Information
Calcium D-Panthotenate (D-Pantothenic Acid Calcium), also called vitamin B5 Calcium, is a water-soluble vitamin and an essential nutrient for many animals.
In vitro
Pantothenic\xa0acid\xa0increases mainly the content of free\xa0glutathione, with little effect on protein-boundglutathione in human lymphoblastoic (Jurkat) cells.\xa0Pantothenic\xa0acid also increases\xa0cell\xa0respiration with pyruvate as the exogenous substrate. Pantothenic\xa0acid belongs to vitamin B group and is the building stone of coenzyme A. Pantothenic\xa0acid can be therefore infer that its beneficial effect in various kinds of cell damage by ROS is related to the increased content or stimulated biosynthesis of this coenzyme. Pantothenic\xa0acid increases the glutathione content by more than 50% and increases the GSH/GSSG ratio by approximately the same factor. Pantothenic\xa0acid\xa0and N-acetylcysteine alleviates the\xa0ultraviolet-induced decrease of glutathione content, diminished lipid peroxidation, and partly protects the\xa0cells\xa0against\xa0apoptosisproduced by\xa0ultraviolet\xa0irradiation.
In vivo
Pantothenic acid-treated rats exhibited higher basal levels of corticosterone and progesterone than control rats in Adrenal cells. The response of ACTH and/or PRL on corticosterone and progesterone release is higher in the pantothenic acid-treated rats than in the control rats. Pantothenic acid supplementation stimulates the ability of adrenal cells in male rats to secrete corticosterone and progesterone. Pantothenic acid supplementation induces adrenalhyperresponsiveness to ACTH stimulation, and PRL further stimulated adrenal sensitivity to ACTH. Pantothenic acid prior to valproic acid (VPA) significantly protects against VPA-induced neural tube defects (NTDs) in CD-1mice. Pantothenic acid prevents VPA-induced alterations in NF-kappaB, Pim-1, and c-Myb in CD-1 mice.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:
| Isómeros SMILES | CC(C)(CO)[C@H](C(=O)NCCC(=O)[O-])O.CC(C)(CO)[C@H](C(=O)NCCC(=O)[O-])O.[Ca+2] |
|---|---|
| RTECS | RU4375000 |
| Peso molecular | 476.54 |
| Beilstein | 4(3)1286 |
| Reaxy-Rn | 4049460 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4049460&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Rotación específica [α] | 27 ° (C=5, H2O) |
|---|---|
| Punto de fusión (°C) | 195-196°C |
| 1. Weng Chunyue, Mi Zheyan, Li Meijing, Qin Haibin, Hu Zhongce, Liu Zhiqiang, Zheng Yuguo, Wang Yuanshan. (2022) Improvement of S-adenosyl-L-methionine production in Saccharomyces cerevisiae by atmospheric and room temperature plasma-ultraviolet compound mutagenesis and droplet microfluidic adaptive evolution. 3 Biotech, 12 (9): (1-15). [PMID:35975026] [10.1007/s13205-022-03297-x] |
| 2. Naymul Karim, Mohammad Rezaul Islam Shishir, Tao Bao, Wei Chen. (2021) Effect of cold plasma pretreated hot-air drying on the physicochemical characteristics, nutritional values and antioxidant activity of shiitake mushroom. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 101 (15): (6271-6280). [PMID:33949697] [10.1002/jsfa.11296] |
| 3. Naiyi Yin, Zeliang Han, Huili Du, Pengfei Wang, Yunpeng Li, Xiaochen Chen, Guoxin Sun, Yanshan Cui, Zhengyi Hu. (2020) Effect of dietary vitamins in oral bioaccessibility of lead in contaminated soils based on the physiologically based extraction test. SCIENCE OF THE TOTAL ENVIRONMENT, [PMID:32791414] [10.1016/j.scitotenv.2020.141299] |
| 4. Zhuo Wang, Weixiao Nan, Huazhe Si, Shiyong Wang, Haihua Zhang, Guangyu Li. (2020) Pantothenic acid promotes dermal papilla cell proliferation in hair follicles of American minks via inhibitor of DNA Binding 3/Notch signaling pathway. LIFE SCIENCES, [PMID:32304761] [10.1016/j.lfs.2020.117667] |
| 5. Kangyuan Qu, Siyuan Xiong, Caiqian Huang, Xiaoxia Jiang, Lixia Tian, Shiwei Xie. (2024) Dietary supplementation of ornithine improved the growth, immune response and acute NH3 stress tolerance of Pacific white shrimp, Penaeus vannamei. Aquaculture Reports, [PMID:] [10.1016/j.aqrep.2024.102095] |
| 6. Haolin Zhang, Jingjing Zhang, Hui Cao, Petra Högger, Randolph Arroo, Mohamed A. Farag, Avi Shpigelman, Jianbo Xiao, Chunlin Li. (2025) Amination of Flavonoids Possessing a Pyrogallol Group in Cell Culture Medium at 37°C. Food Frontiers, 6 (2): (1058-1078). [PMID:] [10.1002/fft2.70002] |
