Bufexamac - Moligand™, 10mM in DMSO , Inhibitor of histone deacetylase 10;Inhibitor of histone deacetylase 6, CAS No.2438-72-4, Inhibitor of histone deacetylase 10;Inhibitor of histone deacetylase 6

CAS: 2438-72-4 Cat. No.: B407941 Peso molecular: 223.27 Número EC: 219-451-1

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

2-(4-butoxyphenyl)-N-hydroxyacetamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Bufexamac Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.
In vitro

Bufexamac is a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10). Treatment of peripheral blood mononuclear cells with bufexamac inhibits the secretion of IFN-α. Bufexamac is a frequent and relevant contact sensitizer. Bufexamac is a non-steroidal anti-inflammatory drug.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

2-(4-butoxyphenyl)-N-hydroxyacetamide

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of histone deacetylase 10;Inhibitor of histone deacetylase 6

Propiedades del producto

• ALogP: 1.9

Nombres e identificadores

• Isómeros SMILES: CCCCOC1=CC=C(C=C1)CC(=O)NO
• RTECS: AK8280000
• Peso molecular: 223.27
• Reaxy-Rn: 2646848
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2646848&ln=

Objetivos asociados (humanos)

HDAC6 Tclin Histone deacetylase 6 (1 Activities)

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC10 Tclin Histone deacetylase 10 (1 Activities)

Discover Target: HDAC10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Punto de fusión (°C): 164 °C(dec.)

Referencias

1. Yangzheng Huang, Shao-Lu Li, Zhenxing Fu, Genghao Gong, Yunxia Hu.  (2022)  Preparation of microporous organic solvent nanofiltration (OSN) composite membrane from a novel tris-phenol monomer.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2022.121985]