10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC 50 value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion.
In Vitro
CAY10650 (12 nM; 30 min; neutrophils) inhibits the expression of the phosphorylated cPLA2-α (p-cPLA2-α) in cells. CAY10650 (12 nM; 2 h; neutrophils) inhibits PGE2 release in neutrophils. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: Neutrophils Concentration: 12 nM Incubation Time: 30 minutes Result: Inhibited cPLA2-α and inhibited the expression of the p-cPLA2-α. Western Blot AnalysisCell Line: Neutrophils Concentration: 12 nM Incubation Time: 2 hours Result: Inhibited the PGE 2 secretion and inhibited PGE 2 realease.
In Vivo
CAY10650 (50 μg/5 μL; Inject with topical eye-drop; Chinese hamsters) relieves acanthamoeba keratitis in vivo. . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Chinese hamsters with infected with parasite-laden contact lenses Dosage: 50 μg/5 μL Administration: Inject with topical eye-drop under the contact lens; three times a day for 6 days and topically on days 7 to 20 postinfection Result: Reduced the severity of the keratitis and hasten the onset of resolution. Had little mild inflammation and very few PMNs infiltration in the corneal stroma.
| Isómeros SMILES | CC(C)C(=O)C1=CN(C2=C1C=C(C=C2)C(=O)O)CC(=O)COC3=CC=C(C=C3)OC4=CC=CC=C4 |
|---|---|
| PubChem CID | 45102612 |
| Términos de entrada MeSH | 3-isobutanoyl-1-(2-oxo-3-(4-phenoxyphenoxy)propyl)indole-5-carboxylic acid;3-isobutanoyl-1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid;3-isobutanoyl-OPICA |
| Peso molecular | 471.50 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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