CeMMEC1 - 10mM in DMSO , CAS No.440662-09-9

CAS: 440662-09-9 Cat. No.: C655538 Peso molecular: 336.34

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

CeMMEC1 is an inhibitor of BRD4 , and also has high affinity for TAF1 , with an IC 50 of 0.9 μM for TAF1, and a K d of 1.8 μM for TAF1 (2).

In Vitro

CeMMEC1 is an inhibitor of BRD4, and also has high affinity for TAF1, with an IC 50 of 0.9 μM for TAF1, and a K d of 1.8 μM for TAF1 (2) and slso shows high affinity for the bromodomains of CREBBP, EP300, BRD9. CeMMEC1 (1, 10, 20 μM) decreases the number of THP1 cells in S phase in a dose manner. CeMMEC1 also induces apoptosis. CeMMEC1 in combination with (S)-JQ1 displays potently impaired cell viability than treatment alone. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Kd: 1.8 μM (TAF1 (2)), IC50: 0.9 μM (TAF1)

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

CeMMEC1 is an inhibitor of BRD4 , and also has high affinity for TAF1 , with an IC 50 of 0.9 μM for TAF1, and a K d of 1.8 μM for TAF1 (2).

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Nombres e identificadores

• Isómeros SMILES: CN1C=C(C2=CC=CC=C2C1=O)C(=O)NC3=CC4=C(C=C3)OCCO4
• Peso molecular: 336.34
• Reaxy-Rn: 31684664
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=31684664&ln=