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Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Bethanidine sulfate and its ortho-chloro derivative (BW 392C60) are potent adrenergic neurone blockers with sympathomimetic effects similar to bretylium and guanethidine in various animal models, particularly in cats. They inhibit the release of noradrenaline during nerve stimulation and enhance smooth muscle responses to adrenaline and noradrenaline. Bethanidine sulfate increases pressor responses to tyramine, though this effect diminishes with higher doses. Unlike guanethidine, Bethanidine sulfate does not deplete pressor amine content in the iris of cats post-administration. It also briefly inhibits autonomic cholinergic mechanisms and causes temporary neuromuscular paralysis in large doses, contrasting with its prolonged adrenergic neurone blocking effects.
| Sonrisas canónicas | CNC(=NC)NCC1=CC=CC=C1.CNC(=NC)NCC1=CC=CC=C1.OS(=O)(=O)O |
|---|---|
| IUPAC Name | 1-benzyl-2,3-dimethylguanidine;sulfuric acid |
| InChIKey | YTIJUXVIZLYQTB-UHFFFAOYSA-N |
| INCHI | 1S/2C10H15N3.H2O4S/c2*1-11-10(12-2)13-8-9-6-4-3-5-7-9;1-5(2,3)4/h2*3-7H,8H2,1-2H3,(H2,11,12,13);(H2,1,2,3,4) |
| Isómeros SMILES | CNC(=NC)NCC1=CC=CC=C1.CNC(=NC)NCC1=CC=CC=C1.OS(=O)(=O)O |
| CAS alternativo | 114-85-2 |
| PubChem CID | 16051931 |
| Términos de entrada MeSH | Batel;Betanidine;Bethanidine;Bethanidine Sulfate;Bethanidine, Sulfate (2:1);Sulfate, Bethanidine |
| Peso molecular | 452.6 |
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