Betaxolol HCl - 10mM in DMSO , Beta-1 adrenergic receptor antagonist, CAS No.63659-19-8, Beta-1 adrenergic receptor antagonist

CAS: 63659-19-8 Cat. No.: B408697 Peso molecular: 343.89 Número EC: 264-384-3

GRADE & PURITY 10mM in DMSO

Synonyms

SL 75212 HCl | 1-​[4-​[2-​(cyclopropylmethoxy)​ethyl]​phenoxy]​-​3-​[(1-​methylethyl)​amino]​-2-​propanol,hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Betaxolol (SL 75212) is aβ1adrenergic receptorblocker withIC50of 6 μM.
In vitro

Betaxolol is able to protect retinal neurones. Betaxolol attenuates the NMDA-induced influx of ⁴⁵Ca²⁺ while β-adrenoreceptor agonists are ineffective. The glutamate-induced release of LDH is almost completely prevented when betaxolol (10 μM) is included. Betaxolol (100 μM) is very effective in preventing the hypoxia-induced release of LDH from cortical cultures.

In vivo

When Betaxolol is injected i.p. into the rats before ischaemia and on the days of reperfusion the changes to the calretinin and ChAT immunoreactivities are reduced and the reduction of the b-wave is prevented. Inclusion of betaxolol partially prevents the changes caused by NMDA and lack of oxygen/glucose.
Cell Data

cell lines：

Concentrations：100 μM

Incubation Time：4 hours

Powder Purity:≥99%

Specifications

Sinónimos

SL 75212 HCl | 1-​[4-​[2-​(cyclopropylmethoxy)​ethyl]​phenoxy]​-​3-​[(1-​methylethyl)​amino]​-2-​propanol, hydrochloride (1:1)

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Betaxolol (SL 75212) is a β₁ adrenergic receptor blocker with IC50 of 6 μM.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

ANTAGONIST

Mecanismo de acción

Beta-1 adrenergic receptor antagonist

Nombres e identificadores

• Isómeros SMILES: CC(C)NCC(COC1=CC=C(C=C1)CCOCC2CC2)O.Cl
• Peso molecular: 343.89
• Reaxy-Rn: 5182512
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5182512&ln=

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 32 mg/mL (196.09 mM); Water: 32 mg/mL (196.09 mM); Ethanol: 32 mg/mL (196.09 mM)

Referencias

1. Xiaofei Ma, Chengchen Zhang.  (2024)  Clindamycin phosphate-based deep eutectic solvent as a chiral selector for enantioseparation of amino alcohol drugs in nonaqueous capillary electrophoresis.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:39326379] [10.1016/j.chroma.2024.465388]