Bumetanide - Moligand™, 10mM in DMSO , Sodium-(potassium)-chloride cotransporter 2 inhibitor, CAS No.28395-03-1, Sodium-(potassium)-chloride cotransporter 2 inhibitor

CAS: 28395-03-1 Cat. No.: B407775 Peso molecular: 364.42 Número EC: 249-004-6

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Benzoic acid, 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Bumetanide Bumetanide (Bumex) is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respe
In vitro

In vivo

Cell Data

cell lines：MV-4-11, MM.1S, and K562 cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

Benzoic acid, 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Bumetanide (Bumex) is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

AGONIST, INHIBITOR

Mecanismo de acción

Sodium-(potassium)-chloride cotransporter 2 inhibitor

Propiedades del producto

• ALogP: 2.8

Nombres e identificadores

• Isómeros SMILES: CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2
• WGK Alemania: 3
• RTECS: DG4910000
• Peso molecular: 364.42
• Reaxy-Rn: 2185351
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2185351&ln=

Objetivos asociados (humanos)

SLC12A1 Tclin Solute carrier family 12 member 1 (1 Activities)

Discover Target: SLC12A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC12A2 Tclin Solute carrier family 12 member 2 (1 Activities)

Discover Target: SLC12A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Referencias

1. Chunyan Chen, Ping Fan, Lirong Zhang, Kaige Xue, Jiaheng Hu, Juan Huang, Weitian Lu, Jin Xu, Shiye Xu, Guoping Qiu, Jianhua Ran, Shengwei Gan.  (2022)  Bumetanide Rescues Aquaporin-4 Depolarization via Suppressing β-Dystroglycan Cleavage and Provides Neuroprotection in Rat Retinal Ischemia-Reperfusion Injury.  NEUROSCIENCE,      [PMID:36493910] [10.1016/j.neuroscience.2022.11.033]

2. Dao-Lai Zhang, Yu-Jing Sun, Ming-Liang Ma, Yi-jing Wang, Hui Lin, Rui-Rui Li, Zong-Lai Liang, Yuan Gao, Zhao Yang, Dong-Fang He, Amy Lin, Hui Mo, Yu-Jing Lu, Meng-Jing Li, Wei Kong, Ka Young Chung, Fan Yi, Jian-Yuan Li, Ying-Ying Qin, Jingxin Li, Alex R B Thomsen, Alem W Kahsai, Zi-Jiang Chen, Zhi-Gang Xu, Mingyao Liu, Dali Li, Xiao Yu, Jin-Peng Sun.  (2018)  Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.  eLife,      [PMID:29393851] [10.7554/eLife.33432]

3. Yang Yu, Fangyong Wang.  (2026)  Combined use of Bumetanide and MGE cell transplantation alleviates neuropathic pain and its mechanism after spinal cord injury in mice.  Frontiers in Immunology,      [PMID:41929507] [10.3389/fimmu.2026.1751436]