GRADE & PURITY 10mM in DMSO

Synonyms

1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo-, ethyl ester

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Carbimazole is an imidazole antithyroid agent.
In vitro

Carbimazole is an effective thyroid hormone inhibitor under a class of drugs known as pro-drugs. It is considered a pro-drug because it converts to methimazole after being absorbed by the body, generating an antithyroid action that works against hyperthyroidism (excessive production of thyroid hormones) and thyrotoxicosis (inflammation of the thyroid gland). Methimazole prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4 (thyroxine).

In vivo

Cell Data

cell lines：Human breast cancer cells MDA-MB-231

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

1H-Imidazole-1-carboxylic acid, 2, 3-dihydro-3-methyl-2-thioxo-, ethyl ester

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Carbimazole is an imidazole antithyroid agent.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Mecanismo de acción

Thyroid peroxidase inhibitor

Propiedades del producto

• ALogP: 0.7

Nombres e identificadores

• Isómeros SMILES: CCOC(=O)N1C=CN(C1=S)C
• WGK Alemania: 3
• Peso molecular: 186.23
• Reaxy-Rn: 144339
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=144339&ln=

Propiedades químicas y físicas

• Punto de fusión (°C): 124 °C

Referencias

1. Nian Liu, Shuchao Zhang, Yiliang Liu, Xing Lu, Xiaozhen He.  (2025)  Potential Mechanisms Underlying Carbimazole-Induced Cardiotoxicity and Hepatotoxicity in Zebrafish.  JOURNAL OF APPLIED TOXICOLOGY,      [PMID:40784728] [10.1002/jat.4889]