BMS-984923 - 10mM in DMSO , CAS No.1375752-78-5

CAS: 1375752-78-5 Cat. No.: B655206 Peso molecular: 374.82 PubChem CID: 69084898

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

BMS-984923, a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (K i = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo signaling without affecting physiological glutamate signaling.

In Vivo

BMS-984923 (7.5 mg/kg or 15 mg/kg, oral gavage, once) exhibits good oral bioavailability and BBB penetration . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57Bl6J male mice . Dosage: 7.5 mg/kg or 15 mg/kg (Pharmacokinetic Analysis) Administration: Oral gavage, once. Result: The plasma concentration exceeded 2 μM at 10 hr. Brain concentrations were nearly as high as plasma concentrations when measured 3 hr after a 7.5 mg/kg oral dose

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

BMS-984923, a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (K i = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo s

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

MODULATOR

Nombres e identificadores

• Isómeros SMILES: C1=CC=C(C=C1)C#CC2=CC(=CN=C2)[C@@H]3[C@H](OC(=O)N3)C4=CC=CC=C4Cl
• PubChem CID: 69084898
• Peso molecular: 374.82