Bucladesine calcium , CAS No.938448-87-4

CAS: 938448-87-4 Cat. No.: B648938 Peso molecular: 488.42 PubChem CID: 127255644

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Descripción general

Bucladesine calcium salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase ( PKA ) by increasing the intracellular level of cAMP. Bucladesine calcium salt acts as a phosphodiesterase ( PDE ) inhibitor.

In Vivo

Bucladesine (bilateral infusion of 10 mM or 100 mM) leads to a significant reduction in escape latency and travel distance (showing an improvement in spatial memory) compared to the control, as assesed by Morris water maze task in male rats. Bucladesine at 1 mM and 5 mM concentrations infused within minutes after 0.5 mg nicotine infusion improves spatial memory retention in male rats . ?\nBucladesine (10 mM/side) combined with Nicotine (0.5 mM/side) results in a significant increase in the ChAT and VAChT immunoreactivity in CA1 regions, and increase in the optical density and amount of ChAT and VAChT immunostaining correlates with the decrease in escape latency and traveled distance in rats treated with Nicotine and low dose of Bucladesine. ?\nBucladesine is absorbed very rapidly and almost completely when the aqueous solution is applied to the site where the skin has been excised. Bucladesine is absorbed rapidly but slower than in the full-thickness abrasion rat model in the case of stripped skin. ?\nBucladesine (single or multiple administration of an emulsion containing 1.5%) is capable of significantly reducing the inflammatory oedema in the arachidonic acid induced ear oedema model in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Mecanismos bioquímicos y fisiológicos

Bucladesine calcium salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase ( PKA ) by increasing the intracellular level of cAMP. Bucladesine calcium salt

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C, Desiccated

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Nombres e identificadores

• Sonrisas canónicas: CCCC(=O)NC1=C2C(=NC=N1)N(C=N2)C3C(C4C(O3)COP(=O)(O4)O)OC(=O)CCC.CCCC(=O)NC1=C2C(=NC=N1)N(C=N2)C3C(C4C(O3)COP(=O)(O4)O)OC(=O)CCC.[Ca]
• InChIKey: DRYMTGFYEAYJQR-NGVPHMJWSA-N
• INCHI: 1S/2C18H24N5O8P.Ca/c2*1-3-5-11(24)22-16-13-17(20-8-19-16)23(9-21-13)18-15(30-12(25)6-4-2)14-10(29-18)7-28-32(26,27)31-14;/h2*8-10,14-15,18H,3-7H2,1-2H3,(H,26,27)(H,19,20,22,24);/t2*10-,14-,15-,18-;/m11./s1
• PubChem CID: 127255644
• Peso molecular: 488.42

Propiedades químicas y físicas

• Solubilidad: H2O : 100 mg/mL (204.74 mM; Need ultrasonic) DMSO : ≥ 100 mg/mL (204.74 mM)