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Butyzamide - ≥99% , CAS No.1110767-45-7
Disponible para pedir
GRADE & PURITY ≥99%
Storage
Store at 2-8°C,Protected from light,Desiccated
Shipped In
Wet ice
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Why this grade
≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at 2-8°C,Protected from light,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
Butyzamide is an orally active activator of Mpl , a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2 , STAT3 , STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay
In Vitro
Butyzamide (3 μM; 15 min) induces the phosphorylation of JAK2, STAT3, STAT5 and MAPK in Ba/F3-hMpl cells. Butyzamide (3 μM; 48 h) induces colony-forming unit-megakaryocyte and polyploid meggakaryocytes from human CD34 + hematopoietic progenitor cellls. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Butyzamide (10 mg/kg, 50 mg/kg; p.o.; once daily for 20 days) increases human platelets in NOG mice transplanted with human fetal liver-derived CD34 + cells . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:JAK2 STAT3 STAT5
Specifications
Especificaciones y pureza
≥99%
Mecanismos bioquímicos y fisiológicos
Butyzamide is an orally active activator of Mpl , a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2 , STAT3 , STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay.
Condiciones de almacenamiento de almacenamiento
Store at 2-8°C, Protected from light, Desiccated
Enviado en
Wet ice
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Tipo de acción
ACTIVATOR
Pureza
≥99%
Nombres e identificadores
| Peso molecular | 591.55 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
| Solubilidad | DMSO : 100 mg/mL (169.05 mM; Need ultrasonic) |
|---|
Calculadoras de soluciones
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