Betamethasone - Moligand™, 10mM in DMSO , Agonist of Glucocorticoid receptor, CAS No.378-44-9, Agonist of Glucocorticoid receptor

CAS: 378-44-9 Cat. No.: B408310 Peso molecular: 392.46 Número EC: 206-825-4

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

NSC-39470, SCH-4831 | (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,13,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3(9H,10H,14H)-one

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Betamethasone Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
In vitro

Betamethasone has a specific affinity for type II glucocorticoid receptors which are present in most brain regions.

In vivo

Betamethasone has direct vasoconstrictor effects on peripheral femoral resistance vessels in late gestation fetal sheep. Betamethasone exposure decreases cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 hours of infusion in sheep. Betamethasone reduces the activation of NF-kappaB and elevation of TNFalpha and IL-1beta, and induces the expression of IL-10 in the brain, all of which correlate with the changes of pain thresholds in rats. Betamethasone exposure reduces synaptophysin-LI in the frontal neocortex, caudate putamen and hippocampus by 46.9%, 41.0% and 55.4%, respectively, that is not accompanied by irreversible neuronal damage in the fetal sheep brain. Betamethasone modestly increases cytidylyltransferase (CT) mRNA, but does not alter the levels of immunoreactive enzyme in adult rat lung. Betamethasone decreases the activities of the sphingomyelin hydrolases: acid sphingomyelinase by 33% and of alkaline ceramidase by 21%. Betamethasone injected at the time of nerve injury partially inhibits the development of neuropathic hyperalgesia and reduces the subsequent elevated levels of pro-inflammatory cytokines in the brain of rats, while stimulating the expression of the anti-inflammatory cytokine IL-10.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥96%

Specifications

Sinónimos

NSC-39470, SCH-4831 | (8S, 9R, 10S, 11S, 13S, 14S, 16S, 17R)-9-fluoro-11, 17-dihydroxy-17-(2-hydroxyacetyl)-10, 13, 16-trimethyl-7, 8, 11, 12, 13, 15, 16, 17-octahydro-6H-cyclopenta[a]phenanthren-3(9H, 10H, 14H)-one

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

AGONIST

Mecanismo de acción

Agonist of Glucocorticoid receptor

Propiedades del producto

• ALogP: 1.9

Nombres e identificadores

• Isómeros SMILES: C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C
• WGK Alemania: 3
• Peso molecular: 392.46
• Reaxy-Rn: 2341697
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2341697&ln=

Objetivos asociados (humanos)

NR3C1 Tclin Glucocorticoid receptor (3 Activities)

Discover Target: NR3C1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Punto de fusión (°C): 234-236°C

Referencias

1. Yuan Liang, Zhuolin Li, Jie Zhang, Tiezhu Li, Chengyu Lv.  (2023)  Comparison of the Glucocorticoid Receptor Binding and Agonist Activities of Typical Glucocorticoids: Insights into Their Endocrine Disrupting Effects.  CHEMISTRY & BIODIVERSITY,      [PMID:38129310] [10.1002/cbdv.202301525]

2. Yuan Huang, Zhiqun Zheng, Liying Huang, Hong Yao, Xiao shan Wu, Shaoguang Li, Dandan Lin.  (2017)  Optimization of dispersive liquid-phase microextraction based on solidified floating organic drop combined with high-performance liquid chromatography for the analysis of glucocorticoid residues in food.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:28259095] [10.1016/j.jpba.2017.02.026]

3. Yirong Ma, Min Gong, Xinran Wei, Fan Yang, Yunzhe Li, Guanjun Nan, Zhimin Luo, Aiguo Zeng.  (2025)  A Two-Step Electropolymerization Strategy to Construct an Electrochemical Sensor for Sensitive Detection of Illegal Addition of Betamethasone in Cosmetics.  JOURNAL OF THE ELECTROCHEMICAL SOCIETY,      [PMID:] [10.1149/1945-7111/adbdf3]

4. Chunyi Yu, Xujing Kong, Wenting Li, Boyu Li, Baorong Chen, Mengyao Gao, Susu Cai, Yun Wei.  (2025)  Magnetic molecularly imprinted polymers coupled with UPLC-MS/MS for simultaneous detection of 19 steroid hormones in human plasma.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:39793446] [10.1016/j.chroma.2025.465655]