Cariprazine - Moligand™, ≥98% , Agonist of D 2 receptor;Agonist of D 3 receptor, CAS No.839712-12-8, Agonist of D 2 receptor;Agonist of D 3 receptor

CAS: 839712-12-8 Cat. No.: C126186 Peso molecular: 427.41 Número EC: 111-198-4

GRADE & PURITY Moligand™, ≥98%

Synonyms

AS-74411 | AKOS027250814 | 5-chloro-2-mercapto-benzoxazol | DB06016 | FT-0605496 | GLXC-90442 | Q2938837 | BDBM50443094 | DTXSID60220767 | AC-35342 | RGH-188; RGH188; RGH 188; MP-214; MP 214; MP214 | US9550741, RGH-188 | EN300-7406880 | MFCD19443701 | BDB

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Cariprazine(RGH188) is a novel antipsychotic drug candidate that exhibits high selectivity and affinity to dopamine D3(Ki=0.09 nM) and D2 (Ki=0.5 nM) receptors and moderate affinity to serotonin 5-HT(1A) receptors.

Specifications

Sinónimos

AS-74411 | AKOS027250814 | 5-chloro-2-mercapto-benzoxazol | DB06016 | FT-0605496 | GLXC-90442 | Q2938837 | BDBM50443094 | DTXSID60220767 | AC-35342 | RGH-188; RGH188; RGH 188; MP-214; MP 214; MP214 | US9550741, RGH-188 | EN300-7406880 | MFCD19443701 | BDB

Especificaciones y pureza

Moligand™, ≥98%

Mecanismos bioquímicos y fisiológicos

Description:
IC50 Value: 0.5 and 0.09 nM (Ki for D2 and D3 receptor respectively); 2.6 and 180 nM(Ki for 5-HT1A and 5-HT2A receptor respectively) [1]
Cariprazine is a novel antipsychotic drug candidate that exhibits high selecti

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

AGONIST

Mecanismo de acción

Agonist of D 2 receptor;Agonist of D 3 receptor

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: CN(C)C(=O)NC1CCC(CC1)CCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl
• IUPAC Name: 3-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea
• InChIKey: KPWSJANDNDDRMB-UHFFFAOYSA-N
• INCHI: 1S/C21H32Cl2N4O/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23/h3-5,16-17H,6-15H2,1-2H3,(H,24,28)
• Isómeros SMILES: CN(C)C(=O)NC1CCC(CC1)CCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl
• Peso molecular: 427.41
• Reaxy-Rn: 18765165
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18765165&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Diazinanes
      • Subclass Piperazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Diazinanes
• Subclass: Piperazines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpiperazines
• Alternative Parents: N-arylpiperazines Dichlorobenzenes Dialkylarylamines Aniline and substituted anilines N-alkylpiperazines Aryl chlorides Ureas Trialkylamines Azacyclic compounds Organochlorides Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Phenylpiperazine - N-arylpiperazine - 1,2-dichlorobenzene - Tertiary aliphatic/aromatic amine - Dialkylarylamine - Aniline or substituted anilines - N-alkylpiperazine - Chlorobenzene - Halobenzene - Aryl chloride - Benzenoid - Aryl halide - Monocyclic benzene moiety - Urea - Tertiary aliphatic amine - Tertiary amine - Azacycle - Organic oxide - Organochloride - Organohalogen compound - Organonitrogen compound - Amine - Organooxygen compound - Carbonyl group - Organic nitrogen compound - Organic oxygen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as phenylpiperazines. These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

DRD2 Tclin D(2) dopamine receptor (24 Activities)

Discover Target: DRD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD3 Tclin D(3) dopamine receptor (10 Activities)

Discover Target: DRD3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: 25°C: DMSO
• Peso molecular: 427.400 g/mol
• XLogP3: 4.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 426.195 Da
• Monoisotopic Mass: 426.195 Da
• Topological Polar Surface Area: 38.800 Ų
• Heavy Atom Count: 28
• Formal Charge: 0
• Complexity: 491.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Haowei Liu, Qiuming Huang, Yunqi Fan, Bo Li, Xuemei Liu, Changhua Hu.  (2023)  Dissecting the novel abilities of aripiprazole: The generation of anti-colorectal cancer effects by targeting Gαq via HTR2B.  Acta Pharmaceutica Sinica B,      [PMID:37655314] [10.1016/j.apsb.2023.05.015]

2. Fan Wang, Chao-bao Liu, Yi Wang, Xi-xi Wang, Yuan-yao Yang, Chang-you Jiang, Qiu-min Le, Xing Liu, Lan Ma, Fei-fei Wang.  (2024)  Morphine- and foot shock-responsive neuronal ensembles in the VTA possess different connectivity and biased GPCR signaling pathway.  Theranostics,      [PMID:38250036] [10.7150/thno.90792]

3. Li Hai-bo, Liu Yong-hui, Liu Hai, Li Yuan, Le Qiu-min, Wang Fei-fei, Ma Lan, Liu Xing.  (2026)  G protein-dependent dopamine D2 receptor signaling mediates cocaine-primed reinstatement.  ACTA PHARMACOLOGICA SINICA,      [PMID:41535707] [10.1038/s41401-025-01700-w]