Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Protected from light,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 2 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Britannin is an NLRP3 inhibitor with an IC 50 of 3.630 μM, exhibiting anti-inflammatory activity. Britannin inhibits the activation and assembly of the NLRP3 inflammasome by blocking the interaction between NLRP3 and NEK7 . Additionally, Britannin demonstrates antitumor activity by inhibiting the proliferation of tumor cells through blocking the interaction between HIF-1α and Myc, thereby suppressing PD-L1 expression and enhancing cytotoxic T lymphocyte activity. Britannin can also induce apoptosis and autophagy in liver cancer cells by activating ROS-regulated AMPK . Britannin holds promise for research in the fields of anti-inflammatory and antitumor therapeutics.
| Isómeros SMILES | C[C@@H]1C[C@H]2[C@H]([C@@H]([C@]3([C@H]1[C@H](C[C@@H]3O)OC(=O)C)C)OC(=O)C)C(=C)C(=O)O2 |
|---|---|
| Peso molecular | 366.41 |
| Reaxy-Rn | 1355416 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1355416&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Punto de ebullición (°C) | 491.8±45.0°C(Predicted) |
|---|---|
| Punto de fusión (°C) | 189-191 °C |
| 1. Chenwei Xiong, JingJing Shang, Zhentang Yu, Junjie Zhang, Kaisong Miao, Changlin Yu, Yong Huang, Yiping Weng, Xindie Zhou. (2024) Britanin alleviates chondrocyte ferroptosis in osteoarthritis by regulating the Nrf2-GPX4 axis. Arabian Journal of Chemistry, [PMID:] [10.1016/j.arabjc.2024.105918] |
| 2. Qinwei Lu, Junlin Zhu, Linxin Teng, Cuihua Chen, Lei Bi, Weiping Chen. (2024) Britannin inhibits hepatocellular carcinoma development and metastasis through the GSK-3β/β-catenin signaling pathway. PHYTOMEDICINE, [PMID:39427522] [10.1016/j.phymed.2024.156126] |
Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
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