Caroverine hydrochloride - ≥96% , CAS No.55750-05-5

CAS: 55750-05-5 Cat. No.: C650822 Peso molecular: 401.93 PubChem CID: 3043582

GRADE & PURITY ≥96%

Synonyms

Caroverine HCl | 1-Diethylaminoethyl-3-(p-methoxybenzyl)-2-quinoxaone hydrochloride | NCGC00261945-01 | MLS004712063 | P 201-1 | DTXSID20971127 | Caroverine (hydrochloride) | Q27285818 | Tox21_501260 | Caroverine hydrochloride | SMR001456556 | UNII-OSH993

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Descripción general

Caroverine (Tinnex) hydrochloride is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor . Caroverine hydrochloride is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action. Caroverine hydrochloride can be used for the research of inner ear tinnitus

In Vitro

Caroverine (1 μM; pretreated for 10 min) inhibits the pressor response to KCl (80 mM) and noradrenaline (1 μM) in the rat hindquarter preparation. Caroverine markedly suppresses the contraction caused by KCl (40 mM) in the rat isolated aorta. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Caroverine (1.44 mg/rat; s.c; 1.0 mL/h for 72 h) attenuates impulse noise-induced hearing loss in the rat. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Sprague-Dawley rats of either sex (250-300 g) received impulse noise exposureDosage: 1.44 mg/rat Administration: 20 mg/mL; s.c. 1.0 mL/h for 72 h Result: Significantly protected the cochlea against impulse noise trauma.

Form:Solid

IC50& Target:NMDA, AMPA

Specifications

Sinónimos

Caroverine HCl | 1-Diethylaminoethyl-3-(p-methoxybenzyl)-2-quinoxaone hydrochloride | NCGC00261945-01 | MLS004712063 | P 201-1 | DTXSID20971127 | Caroverine (hydrochloride) | Q27285818 | Tox21_501260 | Caroverine hydrochloride | SMR001456556 | UNII-OSH993

Especificaciones y pureza

≥96%

Mecanismos bioquímicos y fisiológicos

Caroverine (Tinnex) hydrochloride is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor . Caroverine hydrochloride is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action. Caroverine hydrochlori

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C, Desiccated

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

ANTAGONIST

Pureza

≥96%

Nombres e identificadores

• Sonrisas canónicas: CCN(CC)CCN1C2=CC=CC=C2N=C(C1=O)CC3=CC=C(C=C3)OC.Cl
• IUPAC Name: 1-[2-(diethylamino)ethyl]-3-[(4-methoxyphenyl)methyl]quinoxalin-2-one;hydrochloride
• InChIKey: JRNWTJUIMRLKBV-UHFFFAOYSA-N
• INCHI: 1S/C22H27N3O2.ClH/c1-4-24(5-2)14-15-25-21-9-7-6-8-19(21)23-20(22(25)26)16-17-10-12-18(27-3)13-11-17;/h6-13H,4-5,14-16H2,1-3H3;1H
• Isómeros SMILES: CCN(CC)CCN1C2=CC=CC=C2N=C(C1=O)CC3=CC=C(C=C3)OC.Cl
• WGK Alemania: 3
• PubChem CID: 3043582
• Peso molecular: 401.93

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Diazanaphthalenes
      • Subclass Benzodiazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Diazanaphthalenes
• Subclass: Benzodiazines
• Intermediate Tree Nodes: Not available
• Direct Parent: Quinoxalines
• Alternative Parents: Phenoxy compounds Methoxybenzenes Anisoles Alkyl aryl ethers Pyrazines Heteroaromatic compounds Trialkylamines Lactams Azacyclic compounds Organic oxides Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Quinoxaline - Phenoxy compound - Anisole - Phenol ether - Methoxybenzene - Alkyl aryl ether - Monocyclic benzene moiety - Pyrazine - Benzenoid - Heteroaromatic compound - Lactam - Tertiary amine - Tertiary aliphatic amine - Azacycle - Ether - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Organic oxide - Hydrochloride - Amine - Organic oxygen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as quinoxalines. These are compounds containing a quinoxaline moiety, a bicyclic heterocycle made up of a benzene ring fused to a pyrazine ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: DMSO : 100 mg/mL (248.80 mM; Need ultrasonic) H2O : 20 mg/mL (49.76 mM; Need ultrasonic)
• Peso molecular: 401.900 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 401.187 Da
• Monoisotopic Mass: 401.187 Da
• Topological Polar Surface Area: 45.100 Ų
• Heavy Atom Count: 28
• Formal Charge: 0
• Complexity: 510.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

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