Cell-permeable, reversible inhibitor of non-muscle myosin II. Shows high affinity and selectivity for vertebrate and invertebrate Myosin II (IC 50 values 0.5-5 μM). Inhibits actin-activated MgATPase activity and in vitro motility of class II myosins.
Condiciones de almacenamiento de almacenamiento
Protected from light, Store at -20°C, Desiccated
Enviado en
Ice chest + Ice pads
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Tipo de acción
INHIBITOR
Nota
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for more information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This compound belongs to the class of organic compounds known as pyrroloquinolines. These are compounds containing a pyrroloquinoline moiety, which consists of a pyrrole ring fused to a quinoline.
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
1.Chen Li, Zihui Zheng, Xiang Wu, Qiu Xie, Ping Liu, Yunfeng Hu, Mei Chen, Liming Liu, Wangxing Zhao, Linlin Chen, Jun Guo, Ying Song. (2023) Stiff matrix induced srGAP2 tension gradients control migration direction in triple-negative breast cancer. Theranostics, [PMID:36593959][10.7150/thno.77313]
2.Yunfeng Hu, Qiu Xie, Shanshan Chen, Wangxing Zhao, Xudong Zhao, Qinli Ruan, Zihui Zheng, Huanhuan Zhao, Tonghui Ma, Jun Guo, Lei Li. (2022) Par3 promotes breast cancer invasion and migration through pull tension and protein nanoparticle-induced osmotic pressure. BIOMEDICINE & PHARMACOTHERAPY, [PMID:36179489][10.1016/j.biopha.2022.113739]
3.Siyuan Huang, Qi Su, Xiaoqiang Hou, Kuankuan Han, Shufang Ma, Bingshe Xu, Yingjun Yang. (2022) Influence of Colonies’ Morphological Cues on Cellular Uptake Capacity of Nanoparticles. Frontiers in Bioengineering and Biotechnology, [PMID:35711638][10.3389/fbioe.2022.922159]
4.Ying Song, Chen Li, Yahan Fu, Qiu Xie, Jun Guo, Guangming Li, Huiwen Wu. (2020) Inward Tension of Talin and Integrin-related Osmotic Pressure are involved Synergetically in the Invasion and Metastasis of Non-small Cell Lung Cancer. Journal of Cancer, [PMID:32742451][10.7150/jca.45494]
5.Yifan Wang, Xiaolong Zhang, Jilai Tian, Jinjun Shan, Yunfeng Hu, Yiqian Zhai, Jun Guo. (2019) Talin promotes integrin activation accompanied by generation of tension in talin and an increase in osmotic pressure in neurite outgrowth. FASEB JOURNAL, 33 (5):(6311-6326). [PMID:30768370][10.1096/fj.201801949RR]
6.Longjie Li, Weiran Qin, Jing Xie. (2025) Engineering Patterned Tumor Microtissues in 3D Microwells via Stress Relaxation-Regulated Cell-Matrix Interactions. Journal of Materials Chemistry B, [PMID:41003668][10.1039/D5TB01526J]
7.Ling Zhu, Zihui Zheng, Wang Li, Chenyi Shou, Ying Zhao, Lijun Zhang, Xiaoli Shi, Yunfeng Hu, Huanhuan Zhao, Huiwen Wu, Jun Guo. (2025) Osmotic Tension Asymmetry Drives Electrotactic Migration via PDLIM7-Polarized Microfilament Coordination in Breast Cancer Cells. Advanced Science, [PMID:41431193][10.1002/advs.202515246]
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