Carbidopa - Moligand™, 10mM in DMSO , Inhibitor of L-Aromatic amino-acid decarboxylase , CAS No.28860-95-9, Inhibitor of L-Aromatic amino-acid decarboxylase

CAS: 28860-95-9 Cat. No.: C408039 Peso molecular: 226.23 Número EC: 249-271-9

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

(αS)​-α-​hydrazinyl-​3,​4-​dihydroxy-​α-​methyl-​benzenepropanoic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Carbidopa Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM.
In vitro

In vivo

Cell Data

cell lines：Breast cancer cell lines including SW620 colon, A2780 ovarian, HCC1937, Hs578T, MDA-MB-231, MDA-MB-436, and T47D

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

(αS)​-α-​hydrazinyl-​3, ​4-​dihydroxy-​α-​methyl-​benzenepropanoic acid

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of L-Aromatic amino-acid decarboxylase

Nombres e identificadores

• Isómeros SMILES: C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)NN
• WGK Alemania: 3
• CAS alternativo: 38821-49-7
• Peso molecular: 226.23
• Reaxy-Rn: 657532
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=657532&ln=

Objetivos asociados (humanos)

DDC Tclin Aromatic-L-amino-acid decarboxylase (0 Activities)

Discover Target: DDC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro

Referencias

1. Jin Yuan Zhang, Ying Zhang, Yu Zou, Ze Li Bo Xu, Bo Zhang, Wang Ren.  (2023)  Physicochemically modulated fluorescence-scattering ratiometric sensor for selective and visual detection of levodopa.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:38091648] [10.1016/j.saa.2023.123746]

2. Da-Wei Zhou, Meng Yin, Yun Shen, Xiao-Xue Wang, Chen-Yu Wang, Ke-Zheng Chen, Qi Fang, Sheng-Lin Qiao.  (2024)  LDHzyme-assisted high-performance on-site tracking of levodopa pharmacokinetics for Parkinson's disease management.  BIOSENSORS & BIOELECTRONICS,      [PMID:39536419] [10.1016/j.bios.2024.116926]

3. Shanying Han, Tianyu Du, Hui Jiang, Xuemei Wang.  (2016)  Synergistic effect of pyrroloquinoline quinone and graphene nano-interface for facile fabrication of sensitive NADH biosensor.  BIOSENSORS & BIOELECTRONICS,      [PMID:27156055] [10.1016/j.bios.2016.04.092]