat liver hepatocytes . Pharmacokinetic Parameters of BAY-0069 in female NMRI nu/nu mice . Route P.O. (100 mg/kg) I.P. S.C. AUC 0-tlast (mg/L·h) 0.074 0.26 0.045 C max (nM) 35 59 4.4 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:hPPARγ 6.3 nM (IC 50 ) mouse PPARγ 24 nM (IC 50 )
Specifications
Especificaciones y pureza
≥98%
Mecanismos bioquímicos y fisiológicos
BAY-0069 is a potent and selective PPARγ inverse agonist with an IC 50 value of 6.3 nM and 24 nM for human PPARγ and mouse PPARγ . BAY-0069 can be used to research cancer.
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Tipo de acción
ANTAGONIST
Pureza
≥98%
Nombres e identificadores
| Peso molecular | 466.28 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
| Solubilidad | DMSO : 100 mg/mL (214.46 mM; ultrasonic and warming and heat to 60°C) |
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Calculadoras de soluciones
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