BL 1249 - Moligand™, ≥98% , Activator of K 2P10.1;Activator of K 2P2.1, CAS No.18200-13-0, Activator of K 2P10.1;Activator of K 2P2.1

CAS: 18200-13-0 Cat. No.: B286784 Peso molecular: 291.35 Número EC: 634-043-7

GRADE & PURITY Moligand™, ≥98%

Synonyms

5,6,7,8-Tetrahydro-N-[2-(2H-tetrazol-5-yl)phenyl]-1-naphthalenamine | J-011649 | EX-A7623 | N-[2-(2H-tetrazol-5-yl)phenyl]-5,6,7,8-tetrahydronaphthalen-1-amine | 1-Naphthalenamine, 5,6,7,8-tetrahydro-N-(2-(1H-tetrazol-5-yl)phenyl)- | SCHEMBL339107 | BL-12

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

BL-1249 is a nonsteroidal anti-inflammatory agent (NSAID) and a potassium channel activator. BL-1249 potently activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2) with EC50 values of 5.5 μM and 8.0 μM, respectively. BL-1249 extracellular application activates all TREK subfamily members but has no effect on other K2P subfamilies. BL-1249 exhibits more selective for the bladder (EC50 of 1.26 μM) than vascular tissue (EC50 of 21.0 μM). 

Application：

BL-1249 has been used:
as an activator of mechano-gated K2P channel in contracted mouse ileum and colon tissues
as a TWIK related potassium channel (TREK2) modulator and in U-2 OS osteosarcoma cell line
as a TREK1 and TREK2 activator in mice.

Specifications

Sinónimos

5, 6, 7, 8-Tetrahydro-N-[2-(2H-tetrazol-5-yl)phenyl]-1-naphthalenamine | J-011649 | EX-A7623 | N-[2-(2H-tetrazol-5-yl)phenyl]-5, 6, 7, 8-tetrahydronaphthalen-1-amine | 1-Naphthalenamine, 5, 6, 7, 8-tetrahydro-N-(2-(1H-tetrazol-5-yl)phenyl)- | SCHEMBL339107 | BL-12

Especificaciones y pureza

Moligand™, ≥98%

Mecanismos bioquímicos y fisiológicos

K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channel opener (EC50values are 5.5 μM and 8 μM, respectively). Exhibits selectivity for bladder over vascular tissuein vitroandin vivo(EC50values are 1.26 and 21.0μM for cultured bladder and aortic tissues respectivel

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

ACTIVATOR

Mecanismo de acción

Activator of K 2P10.1;Activator of K 2P2.1

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: C1CCC2=C(C1)C=CC=C2NC3=CC=CC=C3C4=NNN=N4
• IUPAC Name: N-[2-(2H-tetrazol-5-yl)phenyl]-5,6,7,8-tetrahydronaphthalen-1-amine
• InChIKey: YYNRZIFBTOUICE-UHFFFAOYSA-N
• INCHI: 1S/C17H17N5/c1-2-8-13-12(6-1)7-5-11-15(13)18-16-10-4-3-9-14(16)17-19-21-22-20-17/h3-5,7,9-11,18H,1-2,6,8H2,(H,19,20,21,22)
• Isómeros SMILES: C1CCC2=C(C1)C=CC=C2NC3=CC=CC=C3C4=NNN=N4
• Peso molecular: 291.35
• Reaxy-Rn: 25842032
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25842032&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Azoles
      • Subclass Tetrazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Azoles
• Subclass: Tetrazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenyltetrazoles and derivatives
• Alternative Parents: Tetralins Aniline and substituted anilines Primary aromatic amines Heteroaromatic compounds Secondary amines Azacyclic compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenyltetrazole - Tetralin - Aniline or substituted anilines - Benzenoid - Primary aromatic amine - Monocyclic benzene moiety - Heteroaromatic compound - Azacycle - Secondary amine - Organic nitrogen compound - Hydrocarbon derivative - Organonitrogen compound - Amine - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as phenyltetrazoles and derivatives. These are compounds containing a phenyltetrazole skeleton, which consists of a tetrazole bound to a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

KCNK2 Tclin Potassium channel subfamily K member 2 (2 Activities)

Discover Target: KCNK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNK18 Tclin Potassium channel subfamily K member 18 (1 Activities)

Discover Target: KCNK18

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNK10 Tclin Potassium channel subfamily K member 10 (2 Activities)

Discover Target: KCNK10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

VDR Tclin Vitamin D receptor (26531 Activities)

Discover Target: VDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLK Tbio DNA polymerase kappa (8653 Activities)

Discover Target: POLK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

Discover Target: MEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNK10 Tclin Potassium channel subfamily K member 10 (76 Activities)

Discover Target: KCNK10

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

GCN5 Histone acetyltransferase GCN5 (89 Activities)

Discover Target: GCN5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNK2 Potassium channel subfamily K member 2 (9 Activities)

Discover Target: KCNK2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Solvent:1eq. NaOH, Max Conc. mg/mL: 29.14, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 29.14, Max Conc. mM: 100
• Sensibilidad: light & air sensitive
• Peso molecular: 291.350 g/mol
• XLogP3: 4.100
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 291.148 Da
• Monoisotopic Mass: 291.148 Da
• Topological Polar Surface Area: 66.500 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 363.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1