GRADE & PURITY ≥98%

Synonyms

(R,E)-11,26,7-trimethyl-56-((4-methylpiperazin-1-yl)methyl)-52,53-dihydro-11H,51H-11-oxa-4-aza-5(2,1)-benzo[d]imidazola-2(2,4)-pyridina-1(4,5)-pyrazolacycloundecaphan-3-one

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Information

BI-4020 BI-4020 is a highly active, non-covalent EGFR inhibitor with IC50 of 0.6 nM.

Targets

EGFR^{del19 T790M C797S} (anti-proliferation potency); EGFR^{del19 T790M C797S} (biomarker potency) 0.2 nM; 0.6 nM

Cell Research(from reference)

Cell lines：BaF3 cells 

Incubation Time：4 h, 3 days 

Specifications

Sinónimos

(R, E)-11, 26, 7-trimethyl-56-((4-methylpiperazin-1-yl)methyl)-52, 53-dihydro-11H, 51H-11-oxa-4-aza-5(2, 1)-benzo[d]imidazola-2(2, 4)-pyridina-1(4, 5)-pyrazolacycloundecaphan-3-one

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

BI-4020 is an orally active, non-covalent EGFR inhibitor with IC50 of 0.6 nM and 0.2 nM for EGFR^{del19 T790M C797S} as biomarker potency and anti-proliferation potency in BaF3 cells, respectively.

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

• Peso molecular: 542.68

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro Ethanol: 30 mg/mL (55.28 mM); Water: 20 mg/mL (36.85 mM); DMSO: 15 mg/mL (27.64 mM)