Calpain Inhibitor XII, CAS No.181769-57-3

CAS: 181769-57-3 Cat. No.: C341237 Peso molecular: 482.57
Disponible para pedir
GRADE & PURITY ≥90%
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
1mg
C341237-1mg
2
149,90US$
5mg
C341237-5mg
1
519,90US$
10mg
C341237-10mg
1

706,90US$

879,90US$
Guardar 173,00 US$ (19.66%)
25mg
C341237-25mg
1

1.324,90US$

1.869,90US$
Guardar 545,00 US$ (29.15%)
50mg
C341237-50mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.

1.971,90US$

3.179,90US$
Guardar 1.208,00 US$ (37.99%)
100mg
C341237-100mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.

2.942,90US$

5.399,90US$
Guardar 2.457,00 US$ (45.50%)
Enter a quantity for the sizes you want to add.
🧪

Why this grade

≥90% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Calpain Inhibitor XII is a cell-permeable, potent, selective, reversible, and active-site-directed inhibitor of calpain-1 (K|i|= 19 nM). Calpain Inhibitor XII has been shown to inhibit calpain-2 (K|i|= 120 nM) and human cathepsin B (K|i|= 750 nM) only at higher concentrations. Calpain Inhibitor XII has been reported to induce neutrophile polarization and chemokinesis.

Specifications

Product Name
Calpain Inhibitor XII, CAS No.181769-57-3
Sinónimos
(Rac)-Calpain Inhibitor XII | [3-methyl-1-[[[1-[oxo[(2-pyridinylmethyl)amino]acetyl]butyl]amino]carbonyl]butyl]-carbamic acid, phenylmethyl ester
Especificaciones y pureza
≥90%
Secuencia
Z-Leu-Nva-CONH-CH2-2-Pyridyl
Tipo de acción
INHIBITOR
CAS
181769-57-3
Tipo de molécula
Small molecule
Almacenamiento y envío
Condiciones de almacenamiento de almacenamiento
Store at -20°C,Argon charged
Enviado en
Ice chest + Ice pads

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic acids and derivatives
ClaseCarboxylic acids and derivatives
SubclassAmino acids, peptides, and analogues
Intermediate Tree Nodes Amino acids and derivatives - Alpha amino acids and derivatives
Direct ParentLeucine and derivatives
Alternative Parents Alpha amino acid amides  Benzyloxycarbonyls  Pyridines and derivatives  N-acyl amines  Heteroaromatic compounds  Carbamate esters  Secondary carboxylic acid amides  Ketones  Azacyclic compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents Leucine or derivatives - Alpha-amino acid amide - Benzyloxycarbonyl - Monocyclic benzene moiety - Fatty amide - N-acyl-amine - Pyridine - Fatty acyl - Benzenoid - Heteroaromatic compound - Carbamic acid ester - Secondary carboxylic acid amide - Ketone - Carboxamide group - Azacycle - Organoheterocyclic compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organic oxygen compound - Aromatic heteromonocyclic compound
DescripciónThis compound belongs to the class of organic compounds known as leucine and derivatives. These are compounds containing leucine or a derivative thereof resulting from reaction of leucine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
External Descriptors Not available
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
CTSB Tchem Cathepsin B (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CAPN2 Tchem Calpain-2 catalytic subunit (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CAPN1 Tchem Calpain-1 catalytic subunit (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CTSB Tchem Cathepsin B (3822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CAPN2 Tchem Calpain 2 (185 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Objetivos asociados (no humanos)
CAPN1 Calpain 1 (219 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot NumberCertificate TypeFechaArticulo
F2512239Certificate of AnalysisNov 06, 2024 C341237
F2512246Certificate of AnalysisNov 06, 2024 C341237
F2512260Certificate of AnalysisNov 06, 2024 C341237
F2512262Certificate of AnalysisNov 06, 2024 C341237
F2512263Certificate of AnalysisNov 06, 2024 C341237
F2512264Certificate of AnalysisNov 06, 2024 C341237
F2512265Certificate of AnalysisNov 06, 2024 C341237
F2512266Certificate of AnalysisNov 06, 2024 C341237
F2512288Certificate of AnalysisNov 06, 2024 C341237
F2512289Certificate of AnalysisNov 06, 2024 C341237
Calculadoras de soluciones
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