Caspofungin (MK-0991) Acetate - 10mM in Water , 1,3-beta-glucan synthase inhibitor, CAS No.179463-17-3, 1,3-beta-glucan synthase inhibitor

CAS: 179463-17-3 Cat. No.: C408660 Peso molecular: 1213.42 Número EC: 605-859-0 PubChem CID: 6850808

GRADE & PURITY 10mM in Water

Synonyms

L-743872 | Pneumocandin B0, 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-, acetate (1:2)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Caspofungin (MK-0991) Acetate Caspofungin Acetate (MK-0991, L-743872) is an lipopeptide antifungal β-1,3-glucan synthase inhibitor.
In vitro

Caspofungin acetate is the first in a new class of antifungals that inhibits the synthesis of beta (1, 3)-d-glucan, an essential component of the cell wall of filamentous fungi. Prior studies have shown in vitro activity of caspofungin acetate using the reference methods, broth microdilution or macrodilution, for antifungal susceptibility testing of Candida species established by the National Committee for Clinical Laboratory Standards 1997 guidelines against a variety of Candida species including Candida krusei. Although caspofungin acetate is only Food and Drug Administration-approved for the treatment of aspergillosis, there is information showing that many Candida species are susceptible. The minimal inhibitory concentration for 90% inhibition of Candida species by caspofungin acetate are as follows:C. albicans 0.5 μg/mL (range, 0.25-0.5), C. glabrata 1.0 μg/mL (range, 0.25-2.0), C. tropicalis 1.0 μg/mL (range, 0.25-1.0), C. parapsilosis 0.5 μg/mL (range, 0.25-1.0), and C. krusei 2.0 μg/mL (range, 0.5-2.0)

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Sinónimos

L-743872 | Pneumocandin B0, 1-[(4R, 5S)-5-[(2-aminoethyl)amino]-N2-[(10R, 12S)-10, 12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-, acetate (1:2)

Especificaciones y pureza

10mM in Water

Mecanismos bioquímicos y fisiológicos

Caspofungin Acetate (MK-0991, L-743872) is an lipopeptide antifungal β-1, 3-glucan synthase inhibitor.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Mecanismo de acción

1, 3-beta-glucan synthase inhibitor

Nombres e identificadores

• Isómeros SMILES: CCC(C)CC(C)CCCCCCCCC(=O)N[C@H]1C[C@H]([C@H](NC(=O)[C@@H]2[C@H](CCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@@H](NC1=O)[C@@H](C)O)O)[C@@H]([C@H](C4=CC=C(C=C4)O)O)O)[C@@H](CCN)O)O)NCCN)O.CC(=O)O.CC(=O)O
• WGK Alemania: 3
• RTECS: TP8046500
• PubChem CID: 6850808
• Peso molecular: 1213.42

Referencias

1. Longfei Yang, Xiaonan Wang, Zhiming Ma, Yujie Sui, Xin Liu.  (2024)  Fangchinoline inhibits growth and biofilm of Candida albicans by inducing ROS overproduction.  JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,  28  (9): (e18354).  [PMID:38686557] [10.1111/jcmm.18354]