Berberine - Moligand™, ≥99% , Inhibitor of CYP2D6, CAS No.2086-83-1, Inhibitor of CYP2D6

CAS: 2086-83-1 Cat. No.: B414323 Peso molecular: 336.37 Número EC: 218-229-1
Disponible para pedir
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
Synonyms
AKOS002141363 | BERBERINE [VANDF] | CCG-35898 | KBio2_006726 | GNF-PF-4545 | 9,10-DIMETHOXY-5,6-DIHYDRO(1,3)DIOXOLO(4,5-G)ISOQUINO(3,2-A)ISOQUINOLIN-7-IUM | CHEBI:16118 | BSPBio_002156 | cid_12456 | SBI-0051613.P002 | NSC646666 | CAS-633-65-8 | ACon1_0019
Storage
Protected from light,Store at -20°C
Shipped In
Ice chest + Ice pads
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
50mg
B414323-50mg
3
9,90US$
250mg
B414323-250mg
1
25,90US$
1g
B414323-1g
3
46,90US$
5g
B414323-5g
2
129,90US$
Enter a quantity for the sizes you want to add.
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Why this grade

Moligand™, ≥99% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Protected from light,Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 79 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Product Describtion:

Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties.

Specifications

Sinónimos
AKOS002141363 | BERBERINE [VANDF] | CCG-35898 | KBio2_006726 | GNF-PF-4545 | 9, 10-DIMETHOXY-5, 6-DIHYDRO(1, 3)DIOXOLO(4, 5-G)ISOQUINO(3, 2-A)ISOQUINOLIN-7-IUM | CHEBI:16118 | BSPBio_002156 | cid_12456 | SBI-0051613.P002 | NSC646666 | CAS-633-65-8 | ACon1_0019
Especificaciones y pureza
Moligand™, ≥99%
Mecanismos bioquímicos y fisiológicos
Berberine (Umbellatine), an alkaloid isolated from Rhizoma coptidis, has broad applications, particularly as an antibacterial agent in the clinic.
Condiciones de almacenamiento de almacenamiento
Protected from light, Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Tipo de acción
INHIBITOR
Mecanismo de acción
Inhibitor of CYP2D6
Pureza
≥99%
Nombres e identificadores
Pubchem Sid488179694
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488179694
Sonrisas canónicasCOC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC
IUPAC Name16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene
InChIKeyYBHILYKTIRIUTE-UHFFFAOYSA-N
INCHI1S/C20H18NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-10H,5-6,11H2,1-2H3/q+1
Isómeros SMILES COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC
CAS alternativo 2086-83-1
Términos de entrada MeSH Berberine;Umbellatine
Peso molecular 336.37
Reaxy-Rn 3570374
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3570374&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassAlkaloids and derivatives
ClaseProtoberberine alkaloids and derivatives
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentProtoberberine alkaloids and derivatives
Alternative Parents Isoquinolines and derivatives  Benzodioxoles  Anisoles  Alkyl aryl ethers  Pyridinium derivatives  Heteroaromatic compounds  Oxacyclic compounds  Azacyclic compounds  Acetals  Organopnictogen compounds  Organonitrogen compounds  Hydrocarbon derivatives  Organic cations  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Protoberberine skeleton - Isoquinoline - Benzodioxole - Anisole - Alkyl aryl ether - Pyridine - Pyridinium - Benzenoid - Heteroaromatic compound - Acetal - Ether - Oxacycle - Azacycle - Organoheterocyclic compound - Organonitrogen compound - Hydrocarbon derivative - Organic nitrogen compound - Organooxygen compound - Organic oxygen compound - Organopnictogen compound - Organic cation - Aromatic heteropolycyclic compound
DescripciónThis compound belongs to the class of organic compounds known as protoberberine alkaloids and derivatives. These are alkaloids with a structure based on a protoberberine moiety, which consists of a 5,6-dihydrodibenzene moiety fused to a quinolizinium and forming 5,6-Dihydrodibenzo(a,g)quinolizinium skeleton.
External Descriptors a small molecule
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
CYP1B1 Tchem Cytochrome P450 1B1 (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2D6 Tclin Cytochrome P450 2D6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ACHE Tclin Acetylcholinesterase (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

53 results found

Lot NumberCertificate TypeFechaArticulo
H2302335Certificate of AnalysisMay 11, 2026 B414323
H2302342Certificate of AnalysisMay 11, 2026 B414323
H2302343Certificate of AnalysisMay 11, 2026 B414323
H2302548Certificate of AnalysisMay 11, 2026 B414323
J2527492Certificate of AnalysisOct 15, 2025 B414323
J2527487Certificate of AnalysisOct 15, 2025 B414323
J2527488Certificate of AnalysisOct 15, 2025 B414323
J2527490Certificate of AnalysisOct 15, 2025 B414323
G2523205Certificate of AnalysisJul 14, 2025 B414323
G2523206Certificate of AnalysisJul 14, 2025 B414323
G2523207Certificate of AnalysisJul 14, 2025 B414323
G2523208Certificate of AnalysisJul 14, 2025 B414323
D2524164Certificate of AnalysisApr 12, 2025 B414323
G2512003Certificate of AnalysisApr 12, 2025 B414323
G2516009Certificate of AnalysisApr 12, 2025 B414323
D2524167Certificate of AnalysisApr 12, 2025 B414323
D2524166Certificate of AnalysisApr 12, 2025 B414323
D2524165Certificate of AnalysisApr 12, 2025 B414323
A2503051Certificate of AnalysisDec 20, 2024 B414323
A2503050Certificate of AnalysisDec 20, 2024 B414323
A2503049Certificate of AnalysisDec 20, 2024 B414323
A2503048Certificate of AnalysisDec 20, 2024 B414323
A2403050Certificate of AnalysisDec 20, 2024 B414323
J2423376Certificate of AnalysisOct 15, 2024 B414323
J2423373Certificate of AnalysisOct 15, 2024 B414323
J2423374Certificate of AnalysisOct 15, 2024 B414323
J2423375Certificate of AnalysisOct 15, 2024 B414323
G2431157Certificate of AnalysisJul 18, 2024 B414323
G2431155Certificate of AnalysisJul 18, 2024 B414323
G2431156Certificate of AnalysisJul 18, 2024 B414323
E2406339Certificate of AnalysisApr 22, 2024 B414323
E2406338Certificate of AnalysisApr 22, 2024 B414323
E2406337Certificate of AnalysisApr 22, 2024 B414323
C2408204Certificate of AnalysisFeb 04, 2024 B414323
C2408208Certificate of AnalysisFeb 04, 2024 B414323
C2408205Certificate of AnalysisFeb 04, 2024 B414323
A2403192Certificate of AnalysisDec 15, 2023 B414323
A2403193Certificate of AnalysisDec 15, 2023 B414323
A2403194Certificate of AnalysisDec 15, 2023 B414323
A2403195Certificate of AnalysisDec 15, 2023 B414323
A2403196Certificate of AnalysisDec 15, 2023 B414323
A2403197Certificate of AnalysisDec 15, 2023 B414323
A2403198Certificate of AnalysisDec 15, 2023 B414323
A2403199Certificate of AnalysisDec 15, 2023 B414323
H2302339Certificate of AnalysisJul 12, 2023 B414323
H2302337Certificate of AnalysisJul 12, 2023 B414323
H2302336Certificate of AnalysisJul 12, 2023 B414323
H2302332Certificate of AnalysisJul 12, 2023 B414323
H2223360Certificate of AnalysisJul 19, 2022 B414323
H2223215Certificate of AnalysisJul 19, 2022 B414323
H2223214Certificate of AnalysisJul 19, 2022 B414323
H2223213Certificate of AnalysisJul 19, 2022 B414323
F2325072Certificate of AnalysisJul 19, 2022 B414323

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Propiedades químicas y físicas
SolubilidadSolubility (25°C) In vitro DMSO: 22.5 mg/mL (66.89 mM); Ethanol: 5 mg/mL (14.86 mM); Water: 1 mg/mL (2.97 mM);
SensibilidadMoisture Sensitive;Light Sensitive
Peso molecular336.400 g/mol
XLogP33.600
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass336.124 Da
Monoisotopic Mass336.124 Da
Topological Polar Surface Area40.800 Ų
Heavy Atom Count25
Formal Charge1
Complexity488.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Preguntas frecuentes y artículos
Citations of This Product
Referencias
1. Jin Pian, Zhu Fucheng, Zhou Wen, Liu Chen, Li Na, Liu Houmei.  (2023)  Developing magnetic functionalized dendritic fibrous mesoporous silica as advanced adsorbent for quaternary ammonium alkaloids.  MICROCHIMICA ACTA,  190  (12): (1-12).  [PMID:37999777] [10.1007/s00604-023-06053-x]
2. Changsheng Zhong, Yilin Xie, Huifang Wang, Wenxian Chen, Zhenbo Yang, Lei Zhang, Qin Deng, Ting Cheng, Mengyang Li, Jin Ju, Yanyan Liu, Haihai Liang.  (2023)  Berberine inhibits NLRP3 inflammasome activation by regulating mTOR/mtROS axis to alleviate diabetic cardiomyopathy.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:38096968] [10.1016/j.ejphar.2023.176253]
3. Yuting Zhang, Xin Gao, Xiaoning Tang, Lincai Peng, Heng Zhang, Shumei Zhang, Qiuyue Hu, Jiaqi Li.  (2023)  A dual pH- and temperature-responsive hydrogel produced in situ crosslinking of cyclodextrin-cellulose for wound healing.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:37703977] [10.1016/j.ijbiomac.2023.126693]
4. Jihui Lu, Zhijia Wang, Desheng Cai, Xiaoyu Lin, Xuemei Huang, Zhihua Yuan, Yaozhi Zhang, Haimin Lei, Penglong Wang.  (2023)  Carrier-Free Binary Self-Assembled Nanomedicines Originated from Traditional Herb Medicine with Multifunction to Accelerate MRSA-Infected Wound Healing by Antibacterial, Anti-Inflammation and Promoting Angiogenesis.  International Journal of Nanomedicine,      [PMID:37667771] [10.2147/IJN.S422944]
5. Jiawen Han, Yaru Ding, Xujuan Lv, Yuwei Zhang, Daoqing Fan.  (2023)  Integration of G-Quadruplex and Pyrene as a Simple and Efficient Ratiometric Fluorescent Platform That Programmed by Contrary Logic Pair for Highly Sensitive and Selective Coralyne (COR) Detection.  Biosensors-Basel,  13  (4): (489).  [PMID:37185564] [10.3390/bios13040489]
6. Yun Yang, Yuan Xiong, Guanghao Zhu, Mengru Sun, Kun Zou, Yitian Zhao, Yong Zhang, Zhijian Xu, Yiming Li, Weiliang Zhu, Qi Jia, Bo Li, Guangbo Ge.  (2023)  Discovery of seven-membered ring berberine analogues as highly potent and specific hCES2A inhibitors.  CHEMICO-BIOLOGICAL INTERACTIONS,      [PMID:37080375] [10.1016/j.cbi.2023.110501]
7. Wei Hu, Wei Zhou, Chenlu Wang, Zichun Liu, Zilin Chen.  (2022)  Direct coupling in-tube solid-phase microextraction with mass spectrometry using polymer coated open-tubular column for rapid analysis of antiepileptic drugs in biofluids.  ANALYTICA CHIMICA ACTA,      [PMID:36641145] [10.1016/j.aca.2022.340775]
8. Jingyi Hu, Yiheng Tong, Zhaofeng Shen, Yanan Li, Cheng Cheng, Ryan Au, Feng Xu, Yajun Liu, Lei Zhu, Hong Shen.  (2022)  Gegen Qinlian decoction ameliorates murine colitis by inhibiting the expansion of Enterobacteriaceae through activating PPAR-γ signaling.  BIOMEDICINE & PHARMACOTHERAPY,      [PMID:36007273] [10.1016/j.biopha.2022.113571]
9. Gaowa Jin, Lijie Liu, Yuanliu Yang, Yan Zhang, Ping Zhao, Dongping Yu, Yongzheng Zhou, Zhimou Guo, Hui Wang, Xinmiao Liang.  (2022)  Preparative chromatography behavior of palmitoleic acid on octadecyl stationary phases with different densities.  JOURNAL OF SEPARATION SCIENCE,  45  (11): (1866-1873).  [PMID:35324071] [10.1002/jssc.202101021]
10. Zhu Bo, Chen Yumei, Guo Min, zhang Chenhui, Huang Lingxiao, Pan Qiangwei, Lin Tao, Lu Yiyi, Shen Xiaolu, Zhang Hongping.  (2022)  Berberine attenuates hyperalgesia in mice with adenomyosis.  ARCHIVES OF GYNECOLOGY AND OBSTETRICS,  306  (1): (115-125).  [PMID:35230500] [10.1007/s00404-022-06438-y]
11. Ming Guan, Xiaojing Kang, Le Wei, Xingjun Hu, Chao Han, Xing Li, Hanwen Liu, Liang Qu, Zhenwen Zhao.  (2022)  A dual-mode strategy combining SERS with MALDI FTICR MS based on core-shell silver nanoparticles for dye identification and semi-quantification in unearthed silks from Tang Dynasty.  TALANTA,      [PMID:35121543] [10.1016/j.talanta.2022.123277]
12. Kim Gowoon, Xu Yijuan, Zhang Jiarong, Sui Zhongquan, Corke Harold.  (2022)  Antibacterial Activity and Multi-Targeting Mechanism of Dehydrocorydaline From Corydalis turtschaninovii Bess. Against Listeria monocytogenes.  Frontiers in Microbiology,      [PMID:35087499] [10.3389/fmicb.2021.799094]
13. Shan Zhang, Ruiqi Liang, Kun Xu, Shurong Zheng, Somnath Mukherjee, Peng Liu, Changhao Wang, Yashao Chen.  (2021)  Construction of multifunctional micro-patterned PALNMA/PDADMAC/PEGDA hydrogel and intelligently responsive antibacterial coating HA/BBR on Mg alloy surface for orthopedic application.  Materials Science & Engineering C-Materials for Biological Applications,      [PMID:35148866] [10.1016/j.msec.2021.112636]
14. Wu Xiuwen, Liu Xiaopeng, Yang Liang, Wang Yuanyu.  (2021)  Berberine Protects against Neurological Impairments and Blood-Brain Barrier Injury in Mouse Model of Intracerebral Hemorrhage.  NEUROIMMUNOMODULATION,  29  (4): (317-326).  [PMID:34942622] [10.1159/000520747]
15. Xiang Zhou, Haojie Ye, Xiuhui Gao, Yumei Feng, Wubin Shao, Puying Qi, Zhibing Wu, Liwei Liu, Peiyi Wang, Song Yang.  (2021)  The discovery of natural 4'-demethylepipodophyllotoxin from renewable Dysosma versipellis species as a novel bacterial cell division inhibitor for controlling intractable diseases in rice.  INDUSTRIAL CROPS AND PRODUCTS,      [PMID:] [10.1016/j.indcrop.2021.114182]
16. Kun Yan, Lancheng Wang, Huimin Zhou, Zhendong Hua, Peng Xu, Hui Xu, Youmei Wang, Bin Di, Chi Hu.  (2021)  Cucurbituril-mediated AIE: An unconventional indicator displacement assay for ketamine detection.  DYES AND PIGMENTS,      [PMID:] [10.1016/j.dyepig.2021.109875]
17. Chen Yi, Jiang Zhaohui, Xu Jinzhuan, Zhang Jiyuan, Sun Runbin, Zhou Jia, Lu Yuan, Gong Zipeng, Huang Jing, Shen Xiangchun, Du Qianming, Peng Jianqing.  (2021)  Improving the ameliorative effects of berberine and curcumin combination via dextran-coated bilosomes on non-alcohol fatty liver disease in mice.  JOURNAL OF NANOBIOTECHNOLOGY,  19  (1): (1-18).  [PMID:34348707] [10.1186/s12951-021-00979-1]
18. Guanghui Xu, Huiqi Wan, Litao Yi, Wei Chen, Youhua Luo, Yiqi Huang, Xiaojuan Liu.  (2021)  Berberine administrated with different routes attenuates inhaled LPS-induced acute respiratory distress syndrome through TLR4/NF-κB and JAK2/STAT3 inhibition.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:34284014] [10.1016/j.ejphar.2021.174349]
19. Wei Hu, Wei Zhou, Chenlu Wang, Zichun Liu, Zilin Chen.  (2021)  Rapid Analysis of Biological Samples Using Monolithic Polymer-Based In-Tube Solid-Phase Microextraction with Direct Mass Spectrometry.  ACS Applied Bio Materials,      [PMID:35006902] [10.1021/acsabm.1c00551]
20. Jing Liang, Ke Min, Piao Long, Xuqian Weng, Qun Huang, Bo Chen, Ming Ma.  (2021)  Selective adsorption of flavonoids on cerium-doped ferroferric oxide magnetic particles.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:33975082] [10.1016/j.chroma.2021.462189]
21. Fang Yuwei, Shi Kangpei, Lu Haining, Lu Lin, Qiu Bo.  (2021)  Mingmu Xiaomeng Tablets Restore Autophagy and Alleviate Diabetic Retinopathy by Inhibiting PI3K/Akt/mTOR Signaling.  Frontiers in Pharmacology,      [PMID:33927618] [10.3389/fphar.2021.632040]
22. Jia Jin, Ming Xu, Yixuan Liu, Zhixiao Ji, Kaili Dai, Lun Zhang, Lei Wang, Fei Ye, Gang Chen, Zhengbing Lv.  (2020)  Alginate-based composite microspheres coated by berberine simultaneously improve hemostatic and antibacterial efficacy.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:32563918] [10.1016/j.colsurfb.2020.111168]
23. Yucheng Li, Baoying Wang, Jiduo Shen, Ming Bai, Erping Xu.  (2020)  Berberine attenuates fructose-induced insulin resistance by stimulating the hepatic LKB1/AMPK/PGC1α pathway in mice.  PHARMACEUTICAL BIOLOGY,      [PMID:32393087] [10.1080/13880209.2020.1756349]
24. Ping Yang, Fang-Jing Li, Shi-Wen Huang, Man Luo, Wei Lin, Gao-Qing Yuan, Qi-Qin Li.  (2020)  Physiological and Transcriptional Response of Xanthomonas oryzae pv. oryzae to Berberine, an Emerging Chemical Control.  PHYTOPATHOLOGY,  110  (5):   [PMID:31961254] [10.1094/PHYTO-09-19-0327-R]
25. Yujuan Zhang, Jinhu Huang, Xiangxiu Li, Ci Fang, Liping Wang.  (2020)  Identification of Functional Transcriptional Binding Sites within Chicken Abcg2 Gene Promoter and Screening Its Regulators.  Genes,  11  (2): (186).  [PMID:32050731] [10.3390/genes11020186]
26. Han Xiuyan, Chen Changming, Yan Qiulong, Jia Liqiu, Taj Ayaz, Ma Yufang.  (2019)  Action of Dicumarol on Glucosamine-1-Phosphate Acetyltransferase of GlmU and Mycobacterium tuberculosis.  Frontiers in Microbiology,      [PMID:31481936] [10.3389/fmicb.2019.01799]
27. Wei Zhou, Yikun Liu, Xiaoyan Liao, Zilin Chen.  (2019)  Capillary electrophoresis-mass spectrometry using robust poly(ether ether ketone) capillary for tolerance to high content of organic solvents.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:30718059] [10.1016/j.chroma.2019.01.070]
28. Ruidi Shen, Li Zou, Shixin Wu, Tingting Li, Jing Wang, Jianmin Liu, Liansheng Ling.  (2019)  A novel label-free fluorescent detection of histidine based upon Cu2+-specific DNAzyme and hybridization chain reaction.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:30682646] [10.1016/j.saa.2019.01.062]
29. Yueyue Wu, Xinmei Huang, Min Yang, Jiong Xu, Zaoping Chen, Zhiyan Yu, Jun Liu.  (2018)  Ameliorative effect of berberine coated bio-active nanoparticles in acetaminophen induced hepato-renal damage in diabetic rats.  JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,      [PMID:30419520] [10.1016/j.jphotobiol.2018.10.015]
30. Li Zou, Tingting Li, Ruidi Shen, Shaozhi Ren, Liansheng Ling.  (2018)  A label-free light-up fluorescent sensing platform based upon hybridization chain reaction amplification and DNA triplex assembly.  TALANTA,      [PMID:30086897] [10.1016/j.talanta.2018.06.051]
31. Wei Zhou, Chenlu Wang, Xuemei Wang, Zilin Chen.  (2018)  Etched poly(ether ether ketone) jacket stir bar with detachable dumbbell-shaped structure for stir bar sorptive extraction.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:29680741] [10.1016/j.chroma.2018.04.022]
32. Wang Chenlu, Zhou Wei, Liao Xiaoyan, Zhang Wenpeng, Chen Zilin.  (2017)  An etched polyether ether ketone tube covered with immobilized graphene oxide for online solid phase microextraction of quaternary alkaloids prior to their quantitation by HPLC-MS/MS.  MICROCHIMICA ACTA,  184  (8): (2715-2721).  [PMID:] [10.1007/s00604-017-2262-8]
33. Qing Wang, Ling Tong, Lin Yao, Peng Zhang, Li Xu.  (2016)  Fingerprinting of traditional Chinese medicines on the C18-Diol mixed-mode column in online or offline two-dimensional liquid chromatography on the single column modes.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:27031576] [10.1016/j.jpba.2016.03.033]
34. Zixin Zhang, Wenpeng Zhang, Tao Bao, Zilin Chen.  (2015)  Jacket-free stir bar sorptive extraction with bio-inspired polydopamine-functionalized immobilization of cross-linked polymer on stainless steel wire.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:26141275] [10.1016/j.chroma.2015.06.031]
35. Hailiang Huang, Shuo Shi, Xuyue Zheng, Tianming Yao.  (2015)  Sensitive detection for coralyne and mercury ions based on homo-A/T DNA by exonuclease signal amplification.  BIOSENSORS & BIOELECTRONICS,      [PMID:25950941] [10.1016/j.bios.2015.04.076]
36. Jiawei Meng, Wenpeng Zhang, Tao Bao, Zilin Chen.  (2015)  Novel molecularly imprinted magnetic nanoparticles for the selective extraction of protoberberine alkaloids in herbs and rat plasma.  JOURNAL OF SEPARATION SCIENCE,  38  (12): (2117-2125).  [PMID:25832420] [10.1002/jssc.201500264]
37. Qing Wang, Zhi-Yuan Luo, Mao Ye, Yu-Zhuo Wang, Li Xu, Zhi-guo Shi, Lanying Xu.  (2015)  Preparation, chromatographic evaluation and application of adenosine 5′-monophosphate modified ZrO2/SiO2 stationary phase in hydrophilic interaction chromatography.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:25627970] [10.1016/j.chroma.2015.01.017]
38. Juan Zhang, Zilin Chen.  (2013)  Determination of Matrine and Oxymatrine in Sophora Flavescens by Nonaqueous Capillary Electrophoresis-Electrospray Ionization-Ion Trap-Mass Spectrometry.  ANALYTICAL LETTERS,      [PMID:] [10.1080/00032719.2012.726684]
39. Min Wenao, Wang Weiping, Chen Jianrong, Wang Aijun, Hu Zhide.  (2012)  On-line immobilized acetylcholinesterase microreactor for screening of inhibitors from natural extracts by capillary electrophoresis.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  404  (8): (2397-2405).  [PMID:22932810] [10.1007/s00216-012-6333-8]
40. Qihan Wang, Weiyi Shen, Wentao Shao, Hai Hu.  (2024)  Berberine alleviates cholesterol and bile acid metabolism disorders induced by high cholesterol diet in mice.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,      [PMID:38740003] [10.1016/j.bbrc.2024.150088]
41. Kai Hu, Zhiyu Zhang, Di Zhao, Lixin Li, Cheng Yang, Huahui Zeng, Shusheng Zhang, Zhenqiang Zhang.  (2024)  Berberine-based hypercrosslinked polymer: Advanced solid-phase microextraction for high-throughput analysis of aristolochic acids in environmental water and herbal plants.  TALANTA,      [PMID:39673978] [10.1016/j.talanta.2024.127333]
42. Jingjing Zhang, Weiran Li, Zhanhui Tao, Xiao Zhou, Xiying Chen, Jingya Zhou, Hanyue Sun, Yuan Fang, Yaqing Liu.  (2024)  Endogenous glucose-driven cascade reaction of nano-drug delivery for boosting multidrug-resistant bacteria-infected diabetic wound healing.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:38830319] [10.1016/j.jcis.2024.05.204]
43. Si-Jie Wu, Ran Feng, Ran Meng, Qiu-Ya Ji, Han Tao, Bao-Cai Xu, Bao Zhang.  (2024)  Exploring the binding mechanism and functional properties of lactoferrin-berberine complex: Based on multispectral analysis, molecular docking, and dynamics simulations.  FOOD CHEMISTRY,      [PMID:39426260] [10.1016/j.foodchem.2024.141639]
44. Shixiang Chen, Bochen Wei, Lili Wen, Penglian Wei, Yunlin Fu.  (2024)  Metabolomics analysis of bioactive compositions of Michelia macclurei Dany and its antioxidant and enzyme inhibitory activities.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,  105  (1): (635-648).  [PMID:39230063] [10.1002/jsfa.13860]
45. Yiming Zhang, Shengying Zhu, Yueming Gu, Yanjing Feng, Bo Gao.  (2024)  Network Pharmacology Combined with Experimental Validation to Investigate the Mechanism of the Anti-Hyperuricemia Action of Portulaca oleracea Extract.  Nutrients,  16  (20): (3549).  [PMID:39458543] [10.3390/nu16203549]
46. Jing Zhu, Qing Hong Zhang, Wen Wu Wang.  (2024)  Pattern Recognition of Alkaloids by Inhibiting the Catalytic Activity of Dopzymes for Dopamine.  ANALYTICAL CHEMISTRY,      [PMID:39014901] [10.1021/acs.analchem.4c01920]
47. Qianying Li, Baichuan Wang, Shiyu Peng, Hui Wei, Ping Li, Yuankui Leng, Xiaolin Huang.  (2024)  Photodynamic inactivation of Listeria monocytogenes using a natural aggregation-induced emission photosensitizer and its application in salmon preservation.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2024.115762]
48. Jialu Zhuang, Hao Zhang, Jin Wu, Danyou Hu, Tao Meng, Jing Xue, Hanyang Xu, Gang Wang, Hua Wang, Guiyang Zhang.  (2024)  Redox-Responsive AIEgen Diselenide-Covalent Organic Framework Composites Targeting Hepatic Macrophages for Treatment of Drug-induced Liver Injury.  Small,      [PMID:39140196] [10.1002/smll.202402656]
49. Yi Tan, Huan Sun, Yuanchen Lan, Haider Mohammed Khan, Hui Zhang, Linli Zhang, Fengying Zhang, Yujia Cui, Lan Zhang, Dingming Huang, Xinmei Chen, Changchun Zhou, Jianxun Sun, Xue-Dong Zhou.  (2024)  Study of 3D Printed MXene-Berberine-Integrated Scaffold for Photo-Activated Antibacterial Property and Bone Regeneration.  Journal of Materials Chemistry B,      [PMID:38323437] [10.1039/D3TB02306K]
50. Menglan Wang, Lewei Li, Lifang Tang, Zuowei Xiao, Hong Yang, Qian Luo, Shiyang Fu, Zehui Fan, Xiaojun Tao, Chunlian He, Xiong Wu.  (2025)  Synergistic anti-Triple Negative Breast Cancer Study with Paclitaxel/Berberine Nanoparticle Co-Delivery System.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2025.106835]
51. He Feng, Yang-Jian Hong, Qi-Qi Zheng, Jia-Ming Ge, Hong-Wei Cheng, Yu-Peng Liu, Jie Deng, Qing-Lin Li, Song-Nan Qu.  (2025)  Bovine serum albumin modified carbon dots and berberine composite promotes tumor mitochondrial dysfunction and apoptosis.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:40706365] [10.1016/j.jcis.2025.138500]
52. Jie Yang, Fanlei Yang, Wenhao Xu, Xiuqin Yu, Zhaozhu Zheng, Xiaoqin Wang, Kaili Chen, Jia Yu, Gang Li.  (2025)  Composite Hydrogel Dressing with Drug-Release Capability and Enhanced Mechanical Performance.  BIOMACROMOLECULES,      [PMID:40793969] [10.1021/acs.biomac.5c00505]
53. Huiyu He, Rui Wang, Rongbin Nie, Nan Dong.  (2025)  An environmentally friendly cucurbit[7]uril-mediated magnetic-assisted matrix solid-phase dispersion extraction combined with HPLC-MS/MS for multiple analysis of pharmaceuticals and personal care products in aquatic organisms.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.115146]
54. Weiwei Zhang, Xiaokuo Shen, Hua Liu, Jun Wang, Yongqi Yang, Lin Gui, Ping Song, Wanzhen Li, Longbao Zhu, Fei Ge.  (2025)  Self-Oxygenating Nano-Thermosensitive Hydrogel System Integrated with Photothermal/Photodynamic Therapy for Antibacterial Therapy and Enhanced Wound Healing.  ACS Applied Bio Materials,      [PMID:40956300] [10.1021/acsabm.5c00455]
55. Xiaodan Zheng, Ruolong Ma, Ziyan Song, Limeng Zhang, Chuanda Ruan, Wenzhi Yang, Yi Zhang, Xiaohui Yan, Fei Tian.  (2025)  Self-Assembled Synergistic Nanoparticles from Carrier-Free Berberine and Ferulic Acid for Improved Antibacterial Activity.  ChemistrySelect,  10  (35): (e03533).  [PMID:] [10.1002/slct.202503533]
56. Qing Wang, Jie Chen, Kun Huang, Xin Zhang, Li Xu, Zhi-guo Shi.  (2014)  Preparation, characterization and application of N-methylene phosphonic acid chitosan grafted magnesia–zirconia stationary phase.  ANALYTICA CHIMICA ACTA,      [PMID:25479884] [10.1016/j.aca.2014.11.022]
57. Liyun Ma, Si-Min Liu, Lin Yao, Li Xu.  (2014)  Preparation and chromatographic performance evaluation of cucurbit[7]uril immobilized silica.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:25528071] [10.1016/j.chroma.2014.12.002]
58. Qing Wang, Jing Li, Xin Yang, Li Xu, Zhi-guo Shi, Lan-Ying Xu.  (2014)  Investigation on performance of zirconia and magnesia–zirconia stationary phases in hydrophilic interaction chromatography.  TALANTA,      [PMID:25127617] [10.1016/j.talanta.2014.06.016]
59. Songjie Fan, Xiaotian Chang, Yan Qiao, Xiaoxiao Zhao, Jiafu Zhao, Heshui Zhu, Yingqian Han, Chao Zhang.  (2025)  Tandemly Repeated G-Quadruplex Structures in the Pseudorabies Virus Genome: Implications for Epiberberine-Based Antiviral Therapy.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  26  (8): (3764).  [PMID:40332400] [10.3390/ijms26083764]
60. Runtian Xu, Hanping He, Huan Deng, Yuehan Dong, Xiangjie Wu, Zinuo Xia, Yang Zhou, Lin Yang, Zhijun Huang, Wenjin Xu, Peihu Xu, Haixing Xu.  (2025)  Study of conductive nerve conduits for anti-inflammatory and antioxidant effects.  RSC Advances,  15  (18): (14136-14151).  [PMID:40313319] [10.1039/D5RA00997A]
61. Shiwen Gong, Wentao Ma, Die Hu, Haixing Xu, Binbin Li, Xinyu Wang.  (2025)  A novel pH-responsive berberine-loaded attapulgite microsphere for IBD therapy via the regulation of gut immunity and flora.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:40381667] [10.1016/j.ijpharm.2025.125705]
62. Mengyuan Li, Jinling Guo, Jiaming Ge, Jingwen Yao, Lin Ma, Zheng Li, Xiangli Han, Ming Liu, Fei Tian, Jing Zhao.  (2025)  The Construction of Polyethylene Glycol-Folic Acid Modified Magnetic Layered Hydroxide Nanoplatform for Controlled Drug Delivery.  JOURNAL OF APPLIED POLYMER SCIENCE,      [PMID:] [10.1002/app.57245]
63. He Qiongyao, He Wu, Ren Yanlin, Wu Wenbin, Dong Hui, Yuan Gang, Ren Huihui, Wang Xinwei, Lu Fuer, Wang Dingkun.  (2025)  PRPF19 mediates the proteasomal degradation of VDR to exacerbate ferroptosis in diabetic nephropathy.  Cell Communication and Signaling,  23  (1): (1-21).  [PMID:40414879] [10.1186/s12964-025-02253-5]
64. Xuan Li, Shiyu Meng, Jiayi Liu, Meixian Sun, Mao Zhou, Fengtao Ji, Yu Hong.  (2025)  Berberine Ameliorates Postoperative Cognitive Dysfunction in Aged Mice and Regulates the PI3K‐AKT Pathway: A Network Pharmacology Study.  JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,  29  (15): (e70744).  [PMID:40735856] [10.1111/jcmm.70744]
65. Runze Zhang, Kang Wang, Jinheng Wei, Lu Cheng, Zaiwei Wen, Yong Zhao, Lijun Xu, Renjun Pei.  (2025)  Cascade catalysis-based signal amplification for colorimetric detection of acetylcholinesterase and its inhibitors.  ANALYTICA CHIMICA ACTA,      [PMID:41241494] [10.1016/j.aca.2025.344784]
66. Wei Liu, Ruheng Wei, Jingya Xu, Zhilong Liu, Yulai Li.  (2025)  Inflammation-related biomarkers and berberine therapy in post-stroke depression: evidence from bioinformatics, machine learning, and experimental validation.  Frontiers in Neuroscience,      [PMID:41164411] [10.3389/fnins.2025.1684297]
67. Guangqi Guo, Zhen Zhang, Xiaoyang Xia, Zhixiong He, Nanjie Jiang, Xiang Liu, Xia Xiang, Yanan Xue.  (2025)  Berberine-oleanolic acid self-assembled nanoparticles: Enhanced stability, cellular uptake, and anti-inflammatory activity.  JOURNAL OF MOLECULAR STRUCTURE,      [PMID:] [10.1016/j.molstruc.2025.144577]
68. Chu Xini, Li Jingguo, Wang Di, Gan Liyu, Liu Xu, Feng Zeyu, Yang Peng, Zhang Hongli, Xie Yifan, Wang Fei, Zou Gang.  (2025)  Twisted-stacking MOF patterns with tailorable circularly polarized luminescence properties and encryption applications.  Nature Communications,  16  (1): (10347).  [PMID:41285726] [10.1038/s41467-025-65310-0]
69. Tingfang Jia, Zhaohui Yang, Xin Yue, Da-Yuan Wang, Linqi Shi, Jing Shen.  (2025)  Multifunctional drug in drug nano-assembly with antibiofilm and remineralization for preventing dental caries.  Materials Today Advances,      [PMID:] [10.1016/j.mtadv.2025.100668]
70. Ting Liu, Jia Tang, Xinyi Lu, Lu Jiang, Rui Zhang, Miaoqing Zhang, Jingpu Zhang, Danqing Song, Dousheng Zhang, Mingzhe Xu.  (2025)  Ocular Toxicity and Mechanistic Investigation for Berberine and Its Metabolite Berberrubine on Zebrafish.  MOLECULES,  30  (23): (4602).  [PMID:41375198] [10.3390/molecules30234602]
71. Chenliang Chu, Liang Qin, Huayong Peng, Tao Kuang, Yongshi Li, Xin Wang, Fenglan Liang, Ping Gao, Xiaoxiong Wang, Deyun Ma.  (2025)  The Mechanism of Emodin Against Methicillin-Resistant Staphylococcus aureus Infection and Research on Synergistic Antibiotics.  Life-Basel,  15  (12): (1920).  [PMID:41465858] [10.3390/life15121920]
72. Jin Liang, Yanzhi Liu, Fengyi Liu, Xiaoying Zhang, Yue Su, Jun Wang, Fang Duan, Gang Wu, Kai Qiu.  (2025)  High oxygen barrier and synergistically enhanced photodynamic antibacterial films via Berberine/layered double hydroxide for food packaging.  FOOD RESEARCH INTERNATIONAL,      [PMID:41652691] [10.1016/j.foodres.2025.118277]
73. XinYu Mao, ShangNong Wu, MengHui Zhang, Peng Shen, XiaoZhong Yang, HongGang Wang.  (2026)  Mitochondria-targeted pH/glucose dual-responsive ZIF-8 nanocarrier Co-delivering GOX and BBR for synergistic antitumor therapy.  MATERIALS & DESIGN,      [PMID:] [10.1016/j.matdes.2026.115512]
74. Wen-Jing Zhao, Xin-Yue Wang, Jin-Shuang Wang, Yuan-Yuan Cui, Cheng-Xiong Yang.  (2026)  Efficient solid-phase extraction of quaternary ammonium alkaloids from traditional Chinese medicines on a novel sulfonic acid group functionalized microporous organic network coated SiO2 composite.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:41621247] [10.1016/j.chroma.2026.466756]
75. Liu Xiao-cui, Liu Ya-ge, Lv Yong-ning, Deng Bin.  (2026)  Berberine Alleviates Pancreatic β-Cell Ferroptosis and Injury in db/db Mice by Regulating the AGE/RAGE Pathway: Insight from Proteomic Analysis.  Current Medical Science,      [PMID:41637032] [10.1007/s11596-026-00168-x]
76. Ran Xie, Lixia Song, Yuling Liu, Qi Song, Jiameng Li, Yanmin Zhang, Jing Meng, Baokai Dou, Xiaoyu Hu, Lv Gao, Qinghe Zhao, Hairu Huo, Feng Sui.  (2026)  Integration of Non-Targeted Metabolomics and Transcriptomics Reveals the Mechanistic Rationale of Coptidis Rhizoma's Cold Property via Systemic Energy Homeostasis and Adaptive Thermogenesis in Mice.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:41663004] [10.1016/j.jep.2026.121344]
77. Jinyao Chen, Ming Zhang, Yeji Wang, Zhiyu Xie, Fei Yang, Hongjun Yu, Di Zhang, Min Fang, Xiaoyi Luan, Xueyang Jin, Xue Wang, Yanan Qiao, Shicun Zheng, Xiuyun Li, Wenqiang Chang, Hongxiang Lou.  (2026)  Exporter Mdr1 as an importer is an achilles’ heel for combating drug-resistant Candida.  Cell Chemical Biology,  33  (2): (227-240).  [PMID:41720080] [10.1016/j.chembiol.2026.01.009]
78. Ying Zhao, Yubo Lu, Yushan Ma, Sijia Wang, Pin Lv, Huifang Xu, Yuanyuan Li, Weisheng Feng.  (2026)  Self-Assembled Berberine-Sinapic Acid Nanomedicine for Synergistic Chemotherapy.  MOLECULES,  31  (4): (621).  [PMID:41752398] [10.3390/molecules31040621]
79. Yu Qin, Huiling Liu, Yan Zhang, Fei Li, Zhiwei Deng, Zhengshan Luo, Yuhao Zhuang, Kai Fu, Zhenbo Yuan, Yijian Rao.  (2026)  Engineering Plant-Derived P450 Enables the Efficient Production of Berberine through a Concise and Modular Enzymatic Cascade in E. coli.  JACS Au,      [PMID:] [10.1021/jacsau.6c00169]
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