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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 23 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Calcitriol (RO215535, Topitriol, 1,25-Dihydroxyvitamin D3) is a nonselectivevitamin D receptoractivator/agonist(VDRA), exhibiting a 10-fold higher vitamin D receptor (VDR) binding affinity(IC50=0.4 nM) than the selective VDRA paricalcitol.Solutions are be
In vitro
Calcitriol is a potent inhibitor of PHA-induced lymphocyte proliferation, achieving 70% inhibition of tritiated thymidine incorporation after 72 h in culture. Calcitriol suppresses interleukin-2 (IL-2) production by PHA-stimulated peripheral blood mononuclear cells in a concentration-dependent fashion. Calcitriol increases the concentration of intracellular calcium ([Ca2+]i) within 5 s by mobilizing calcium from the endoplasmic reticulum and the formation of inositol 1,4, 5-trisphosphate and diacylglycerol. Calcitriol can inhibit the proliferation and promote the differentiation of human prostate adenocarcinoma cells. Calcitriol causes a selective decrease in the secreted levels of type IV collagenases (MMP-2 and MMP-9). Calcitriol has antiproliferative activity in squamous cell carcinoma and prostatic adenocarcinoma and enhances the antitumor activity of platinum-based agents. Calcitriol prior to paclitaxel significantly reduces clonogenic survival compared with either agent alone in the murine squamous cell carcinoma and PC-3 cells. Calcitriol is a potent anti-proliferative agent in a wide variety of malignant cell types. Calcitriol effects are associated with an increase in G0/G1 arrest, induction of apoptosis and differentiation, modulation of expression of growth factor receptors. Calcitriol potentiates the antitumor effects of many cytotoxic agents and inhibits motility and invasiveness of tumor cells and formation of new blood vessels.
In vivo
Cell Data
cell lines:U87MG, LNCaP and PC3 cells
Concentrations:
Incubation Time:
Powder Purity:≥99%
| ALogP | 5.1 |
|---|
| Isómeros SMILES | C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](C[C@@H](C3=C)O)O)C |
|---|---|
| WGK Alemania | 3 |
| RTECS | FZ4645000 |
| Peso molecular | 416.64 |
| Beilstein | 7559394 |
| Reaxy-Rn | 30827300 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=30827300&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Punto de fusión (°C) | 119°C(lit.) |
|---|
| 1. Chen An, Lan Zirong, Li Li, Xie Luting, Liu Xiaoyu, Yang Xiulin, Wang Siyi, Liang Qingchun, Dong Qianqian, Feng Liyun, Li Yining, Ye Yuanzhi, Fu Mingwei, Lu Lihe, Yan Jianyun. (2023) SGLT2 inhibitor canagliflozin alleviates vascular calcification through suppression of NLRP3 inflammasome. CARDIOVASCULAR RESEARCH, [PMID:37523743] [10.1093/cvr/cvad119] |
| 2. Pingcui Xu, Bingfeng Lin, Xuehui Deng, Kai Huang, Yan Zhang, Nani Wang. (2022) VDR activation attenuates osteoblastic ferroptosis and senescence by stimulating the Nrf2/GPX4 pathway in age-related osteoporosis. FREE RADICAL BIOLOGY AND MEDICINE, [PMID:36402439] [10.1016/j.freeradbiomed.2022.11.013] |
| 3. Zhengtian Lyu, Haifang Li, Xin Li, Hui Wang, Hongchao Jiao, Xiaojuan Wang, Jingpeng Zhao, Hai Lin. (2022) Fibroblast growth factor 23 inhibits osteogenic differentiation and mineralization of chicken bone marrow mesenchymal stem cells. POULTRY SCIENCE, [PMID:36442309] [10.1016/j.psj.2022.102287] |
| 4. Chen Xue-qi, Mao Jia-yu, Wang Chun-saier, Li Wen-bin, Han Tao-tao, Lv Ke, Li Jing-nan. (2022) CYP24A1 Involvement in Inflammatory Factor Regulation Occurs via the Wnt Signaling Pathway. Current Medical Science, 42 (5): (1022-1032). [PMID:36255661] [10.1007/s11596-022-2564-x] |
| 5. Xiaonan Chen, Yiqing Zou, Shuqi Zhang, Pengchao Fang, Shuxuan Li, Pengyu Li, Yingying Sun, Gang Yuan, Haiyan Hu. (2022) Multi-functional vesicles improve Helicobacter pylori eradication by a comprehensive strategy based on complex pathological microenvironment. Acta Pharmaceutica Sinica B, [PMID:36176916] [10.1016/j.apsb.2022.05.014] |
| 6. Yongzhi Cui, Yuanyuan Guo, Li Kong, Jingyu Shi, Ping Liu, Rui Li, Yongtao Geng, Weihang Gao, Zhiping Zhang, Dehao Fu. (2021) A bone-targeted engineered exosome platform delivering siRNA to treat osteoporosis. Bioactive Materials, [PMID:34901540] [10.1016/j.bioactmat.2021.09.015] |
| 7. Huiling Chen, Kaiqiang Hu, Yaru Liang, Yuqi Gao, Chenye Zeng, Kang Xu, Xiaojin Shi, Liyuan Li, Yuemiao Yin, Yi Qiao, Ying Qiu, Qingfei Liu, Zhao Wang. (2021) Ample dietary fat reduced the risk of primary vesical calculi by inducing macrophages to engulf budding crystals in mice. Acta Pharmaceutica Sinica B, [PMID:35256944] [10.1016/j.apsb.2021.08.001] |
| 8. Zehua Li, Ji Wu, Xiuli Zhang, Caiwen Ou, Xinglong Zhong, Yanting Chen, Lihe Lu, Hailin Liu, Yining Li, Xiaoyu Liu, Bo Wu, Yuxi Wang, Pingzhen Yang, Jianyun Yan, Minsheng Chen. (2019) CDC42 promotes vascular calcification in chronic kidney disease. JOURNAL OF PATHOLOGY, 249 (4): (461-471). [PMID:31397884] [10.1002/path.5334] |
| 9. Hailin Liu, Xiuli Zhang, Xinglong Zhong, Zehua Li, Shaoai Cai, Pingzhen Yang, Caiwen Ou, Minsheng Chen. (2019) Puerarin inhibits vascular calcification of uremic rats. EUROPEAN JOURNAL OF PHARMACOLOGY, [PMID:31085237] [10.1016/j.ejphar.2019.05.023] |
| 10. Meihui Fan, Guowen Zhang, Junhui Pan, Deming Gong. (2017) An inhibition mechanism of dihydromyricetin on tyrosinase and the joint effects of vitamins B6, D3 or E. Food & Function, 8 (7): (2601-2610). [PMID:28686246] [10.1039/C7FO00236J] |
| 11. Wang Sikai, Cheng Hongxia, Li Miaomiao, Gao Dongmei, Wu Haoran, Zhang Shanshan, Huang Yilan, Guo Kun. (2024) BNIP3-mediated mitophagy boosts the competitive growth of Lenvatinib-resistant cells via energy metabolism reprogramming in HCC. Cell Death & Disease, 15 (7): (1-18). [PMID:38969639] [10.1038/s41419-024-06870-9] |
| 12. Jiale Mao, Houxing Lei, Pingcui Xu, Shuang Liu, Jiwang Zhou, Mingrong Mei, Nani Wang, Xiaoqin Zhang. (2024) Identifying key components from Melastoma dodecandrum in TNF-α-induced osteoblast injury model through a combination of cell membrane chromatography and mass spectrometry. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:39326812] [10.1016/j.jep.2024.118836] |
| 13. Xiaoqin Zhang, Jiale Mao, Lu Shao, Shuang Liu, Jiwang Zhou, Mingrong Mei, Zunjing Zhang. (2024) Screening of active components of melastoma dodecandrum lour. against diabetic osteoporosis using cell membrane chromatography-mass spectrometry. Frontiers in Pharmacology, [PMID:39525628] [10.3389/fphar.2024.1450154] |
| 14. Fang Liu, Qingchun Liang, Li Li, Yuan Gong, Mingxi Li, Liyun Feng, An Chen, Yuanzhi Ye, Zirong Lan, Yining Li, Jing-Song Ou, Lihe Lu, Jianyun Yan. (2025) Thrombospondin-1 binds to integrin β3 to inhibit vascular calcification through suppression of NF-κB pathway. JOURNAL OF PATHOLOGY, [PMID:40084742] [10.1002/path.6417] |
| 15. Xuemin Xian, Xin Zhao, Xingchen Zhou, Hanfang Liu, Changxi Li, Xinquan Wu, Yuhang Chen, Keyue Ye, Hongwei Yang, Mingxi Li, Jianyun Yan, Xiuli Zhang. (2025) Honokiol attenuates oxidative stress and vascular calcification via the upregulation of heme oxygenase-1 in chronic kidney disease. TOXICOLOGY AND APPLIED PHARMACOLOGY, [PMID:40194744] [10.1016/j.taap.2025.117318] |
| 16. Zhenyu Zhu, Hao Liu, Liyun Feng, Lihe Lu, Jiahui Zhu, Qingchun Liang, Zirong Lan, Yuanzhi Ye, Siyi Wang, An Chen, Jianyun Yan. (2025) Loss of ADAMTS5 promotes vascular calcification via versican/integrin β1/FAK signal. ATHEROSCLEROSIS, [PMID:40215897] [10.1016/j.atherosclerosis.2025.119190] |
| 17. Zhu Mengyao, Ren Lu, Xiao Wenlong, Wang Longjian, Hu Zhiming, Wang Nani. (2025) Senkyunolide I suppresses hepatic stellate cell activation and liver fibrosis by reprogramming VDR-dependent fatty acid metabolism. Chinese Medicine, 20 (1): (1-17). [PMID:40514735] [10.1186/s13020-025-01133-x] |
| 18. Shangheng Fan, Youbo Yu, Yunqin Wei, Jing An, Qi Wang, Yan Yang. (2025) Targeting the mTOR-mitochondrial function axis: Calcitriol attenuates sarcopenic obesity with lipid dysregulation etiology. FREE RADICAL BIOLOGY AND MEDICINE, [PMID:41173312] [10.1016/j.freeradbiomed.2025.10.282] |
| 19. Ding Liu, Yuanzhi Ye, Zirong Lan, An Chen, Xingchen Zhou, Zhenhao Li, Xin Wen, Jisheng Xiao, Fan Ouyang, Jianyun Yan. (2025) Ultrasmall Cu2−xSe nanoparticles alleviate vascular calcification through inhibiting oxidative stress and NF-κB/NLRP3-mediated inflammation. Redox Biology, [PMID:41353801] [10.1016/j.redox.2025.103961] |
| 20. Ruman Chen, Jiqing He, Na An, Mingzhi Xu, Liheng Wang, Yafei Bai. (2026) MiR-181c-5p-SIRT1 axis-driven Pink1/Parkin-mediated mitophagy prevents ferroptosis and vascular calcification in chronic kidney disease. EXPERIMENTAL CELL RESEARCH, [PMID:41512994] [10.1016/j.yexcr.2025.114875] |
| 21. Chengsi Li, Jing Li, Chengyingjie Yang, Zhenghao Zhu, Yachen Zhang, Yin Xiang. (2026) Vericiguat improves CKD-related vascular calcification through the NO/cGMP/PKG pathway. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:41723893] [10.1016/j.intimp.2026.116413] |
| 22. Guangxiao Zhang, Yawen Sun, Ling He, Bowen Zhao, Hongchao Jiao, Jingpeng Zhao, Xiaojuan Wang, Min Liu, Kelin Li, Hai Lin, Haifang Li. (2026) In ovo injection of vitamin D3 improves intestinal development of chicks via activating vitamin D receptor. POULTRY SCIENCE, 105 (5): (106672). [PMID:41723960] [10.1016/j.psj.2026.106672] |
| 23. Zi Lin Li, Gang Wang, Yilin Ding, Qiyuan Dai, Huitong Luo, Zhifeng Shi, Xinrong Xu, Xiaodong Cao. (2026) High performance injectable PLLA/BG composite microspheres in aging skin regeneration. Biomaterials Advances, [PMID:] [10.1016/j.bioadv.2026.214823] |
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