Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 9 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Busulfan (NSC-750) is a cell cycle non-specific alkylating antineoplastic agent. Busulfan inducesapoptosis.
In vitro
Busulfan inhibits the cobblestone area-forming cell frequency but fails to cause a significant increase in apoptosis in hematopoietic stem cell alike cells and progenitors. Busulfan inhibits the hematopoietic function of HSC alike cells and progenitors via an apoptosis-independent mechanism. Busulfan induces bone marrow hematopoietic cell senescence associated with an increased expression of p16Ink4a and p19Arf in a time-dependent manner. Busulfan, an alkylating agent that causes DNA damage by cross-linking DNAs and DNA and proteins, induces senescence in normal human diploid WI38 fibroblasts through the extracellular signal-regulated kinase (Erk) and p38 mitogen-activated protein kinase (p38 MAPK) cascade independent of the p53-DNA damage pathway. Busulfan induces a transient reduction in GSH but a continuous increase in ROS production. Busulfan-induced hypophosphorylation of Rb prevents apoptosis of spermatogonial stem cells by inhibiting PCNA expression in testicular cells.
In vivo
Busulfan-treated mice exhibit a marked increase in apoptosis and a decrease in testis weight. Busulfan is administered at the rate of 40 mg/kg body weight to induce a maximal number of apoptotic cells while minimizing the number of necrotic cells. Busulfan conditioning and irradiation results in comparable sensitivity of HSC detection as evaluated by limiting dilution analysis in NOD/SCID mice. Busulfan-transplanted mice has slow and incomplete lymphoid engraftment. Busulfan (20 mg/kg to 100 mg/kg) provides dose-dependent congenic lymphoid reconstitution in mice.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥98%
| ALogP | -0.5 |
|---|
| Isómeros SMILES | CS(=O)(=O)OCCCCOS(=O)(=O)C |
|---|---|
| RTECS | EK1750000 |
| Número ONU | 2811 |
| Grupo de embalaje | I |
| Peso molecular | 246.3 |
| Beilstein | 1791786 |
| Reaxy-Rn | 1791786 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1791786&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Punto de fusión (°C) | 114.0-118.0°C |
|---|
| 1. Leilei Gong, Jinli Hou, Hongjun Yang, Xueyan Zhang, Jingxia Zhao, Lan Wang, Xiaojie Yin, Xin Feng, Chenghong Yin. (2023) Kuntai capsule attenuates premature ovarian insufficiency by activating the FOXO3/SIRT5 signaling pathway in mice: A comprehensive study using UHPLC-LTQ-Orbitrap and integrated pharmacology. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:38145859] [10.1016/j.jep.2023.117625] |
| 2. Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye. (2022) Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme. Bioactive Materials, [PMID:36406255] [10.1016/j.bioactmat.2022.10.002] |
| 3. Yi Zhang, Qingbo Deng, Chang Tang, Minglu Zhang, Zilong Huang, Zhifeng Cai. (2022) Fluorescent folic acid-capped copper nanoclusters for the determination of rifampicin based on inner filter effect. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:36228492] [10.1016/j.saa.2022.121944] |
| 4. Jiao Sha, Zidan Cao, Zibo Huang, Yi Gong, Yameng Wan, Renren Sun, Haixia He, Gaoliang Jiang, Yu Li, Tao Li, Baozeng Ren. (2020) Solid-liquid phase equilibrium of busulfan in fifteen pure solvents: Solubility determination, solvent effect, model correlation and thermodynamic analysis. JOURNAL OF CHEMICAL THERMODYNAMICS, [PMID:] [10.1016/j.jct.2020.106328] |
| 5. Zhixia Yao, Hanmeng Liu, Yaosheng Liu, Yongxing Diao, Guangxing Hu, Qifang Zhang, Zhuang Li. (2020) FRET-based fluorometry assay for curcumin detecting using PVP-templated Cu NCs. TALANTA, [PMID:33298267] [10.1016/j.talanta.2020.121741] |
| 6. Feng Xiushan, Ling Li, Zhang Wenqian, Liu Xiaohan, Wang Yaping, Luo Yanjing, Xiong Zhengai. (2020) Effects of Human Amnion–Derived Mesenchymal Stem Cell (hAD-MSC) Transplantation In Situ on Primary Ovarian Insufficiency in SD Rats. Reproductive Sciences, 27 (7): (1502-1512). [PMID:31953773] [10.1007/s43032-020-00147-0] |
| 7. De-Yun Ma, Zhi Li, Jun-Xia Xiao, Rong Deng, Pei-Feng Lin, Rui-Qun Chen, Yun-Qiu Liang, Hai-Fu Guo, Bei Liu, Jian-Qiang Liu. (2015) Hydrostable and Nitryl/Methyl-Functionalized Metal–Organic Framework for Drug Delivery and Highly Selective CO2 Adsorption. INORGANIC CHEMISTRY, [PMID:26146847] [10.1021/acs.inorgchem.5b00335] |
| 8. Jinxingyi Wang, Ruyu Tao, Hanshuai Hu, Xue Lan, Jiejie Gao, Yanping Guan, Qian Liu. (2025) Therapeutic drug monitoring of busulfan and cyclophosphamide in hematologic malignancies: An LC-MS/MS development, validation and application. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, [PMID:40759333] [10.1016/j.vascn.2025.108389] |
| 9. Xiaofei Xin, Yifu Lyu, Huanyu Qin, Jinyu Dai, Di Wu, Yu Ding, Qiang Tian, Chao Qin, Na Li, Lifang Yin. (2026) Structure–Activity-Driven Multicompartment Lipid Nanoparticles for Synergistic mRNA and siRNA Codelivery in Acute Myeloid Leukemia. Journal of the American Chemical Society, [PMID:41719142] [10.1021/jacs.5c23209] |
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